An essential role for endogenous interferon‐
            &gamma;
            in the generation of protective T cells against
            Mycobacterium bovis
            BCG in mice

The induction of delayed-type hypersensitivity to Mycobacterium bovis BCG was specifically inhibited by suppressor T cells in C3H/He, a strain of mice which is a low responder to BCG. The existence of these suppressor cells was confirmed by an adoptive transfer of spleen cells of BCG-injected mice into cyclophosphamide-treated recipients. The suppressor cells appeared in the spleens of the mice 2 to 7 days after intravenous BCG injection. They were sensitive to anti-theta serum and complement and did not adhere to Sephadex G-10. A pretreatment of the mice with cyclophosphamide eliminated the suppression of delayed-type hypersensitivity. These suppressor cells effectively inhibited the induction of delayed-type hypersensitivity to BCG, but showed only weak effect on the expression of it.

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Human T cells recognize mycobacterial heat shock proteins in the context of multiple HLA-DR molecules: studies with healthy subjects vaccinated with Mycobacterium bovis BCG and Mycobacterium leprae.

Infection and Immunity ◽

10.1128/iai.61.12.5294-5301.1993 ◽

1993 ◽

Vol 61 (12) ◽

pp. 5294-5301 ◽

Cited By ~ 50

Author(s):

A S Mustafa ◽

K E Lundin ◽

F Oftung

Keyword(s):

T Cells ◽

Heat Shock ◽

Heat Shock Proteins ◽

Mycobacterium Bovis ◽

Healthy Subjects ◽

Mycobacterium Leprae ◽

Mycobacterium Bovis Bcg ◽

Hla Dr ◽

Human T Cells ◽

Shock Proteins

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Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-γ producing T-cells

Vaccine ◽

10.1016/j.vaccine.2008.10.034 ◽

2009 ◽

Vol 27 (1) ◽

pp. 28-37 ◽

Cited By ~ 39

Author(s):

Edgar Badell ◽

Fabienne Nicolle ◽

Simon Clark ◽

Laleh Majlessi ◽

Frédéric Boudou ◽

...

Keyword(s):

T Cells ◽

Mycobacterium Bovis ◽

Vaccine Candidate ◽

Mycobacterium Bovis Bcg ◽

Ifn Γ

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CD8+ Regulatory T Cells, and Not CD4+ T Cells, Dominate Suppressive Phenotype and Function after In Vitro Live Mycobacterium bovis-BCG Activation of Human Cells

PLoS ONE ◽

10.1371/journal.pone.0094192 ◽

2014 ◽

Vol 9 (4) ◽

pp. e94192 ◽

Cited By ~ 25

Author(s):

Mardi C. Boer ◽

Krista E. van Meijgaarden ◽

Simone A. Joosten ◽

Tom H. M. Ottenhoff

Keyword(s):

T Cells ◽

Regulatory T Cells ◽

Mycobacterium Bovis ◽

Cd4 T Cells ◽

Human Cells ◽

Mycobacterium Bovis Bcg ◽

Suppressive Phenotype ◽

And Function

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Dose-Dependent Immune Response to Mycobacterium bovis BCG Vaccination in Neonates

Clinical and Vaccine Immunology ◽

10.1128/cvi.00309-06 ◽

2006 ◽

Vol 14 (2) ◽

pp. 198-200 ◽

Cited By ~ 6

Author(s):

Virginia Davids ◽

Willem Hanekom ◽

Sebastian J. Gelderbloem ◽

Anthony Hawkridge ◽

Gregory Hussey ◽

...

Keyword(s):

Immune Response ◽

T Cells ◽

T Cell ◽

Mycobacterium Bovis ◽

Whole Blood ◽

Cell Frequency ◽

Mycobacterium Bovis Bcg ◽

Bcg Vaccination ◽

Cytokine Levels ◽

Dose Dependent

ABSTRACT In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4+ T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4+ T-cell frequency after 12 h of BCG stimulation.

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