Is T-cadherin (CDH13, H-cadherin) expression related to lung metastasis of osteosarcoma?

2000 ◽  
Vol 37 (2) ◽  
pp. 193-194 ◽  
Author(s):  
T Takeuchi ◽  
A Misaki ◽  
H Sonobe ◽  
S-B Liang ◽  
Y Ohtsuki
Keyword(s):  
Lung Metastasis

1011: Suppression of Renal Cell Carcinoma Lung Metastasis by Adeno-Associated Virus (AAV) Mediated Gene Transfer of a Soluble Receptor of VEGF

2004 ◽  
Vol 171 (4S) ◽  
pp. 267-267
Author(s):  
Ichiro Yoshimura ◽  
Yasunori Mizuguchi ◽  
Akira Miyajima ◽  
Tomohiko Asano ◽  
Hiroaki Mizukami ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Gene Transfer ◽  
Cell Carcinoma ◽  
Lung Metastasis ◽  
Renal Cell ◽  
Soluble Receptor ◽  
Adeno Associated Virus

Deoxyelephantopin suppresses lung metastasis of B16 melanoma in mice

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
W Chao ◽  
Y Cheng ◽  
S Lee ◽  
L Shyur
Keyword(s):  
Lung Metastasis ◽  
B16 Melanoma

Nerve Growth Factor overexpression in Clara cells suppresses metastasis and tumor growth in a mouse model of experimental lung metastasis

Pneumologie ◽  
2012 ◽  
Vol 66 (06) ◽  
Author(s):  
K Seidler ◽  
A Sydykov ◽  
S Müller-Brüsselbach ◽  
R Müller ◽  
N Weißmann ◽  
...  
Keyword(s):  
Nerve Growth Factor ◽  
Growth Factor ◽  
Mouse Model ◽  
Tumor Growth ◽  
Lung Metastasis ◽  
Clara Cells ◽  
Nerve Growth

Author response for "Role of Platelet C‐Type Lectin‐Like Receptor 2 in Promoting Lung Metastasis in Osteosarcoma"

2020 ◽  
Author(s):  
Jiro Ichikawa ◽  
Takashi Ando ◽  
Tomonori Kawasaki ◽  
Tomoyuki Sasaki ◽  
Toshiaki Shirai ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Author Response

Defective lung CD8+ T cells lacking NFATc2 induced lung metastasis in NFATc2 deficient mice in a bronchoalveolar adenocarcinoma murine model

Pneumologie ◽  
2007 ◽  
Vol 61 (01) ◽  
Author(s):  
JH Maxeiner ◽  
R Karwot ◽  
K Sauer ◽  
P Scholtes ◽  
R Wiewrodt ◽  
...  
Keyword(s):  
T Cells ◽  
Lung Metastasis ◽  
Cd8 T Cells ◽  
Murine Model ◽  
Deficient Mice

Cytogenetic findings in a primary malignant fibrous histiocytoma of bone and the lung metastasis

Pathology ◽  
1990 ◽  
Vol 22 (1) ◽  
pp. 16-19 ◽  
Author(s):  
Julia A. Bridge ◽  
Warren G. Sanger ◽  
James R. Neff ◽  
Michelle M. Hess
Keyword(s):  
Lung Metastasis ◽  
Malignant Fibrous Histiocytoma ◽  
Fibrous Histiocytoma

Peptides of Tetraspanin Oncoprotein CD151 Trigger Active Immunity Against Primary Tumor and Experimental Lung Metastasis

2019 ◽  
Author(s):  
Wanzun Lin ◽  
Jun Liu ◽  
Juhui Chen ◽  
Jiancheng Li ◽  
Sufang Qiu ◽  
...  
Keyword(s):  
Lung Metastasis ◽  
Primary Tumor ◽  
Active Immunity

CDK12 Promotes Breast Cancer Progression and Maintains Stemness by Activating c-myc/β -catenin Signaling

2020 ◽  
Vol 20 (2) ◽  
pp. 156-165 ◽  
Author(s):  
Fang Peng ◽  
Chuansheng Yang ◽  
Yanan Kong ◽  
Xiaojia Huang ◽  
Yanyu Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Lung Metastasis ◽  
Xenograft Model ◽  
Breast Cancer Cell Lines ◽  
Cell Renewal ◽  
Cancer Stemness ◽  
Mesenchymal Transition ◽  
Potential Biomarker

Background: CDK12 is a promising therapeutic target in breast cancer with an effective ability of maintaining cancer cell stemness. Objective: We aim to investigate the mechanism of CDK12 in maintaining breast cancer stemness. Methods: CDK12 expression level was accessed by using RT-qPCR and IHC. CDK12-altered breast cancer cell lines MDA-MB-231-shCDK12 and SkBr-3-CDK12 were then established. CCK8, colony formation assays, and xenograft model were used to value the effect of CDK12 on tumorigenicity. Transwell assay, mammosphere formation, FACS, and lung metastasis model in vivo were determined. Western blot further characterized the mechanism of CDK12 in breast cancer stemness through the c-myc/β-catenin pathway. Results: Our results showed a higher level of CDK12 exhibited in breast cancer samples. Tumor formation, cancer cell mobility, spheroid forming, and the epithelial-mesenchymal transition will be enhanced in the CDK12high group. In addition, CDK12 was associated with lung metastasis and maintained breast cancer cell stemness. CDK12high cancer cells presented higher tumorigenicity and a population of CD44+ subset compared with CDK12low cells. Our study demonstrated c-myc positively expressed with CDK12. The c-myc/β-catenin signaling was activated by CDK12, which is a potential mechanism to initiate breast cancer stem cell renewal and may serve as a potential biomarker of breast cancer prognosis. Conclusion: CDK12 overexpression promotes breast cancer tumorigenesis and maintains the stemness of breast cancer by activating c-myc/β-catenin signaling. Inhibiting CDK12 expression may become a potential therapy for breast cancer.

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