Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity

Vaccine ◽  
2007 ◽  
Vol 25 (50) ◽  
pp. 8384-8394 ◽  
Author(s):  
Janice J. Endsley ◽  
Alison Hogg ◽  
Lis J. Shell ◽  
Martin McAulay ◽  
Tracey Coffey ◽  
...  
Keyword(s):  
T Cells ◽  
Mycobacterium Bovis ◽  
Cd4 T Cells ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Memory Cd4 T Cells

scholarly journals Polyfunctional CD4 T-cells correlate with in vitro mycobacterial growth inhibition following Mycobacterium bovis BCG-vaccination of infants

Vaccine ◽  
2016 ◽  
Vol 34 (44) ◽  
pp. 5298-5305 ◽  
Author(s):  
Steven G. Smith ◽  
Andrea Zelmer ◽  
Rose Blitz ◽  
Helen A. Fletcher ◽  
Hazel M. Dockrell
Keyword(s):  
T Cells ◽  
Growth Inhibition ◽  
Mycobacterium Bovis ◽  
Cd4 T Cells ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Mycobacterial Growth

scholarly journals Dose-Dependent Immune Response to Mycobacterium bovis BCG Vaccination in Neonates

2006 ◽  
Vol 14 (2) ◽  
pp. 198-200 ◽  
Author(s):  
Virginia Davids ◽  
Willem Hanekom ◽  
Sebastian J. Gelderbloem ◽  
Anthony Hawkridge ◽  
Gregory Hussey ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
T Cell ◽  
Mycobacterium Bovis ◽  
Whole Blood ◽  
Cell Frequency ◽  
Mycobacterium Bovis Bcg ◽  
Bcg Vaccination ◽  
Cytokine Levels ◽  
Dose Dependent

ABSTRACT In 10-week-old infants vaccinated at birth with Japanese Mycobacterium bovis BCG, the number of dermal needle penetrations correlated positively with frequency of proliferating CD4+ T cells in whole blood following BCG stimulation for 6 days but did not correlate with secreted cytokine levels after 7 h or interferon CD4+ T-cell frequency after 12 h of BCG stimulation.

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