Histologically low-grade dedifferentiated liposarcoma of the retroperitoneum

Dedifferentiated liposarcoma is a nonlipogenic sarcoma of variable histological grade that frequently arises in association with a well-differentiated liposarcoma. Dedifferentiation occurs in approximately 10% of well-differentiated liposarcomas and is most commonly encountered in the retroperitoneum. Dedifferentiated liposarcoma of the upper respiratory tract is an extremely rare occurrence. Herein, we report a very rare case of low-grade dedifferentiated liposarcoma of the pharynx that presented as a polyp mimicking a benign process clinically and microscopically. We discuss the relevant molecular findings and review the current literature.

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Dedifferentiated liposarcoma with abrupt transition of low-grade and high-grade dedifferentiation: A rare case report

International Journal of Immunopathology and Pharmacology ◽

10.1177/20587384211048565 ◽

2021 ◽

Vol 35 ◽

pp. 205873842110485

Author(s):

Yang Wen ◽

Xianglei He ◽

Ming Zhao

Keyword(s):

Case Report ◽

Rare Case ◽

Dedifferentiated Liposarcoma ◽

Low Grade ◽

High Grade ◽

Sharp Transition ◽

Abrupt Transition ◽

Rare Case Report ◽

Histological Heterogeneity ◽

Histological Morphology

Dedifferentiated liposarcoma is a unique subtype of liposarcoma, which has obvious histological heterogeneity. In affected patients, the condition typically manifests as the dedifferentiation of high-grade histological morphology, but it may also manifest as the dedifferentiation of low-grade histological morphology. In some cases, unique histological or immunophenotypic characteristics are observed. We describe, herein, a rare case of dedifferentiated liposarcoma, in which the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology.

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GENE EXPRESSION ANALYSIS OF A DEDIFFERENTIATED LIPOSARCOMA — DIFFERENCES BETWEEN HIGH AND LOW GRADE AREAS: ANALYSIS OF TWO CASES AND LITERATURE REVIEW

Journal of Musculoskeletal Research ◽

10.1142/s0218957705001412 ◽

2005 ◽

Vol 09 (01) ◽

pp. 9-20 ◽

Cited By ~ 2

Author(s):

Meera R. Hameed ◽

Tao-Zhen Lin ◽

Frederick Coffman ◽

Marion C. Cohen ◽

Helen Fernandes ◽

...

Keyword(s):

Differentially Expressed Genes ◽

Expression Patterns ◽

Soft Tissue Sarcomas ◽

Differentially Expressed ◽

Dedifferentiated Liposarcoma ◽

Biological Behavior ◽

Low Grade ◽

High Grade ◽

High Grade Sarcoma ◽

Well Differentiated

The phenomenon of dedifferentiation typically occurs in soft tissue sarcomas where a low grade or well-differentiated tumor shows an abrupt transformation to a high-grade sarcoma without lineage specificity. The biological behavior and metastatic potential of these tumors is dictated by the dedifferentiated phenotype. Tumor material was available from two dedifferentiated liposarcomas. We performed cDNA microarray analysis of a dedifferentiated liposarcoma in which the atypical lipomatous/well-differentiated and dedifferentiated portions were grossly distinct, to find differentially expressed genes in the dedifferentiated component compared to the well-differentiated component. There were 100 differentially expressed genes, both up- and down-regulated in the high grade sarcoma. In addition, we performed RT-PCR on selected genes in both cases to confirm the microarray findings. We discuss the expression patterns of these genes in comparison to other studies in the literature.

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Dedifferentiated liposarcoma of the retro-peritoneum: Histologically low-grade type

Indian Journal of Pathology and Microbiology ◽

10.4103/0377-4929.64347 ◽

2010 ◽

Vol 53 (2) ◽

pp. 353 ◽

Cited By ~ 1

Author(s):

RugveditaSatyajeet Parakh ◽

MeeraPrem Zawar ◽

PradeepAchyut Gadgil ◽

NeerajaShashikant Kaujalagi

Keyword(s):

Dedifferentiated Liposarcoma ◽

Low Grade

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Dedifferentiated liposarcoma with abrupt transition of low-grade and high-grade dedifferentiated components: A case report

10.21203/rs.3.rs-275923/v1 ◽

2021 ◽

Author(s):

YANG WEN ◽

XIANGLEI HE ◽

MING ZHAO

Keyword(s):

Abdominal Mass ◽

Dedifferentiated Liposarcoma ◽

Fish Analysis ◽

Low Grade ◽

High Grade ◽

Sharp Transition ◽

Mdm2 Gene ◽

Magnetic Resonance Imaging Mri ◽

Histological Heterogeneity ◽

Histological Morphology

Abstract BackgroundDedifferentiated liposarcoma (DDLPS) is a unique subtype of liposarcoma, which has obvious histological heterogeneity. In affected patients, the condition typically manifests as the dedifferentiation of high-grade histological morphology, but it may also manifest as the dedifferentiation of low-grade histological morphology. In some cases, unique histological or immunophenotypic characteristics are observed. We describe, herein, a rare case of dedifferentiated liposarcoma, in which the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology.Case presentationA 69-year-old woman with severe abdominal pain lasting for 1 hour presented to our hospital. Physical examination revealed a mobile large left abdominal mass, Magnetic resonance imaging (MRI) scan showed a huge mass with typical fat components and the non-fatty nodule in the left retroperitoneal cavity. After laparotomy, histologic analysis of the specimens could find the atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) and DDLPS components. Fluorescence in situ hybridization (FISH) analysis suggested the presence of MDM2 gene amplification. These findings supported a diagnosis of DDLPS.ConclusionIn our case, the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology. We hypothesize that low-grade dedifferentiation may be a precursor to high-grade dedifferentiation. MRI images cannot distinguish the two components.

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Borderline Sign of A Rare Dedifferentiated Liposarcoma: Report of A Case

10.21203/rs.3.rs-40712/v1 ◽

2020 ◽

Author(s):

Yang Wen ◽

Songhua Fang ◽

Ming Zhao ◽

Xianglei He

Keyword(s):

Abdominal Mass ◽

Tumor Resection ◽

Dedifferentiated Liposarcoma ◽

Resected Specimen ◽

Fish Analysis ◽

Low Grade ◽

High Grade ◽

Mdm2 Gene ◽

Rare Type ◽

Histological Morphology

Abstract Background: Dedifferentiated liposarcoma (DDLPS) is a unique subtype of liposarcoma, which has obvious histological heterogeneity. Most of them manifested as the dedifferentiation of high-grade histological morphology, but a few could be the dedifferentiation of low-grade histological morphology, or present as some special types of histological or immunophenotypic characteristics. We describe, herein, a case of rare type of dedifferentiated liposarcoma, in which the dedifferentiated components are high-grade and low-grade coexisting with a relatively sharp transition.Case presentation: A 69-year-old woman with severe abdominal pain lasting for 1 hour presented to our hospital. Physical examination revealed a mobile large left abdominal mass, which was shown on abdominal CT and MRI as a huge retroperitoneal tumor with lipogenic component and solid nonlipogenic components. Tumor resection was performed. Gross examination of the resected specimen showed the gray yellow fatty mass and a round like solid nodule adjacent to the fatty mass, the cut surface of the nodule was gray-white or fish flesh color, and gray yellow in the nodular center. Microscopic examination demonstrated the tumor contains the well-differentiated liposarcoma (WDLPS) component and the DDLPS component. The latter was composed of coexisting high-grade and low-grade components in which multiple focal regions of a sudden transition between the high-grade and the low-grade dedifferentiated component were identified. Immunohistochemistry showed that P16, CDK4, and MDM2 were diffusely positive. The FISH analysis revealed the presence of MDM2 gene amplification in the nuclei of the atypical cells. A final diagnosis of DDLPS was rendered.Conclusion: In our case, the borderline sign between the high-grade and low-grade dedifferentiated components in the histology may indicate that there can be obvious differentiation lines in tumor dedifferentiation, which is classically and typically abrupt. Low-grade dedifferentiation may be a precursor lesion of high-grade dedifferentiation. MRI images cannot distinguish the two components.

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Significance of LRP and PPAR-γ Expression in Lipomatous Soft Tissue Tumors

The Open Orthopaedics Journal ◽

10.2174/1874325001004010048 ◽

2010 ◽

Vol 4 (1) ◽

pp. 48-55 ◽

Cited By ~ 3

Author(s):

Takashi Tajima ◽

Takeshi Morii ◽

Fumihito Kikuchi ◽

Akihiko Matsumine ◽

Hiroaki Murata ◽

...

Keyword(s):

Density Lipoprotein ◽

Myxoid Liposarcoma ◽

Expression Level ◽

Dedifferentiated Liposarcoma ◽

Low Grade ◽

Peroxisome Proliferator ◽

Peroxisome Proliferator Activated Receptor ◽

Pleomorphic Liposarcoma ◽

Ppar Γ ◽

Well Differentiated

Background: Molecular mechanism of differentiation in lipogenic tumor is still unknown in detail. Low-density lipoprotein receptor-related protein (LRP) and peroxisome proliferator-activated receptor gamma (PPAR-γ), representative regulatory molecules of lipogenic differentiation, have been reported today as multi-functional molecules and to modulate tumorigenesis in various kind of cancer. To date, diagnostic and therapeutic significance of the expression of these molecules in lipogenic tumors are not defined. Methods: The immunohistochemical expression status of LRP and PPAR-γ in various grades of 54 lipogenic tumors was analyzed. Correlation between the expression levels and the differentiation of the tumors was confirmed. For statistical analyses, the Kruskal-Wallis test, the Steel-Dwass test and the Mann–Whitney U test were used. Results: LRP and PPAR-γ expression was detected in 50 (92.6%) and 44 (81.5%) cases, respectively. The expression level in LRP was significantly higher in cases with well differentiated liposarcoma, pleomorphic liposarcoma and dedifferentiated liposarcoma than in lipoma. Compared with lipoma or well differentiated liposarcoma, significant elevation in expression level of PPAR-γ was confirmed in myxoid liposarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma and the differentiated area of dedifferentiated liposarcoma. Conclusion: The up-regulation of LRP and PPAR-γ in higher grade cases, i.e. less differentiated tumors than in low grade cases was shown, suggesting the candidate role of these molecules as tumor progression modulators rather than regulatory molecules of differentiation in lipogenic tumors.

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Dedifferentiated Liposarcoma with Abrupt Transition of Low-Grade and High-Grade Dedifferentiated Components ：A Case Report

10.21203/rs.3.rs-108091/v1 ◽

2020 ◽

Author(s):

YANG WEN ◽

XIANGLEI HE ◽

MING ZHAO

Keyword(s):

Abdominal Mass ◽

Dedifferentiated Liposarcoma ◽

Fish Analysis ◽

Low Grade ◽

High Grade ◽

Sharp Transition ◽

Mdm2 Gene ◽

Magnetic Resonance Imaging Mri ◽

Histological Heterogeneity ◽

Histological Morphology

Abstract Background: Dedifferentiated liposarcoma (DDLPS) is a unique subtype ofliposarcoma, which has obvious histological heterogeneity. In affected patients, the condition typically manifests as the dedifferentiation of high-grade histological morphology, but it may also manifest as the dedifferentiation of low-grade histological morphology. In some cases, unique histological or immunophenotypic characteristics are observed. We describe, herein, a rare case of dedifferentiated liposarcoma, in which the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology.Case presentation: A 69-year-old woman with severe abdominal pain lasting for 1 hour presented to our hospital. Physical examination revealed a mobile large left abdominal mass, Magnetic resonance imaging (MRI) scan showed a huge mass with typical fat components and the non-fatty nodule in the left retroperitoneal cavity. After laparotomy, histologic analysis of the specimens could find the ALT/WDLPS and DDLPS components. Fluorescence in situ hybridization (FISH) analysis suggested the presence of MDM2 gene amplification. These findings supported a diagnosis of DDLPS.Conclusion: In our case, the high-grade and low-grade dedifferentiated components coexisted with a relatively sharp transition in pathology. We hypothesize that low-grade dedifferentiation may be a precursor to high-grade dedifferentiation. MRI images cannot distinguish the two components.

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