Maintenance of Differential Expression of Transforming Growth Factor-β (TGF-β) Isoforms by Normal, Ulcerative Colitis (UC) & Crohn's Disease (CD) Intestinal Myofibroblasts (IMFs) despite Prolonged Culture and Passage

2000 ◽  
Vol 98 (s42) ◽  
pp. 16P-16P
Author(s):  
BC McKaig ◽  
CJ Hawkey ◽  
YR Mahida
Keyword(s):  
Ulcerative Colitis ◽  
Crohn’S Disease ◽  
Growth Factor ◽  
Crohn's Disease ◽  
Differential Expression ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Prolonged Culture

scholarly journals Enteral Nutrition Supplemented with Transforming Growth Factor-β, Colostrum, Probiotics, and Other Nutritional Compounds in the Treatment of Patients with Inflammatory Bowel Disease

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1048
Author(s):  
John K. Triantafillidis ◽  
Maria Tzouvala ◽  
Eleni Triantafyllidi
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Bowel Disease ◽  
Crohn’S Disease ◽  
Growth Factor ◽  
Enteral Nutrition ◽  
Bowel Disease ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Active Ulcerative Colitis ◽  
Inflammatory Bowel

Enteral nutrition seems to play a significant role in the treatment of both adults and children with active Crohn’s disease, and to a lesser degree in the treatment of patients with active ulcerative colitis. The inclusion of some special factors in the enteral nutrition formulas might increase the rate of the efficacy. Actually, enteral nutrition enriched in Transforming Growth Factor-β reduced the activity index and maintained remission in patients with Crohn’s disease. In addition, a number of experimental animal studies have shown that colostrum exerts a significantly positive result. Probiotics of a special type and a certain dosage could also reduce the inflammatory process in patients with active ulcerative colitis. Therefore, the addition of these factors in an enteral nutrition formula might increase its effectiveness. Although the use of these formulas is not supported by large clinical trials, it could be argued that their administration in selected cases as an exclusive diet or in combination with the drugs used in patients with inflammatory bowel disease could benefit the patient. In this review, the authors provide an update on the role of enteral nutrition, supplemented with Transforming Growth Factor-β, colostrum, and probiotics in patients with inflammatory bowel disease.

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