scholarly journals Localization of the Brain Lesion Affects the Lateralization of T‐Lymphocyte Dependent Cutaneous Inflammation. Evidence for an Immunoregulatory Role of the Right Frontal Cortex–Putamen Region

1998 ◽  
Vol 47 (1) ◽  
pp. 30-36 ◽  
Author(s):  
Tarkowski ◽  
Jensen ◽  
Ekholm ◽  
Ekelund ◽  
Blomstrand ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
T Lymphocyte ◽  
Brain Lesion ◽  
Cutaneous Inflammation ◽  
The Right ◽  
The Brain

scholarly journals Reducing future fears by suppressing the brain mechanisms underlying episodic simulation

2016 ◽  
Vol 113 (52) ◽  
pp. E8492-E8501 ◽  
Author(s):  
Roland G. Benoit ◽  
Daniel J. Davies ◽  
Michael C. Anderson
Keyword(s):  
Prefrontal Cortex ◽  
Dorsolateral Prefrontal Cortex ◽  
Ventromedial Prefrontal Cortex ◽  
Episodic Simulation ◽  
Dorsolateral Prefrontal ◽  
Future Events ◽  
The Right ◽  
Development Of Anxiety ◽  
The Brain

Imagining future events conveys adaptive benefits, yet recurrent simulations of feared situations may help to maintain anxiety. In two studies, we tested the hypothesis that people can attenuate future fears by suppressing anticipatory simulations of dreaded events. Participants repeatedly imagined upsetting episodes that they feared might happen to them and suppressed imaginings of other such events. Suppressing imagination engaged the right dorsolateral prefrontal cortex, which modulated activation in the hippocampus and in the ventromedial prefrontal cortex (vmPFC). Consistent with the role of the vmPFC in providing access to details that are typical for an event, stronger inhibition of this region was associated with greater forgetting of such details. Suppression further hindered participants’ ability to later freely envision suppressed episodes. Critically, it also reduced feelings of apprehensiveness about the feared scenario, and individuals who were particularly successful at down-regulating fears were also less trait-anxious. Attenuating apprehensiveness by suppressing simulations of feared events may thus be an effective coping strategy, suggesting that a deficiency in this mechanism could contribute to the development of anxiety.

scholarly journals The Great Debate at ‘Immunotherapy Bridge’, Naples, December 5, 2019

2020 ◽  
Vol 8 (2) ◽  
pp. e000921
Author(s):  
Paolo A Ascierto ◽  
Carlo Bifulco ◽  
Jerome Galon ◽  
Claus Garbe ◽  
Samir N Khleif ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Cell Therapy ◽  
T Lymphocyte ◽  
Chimeric Antigen Receptor ◽  
Cellular Cytotoxicity ◽  
Antibody Dependent Cellular Cytotoxicity ◽  
T Cell Therapy ◽  
Great Debate ◽  
The Brain

As part of the 2019 Immunotherapy Bridge congress (December 4–5, Naples, Italy), the Great Debate session featured counterpoint views from leading experts on six topical issues in immunotherapy today. These were the use of chimeric antigen receptor T cell therapy in solid tumors, whether the Immunoscore should be more widely used in clinical practice, whether antibody-dependent cellular cytotoxicity is important in the mode of action of anticytotoxic T-lymphocyte-associated protein 4 antibodies, whether the brain is immunologically unique or just another organ, the role of microbiome versus nutrition in affecting responses to immunotherapy, and whether chemotherapy is immunostimulatory or immunosuppressive. Discussion of these important topics are summarized in this report.

Identifying neuroanatomical signatures in insomnia and migraine comorbidity

SLEEP ◽  
2020 ◽  
Author(s):  
Kun-Hsien Chou ◽  
Pei-Lin Lee ◽  
Chih-Sung Liang ◽  
Jiunn-Tay Lee ◽  
Hung-Wen Kao ◽  
...  
Keyword(s):  
Large Scale ◽  
Gray Matter Volume ◽  
Brain Structures ◽  
Brain Network ◽  
Structural Covariance ◽  
Matter Volume ◽  
The Right ◽  
Global Brain ◽  
The Brain

Abstract Study Objectives While insomnia and migraine are often comorbid, the shared and distinct neuroanatomical substrates underlying these disorders and the brain structures associated with the comorbidity are unknown. We aimed to identify patterns of neuroanatomical substrate alterations associated with migraine and insomnia comorbidity. Methods High-resolution T1-weighted images were acquired from subjects with insomnia, migraine, and comorbid migraine and insomnia, respectively, and healthy controls (HC). Direct group comparisons with HC followed by conjunction analyses identified shared regional gray matter volume (GMV) alterations between the disorders. To further examine large-scale anatomical network changes, a seed-based structural covariance network (SCN) analysis was applied. Conjunction analyses also identified common SCN alterations in two disease groups, and we further evaluated these shared regional and global neuroanatomical signatures in the comorbid group. Results Compared with controls, patients with migraine and insomnia showed GMV changes in the cerebellum and the lingual, precentral, and postcentral gyri (PCG). The bilateral PCG were common GMV alteration sites in both groups, with decreased structural covariance integrity observed in the cerebellum. In patients with comorbid migraine and insomnia, shared regional GMV and global SCN changes were consistently observed. The GMV of the right PCG also correlated with sleep quality in these patients. Conclusion These findings highlight the specific role of the PCG in the shared pathophysiology of insomnia and migraine from a regional and global brain network perspective. These multilevel neuroanatomical changes could be used as potential image markers to decipher the comorbidity of the two disorders.

Regulation of metallothionein concentrations in rat brain: effect of glucocorticoids, zinc, copper, and endotoxin

1994 ◽  
Vol 266 (5) ◽  
pp. E760-E767 ◽  
Author(s):  
T. Gasull ◽  
M. Giralt ◽  
J. Hernandez ◽  
P. Martinez ◽  
I. Bremner ◽  
...  
Keyword(s):  
Frontal Cortex ◽  
Rat Brain ◽  
Medulla Oblongata ◽  
Adrenocorticotropic Hormone ◽  
Brain Areas ◽  
Deficient Diet ◽  
Zinc Deficient Diet ◽  
The Brain

The effects of known inducers of liver metallothionein (MT) synthesis on MT concentrations in the rat brain have been determined using antibodies that are specific for MT I and II and do not cross-react with MT III. There were substantial differences in the MT concentrations in different areas of the brain. Dexamethasone increased MT levels after 24 h in the frontal cortex, cortex, medulla oblongata plus pons, midbrain, striatum, hippocampus, and cerebellum but not in the hypothalamus. Corticosterone produced similar results except in the hippocampus. Long-lasting adrenocorticotropic hormone increased MT concentrations after 12 h in midbrain and striatum but not in the liver. Adrenalectomy decreased MT concentrations after 6 days in the medulla oblongata plus pons, striatum, hippocampus, and hypothalamus but increased concentrations in the liver and kidneys; these effects were reversed by corticosterone. The role of glucocorticoids in the regulation of MT levels therefore differs between tissues and within specific areas of the brain. Injection of zinc or copper intracerebroventricularly and the use of a zinc-deficient diet increased and decreased MT levels, respectively, in some but not all brain areas. Endotoxin increased liver MT but not brain MT I levels after 8 h.

Medicines—general principles

2021 ◽  
pp. 147-155
Author(s):  
Mark Selikowitz
Keyword(s):  
Social Skills ◽  
Emotional State ◽  
Frontal Lobes ◽  
Learning Behaviour ◽  
Children With Adhd ◽  
Adhd Treatment ◽  
The Right ◽  
The Brain

All the medicines used to treat ADHD aim to normalize the amount of neurotransmitter in the frontal lobes of the brain. Each child with ADHD needs medication that is selected with care and based on several considerations. Medicine can potentially reduce many difficulties experienced by children with ADHD, although some may not need medication. This chapter discusses medicines in the treatment of ADHD, including how they work, how to find the right medicine for a particular child and aspects of ADHD that are helped by medicines (learning, behaviour, social skills, emotional state). It also covers the place of medicine in the treatment of ADHD, treatment of ADHD without medication, and how to explain the role of medications to a child.

scholarly journals The Brain-Heart Connection: Frontal Cortex and Left Ventricle Angiotensinase Activities in Control and Captopril-Treated Hypertensive Rats—A Bilateral Study

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Ana B. Segarra ◽  
Isabel Prieto ◽  
Inmaculada Banegas ◽  
Ana B. Villarejo ◽  
Rosemary Wangensteen ◽  
...  
Keyword(s):  
Drinking Water ◽  
Left Ventricle ◽  
Frontal Cortex ◽  
Treated Group ◽  
The Other ◽  
Hypertensive Rats ◽  
Membrane Bound ◽  
Left And Right ◽  
The Right ◽  
The Brain

The model ofneurovisceral integrationsuggests that the frontal cortex (FC) and the cardiovascular function are reciprocally and asymmetrically connected. We analyzed several angiotensinase activities in the heart left ventricle (VT) of control and captopril-treated SHR, and we search for a relationship between these activities and those determined in the left and right FC. Captopril was administered in drinking water for 4 weeks. Samples from the left VT and from the left and right FC were obtained. Soluble and membrane-bound enzymatic activities were measured fluorometrically using arylamides as substrates. The weight of heart significantly decreased after treatment with captopril, mainly, due to the reduction of the left VT weight. In the VT, no differences for soluble activities were observed between control and treated SHR. In contrast, a generalized significant reduction was observed for membrane-bound activities. The most significant correlations between FC and VT were observed in the right FC of the captopril-treated group. The other correlations, right FC versus VT and left FC versus VT in controls and left FC versus VT in the captopril group, were few and low. These results confirm that the connection between FC and cardiovascular system is asymmetrically organized.

scholarly journals Why is L1 not easy to hear?

2020 ◽  
Vol 5 (1) ◽  
pp. 59
Author(s):  
Shinobu Mizuguchi ◽  
Koichi Tateishi
Keyword(s):  
Neural Networks ◽  
Frontal Cortex ◽  
Superior Temporal Gyrus ◽  
The Other ◽  
Contrastive Focus ◽  
Other Hand ◽  
Pitch Contours ◽  
Fmri Experiment ◽  
The Right ◽  
The Brain

We naively believe that L1 is easier to hear than L2. Generally, this belief is correct, but not always. Japanese contrastive focus is more challenging to identify than English focus even for L1 speakers.  To account for why Japanese is hard to perceive, we first conducted production and perception experiments, to understand linguistic mechanisms.  We found that Japanese lacks a part of focus effects and is an acoustically weak language contra previous studies. English, on the other hand, is an acoustically strong language and uses the F0 feature as a focus cue. We then conducted an fMRI experiment to see whether or not linguistic mechanisms for them are implemented in the brain. We found that we employ different neural networks to process English and Japanese; the right dorsolateral frontal cortex is activated to process Japanese CF, but not English CF. Japanese is a pitch language and requires processing both lexical accents and pitch contours. English, on the other hand, needs to process lexical accent only, and it activates left superior temporal gyrus, insular, and supramargical regions, but not right dorsolateral frontal cortex. We conclude that processing burdens lead to perception difficulty, even for L1 Japanese speakers.

scholarly journals The role of neurotransmitter systems separate the hemispheres of the brain in action the new antiepileptic compounds AGB-31

2013 ◽  
Vol 11 (2) ◽  
pp. 31-35
Author(s):  
Oleg Aleksandrovich Yarosh
Keyword(s):  
Nitric Oxide ◽  
Left Hemisphere ◽  
Glutamic Acid Decarboxylase ◽  
Right Hemisphere ◽  
Reduced Glutathione ◽  
Acid Decarboxylase ◽  
Decarboxylase Activity ◽  
The Right ◽  
The Brain

Compound AGB-31, a monocarbamate derivative, is shown to possess a high antiepileptic activity. The mechanisms of antiepileptic action are connected with significant increase in glutamic acid decarboxylase activity in the left hemisphere of the brain, with trend of the glutamate content decrease in the left hemisphere and the tendency to increase GABA in both hemispheres. AGB-31 significantly (more than 3-fold) increases syntase nitric oxide activity in the left hemisphere and has a tendency to reduce the NO content in both hemispheres. AGB-31 significantly (by 63.4%), reduced glutathione peroxydase activity in the right hemisphere without changing it in the left, with a tendency to increase the activity of glutathione reductase in both hemispheres.

scholarly journals Damage to the right insula disrupts the perception of affective touch

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Louise P Kirsch ◽  
Sahba Besharati ◽  
Christina Papadaki ◽  
Laura Crucianelli ◽  
Sara Bertagnoli ◽  
...  
Keyword(s):  
Right Hemisphere ◽  
Anterior Insula ◽  
Affective Touch ◽  
Cortical Organization ◽  
Touch Perception ◽  
Posterior Insula ◽  
The Right ◽  
Tactile System ◽  
The Brain

Specific, peripheral C-tactile afferents contribute to the perception of tactile pleasure, but the brain areas involved in their processing remain debated. We report the first human lesion study on the perception of C-tactile touch in right hemisphere stroke patients (N = 59), revealing that right posterior and anterior insula lesions reduce tactile, contralateral and ipsilateral pleasantness sensitivity, respectively. These findings corroborate previous imaging studies regarding the role of the posterior insula in the perception of affective touch. However, our findings about the crucial role of the anterior insula for ipsilateral affective touch perception open new avenues of enquiry regarding the cortical organization of this tactile system.

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