The Role of Transforming Growth Factor-β in the Regulation of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases by Pancreatic Stellate Cells: Implications for Chronic Pancreatitis

2002 ◽  
Vol 103 (s47) ◽  
pp. 40P-41P ◽  
Author(s):  
FW Shek ◽  
Walker Fmj ◽  
Pender Slf ◽  
V. Chance ◽  
EJ Williams ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Growth Factor ◽  
Matrix Metalloproteinases ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β ◽  
Pancreatic Stellate Cells ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Tissue Inhibitors

scholarly journals New aspects of formation and progression of pancreatic fibrosis in pancreatitis

2019 ◽  
Vol 43 (2) ◽  
pp. 20-24
Author(s):  
V. A. Akhmedov ◽  
O. V. Gaus
Keyword(s):  
Extracellular Matrix ◽  
Chronic Pancreatitis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β ◽  
Pancreatic Fibrosis ◽  
Pancreatic Stellate Cells ◽  
Main Components ◽  
Acute And Chronic Pancreatitis

Fibrosis formation is a dynamic process during which the formation of an extracellular matrix takes place in interstitial spaces and areas where the main components of exocrine pancreatic function (acinar cells) are damaged. According to studies, the biggest role in the formation of pancreatic fibrosis upon chronic pancreatitis is played by various types of effector cells, such as fibroblasts, myofibroblasts and fibrocytes, while fibroblasts and myofibroblasts are the key fibrosis cells responsible for the secretion of extracellular matrix. Activated pancreatic stellate cells become main components of fibrosis formation in patients with chronic pancreatitis, synthesizing transforming growth factor-β, fibroblast growth factor, which leads to enhanced synthesis of extracellular matrix. The presented review highlights molecular mechanisms (Rho-kinase, mitogen-activating protein kinase, transforming growth factor-β, associated with the protein encoded by SMAD in humans, phosphatidylinositol-3 kinase), which play an important role in the activation of pancreatic stellate cells and launching the phenomenon of pancreatic fibrogenesis. The presented data opens up prospects for the development of diagnostic areas with the search for new markers for the diagnosis of acute and chronic pancreatitis along with development of new therapeutic options for the pathogenetic therapy of patients with acute and chronic pancreatitis based on the results obtained.

Transforming growth factor-β induces nerve growth factor expression in pancreatic stellate cells by activation of the ALK-5 pathway

2009 ◽  
Vol 27 (5) ◽  
pp. 289-299 ◽  
Author(s):  
Stephan L. Haas ◽  
Stephan L. Haas ◽  
Brit Fitzner ◽  
Stephan L. Haas ◽  
Brit Fitzner ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β ◽  
Pancreatic Stellate Cells ◽  
Nerve Growth Factor Expression ◽  
Factor Expression ◽  
Growth Factor Expression ◽  
Alk 5

Role of Fibroblast Growth Factor-2 in the Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Human Intestinal Myofibroblasts

Digestion ◽  
2004 ◽  
Vol 69 (1) ◽  
pp. 34-44 ◽  
Author(s):  
Hirofumi Yasui ◽  
Akira Andoh ◽  
Shigeki Bamba ◽  
Osamu Inatomi ◽  
Hideaki Ishida ◽  
...  
Keyword(s):  
Growth Factor ◽  
Matrix Metalloproteinases ◽  
Fibroblast Growth Factor ◽  
Tissue Inhibitors Of Metalloproteinases ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Tissue Inhibitors

scholarly journals Expression of Transforming Growth Factor-β1 by Pancreatic Stellate Cells and Its Implications for Matrix Secretion and Turnover in Chronic Pancreatitis

2002 ◽  
Vol 160 (5) ◽  
pp. 1787-1798 ◽  
Author(s):  
Fanny Wai-Tsing Shek ◽  
Robert Christopher Benyon ◽  
Fiona Mairi Walker ◽  
Peter Raymond McCrudden ◽  
Sylvia Lin Foon Pender ◽  
...  
Keyword(s):  
Chronic Pancreatitis ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Stellate Cells ◽  
Transforming Growth Factor Β1 ◽  
Pancreatic Stellate Cells
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