Squamous cell carcinoma of the bladder, intermittent self-catheterization and urinary tract infection-is there an association?

INTRODUCTION The aim of this study was to investigate the prevalence of risk factors for primary squamous cell carcinoma (SCC) of the bladder. MATERIALS A total of 90 cases of primary SCC of the bladder were identified through multicentre analysis. Patient demographics, stage and grade of cancer at presentation, management and outcomes were recorded. The presence of known risk factors (catheter use, neuropathic bladder, smoking history, recurrent urinary tract infection and bladder stones) was also documented. RESULTS Over half of the patients had at least one identifiable risk factor for the development of primary bladder SCC: 13.9% of patients had a history of catheter use (clean intermittent self-catheterisation [CISC] in 11.1%), 10.0% of patients had a neuropathic bladder, 27.8% were smokers or ex-smokers and 20.0% had a documented history of recurrent urinary tract infection. Statistical analysis of the results showed no association between risk factors and grade of tumour at presentation. CONCLUSIONS These data further support the association between primary bladder SCC and several of the well documented risk factors for its development. Chronic use of CISC may confer a greater risk for development of SCC than thought previously. Further evidence of the role of CISC in primary SCC is required to justify routine screening and to determine exactly when surveillance of the bladder should begin for this group of patients.

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The Influence of Lower Urinary Tract Infection on the Recurrence Rate of Superficial Transitional Cell Carcinoma of the Bladder

The Journal of Urology ◽

10.1016/s0022-5347(17)51398-1 ◽

1983 ◽

Vol 130 (4) ◽

pp. 674-676 ◽

Cited By ~ 1

Author(s):

I. Nissenkorn ◽

D. Slutzker ◽

E. Schujman ◽

C. Servadio

Keyword(s):

Urinary Tract Infection ◽

Urinary Tract ◽

Tract Infection ◽

Transitional Cell Carcinoma ◽

Cell Carcinoma ◽

Lower Urinary Tract ◽

Transitional Cell ◽

Lower Urinary Tract Infection ◽

Carcinoma Of The Bladder ◽

Lower Urinary

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Bladder squamous cell carcinoma in a pregnant woman: case report and review of the literature

BMC Urology ◽

10.1186/s12894-020-00772-6 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Pablo A. Rojas ◽

Cristián González ◽

Gonzalo P. Mendez ◽

Alejandro Majerson ◽

Ignacio F. San Francisco

Keyword(s):

Squamous Cell Carcinoma ◽

Bladder Cancer ◽

Pregnant Woman ◽

Urinary Tract ◽

Cell Carcinoma ◽

Radical Cystectomy ◽

Squamous Cell ◽

Pet Ct ◽

Cell Bladder Cancer ◽

Urinary Tract Reconstruction

Abstract Background Bladder tumors in pregnancy are extremely rare. No more than 50 cases have been published to date, including all histologic variants, and only three cases of bladder squamous cell carcinoma have been described. Case presentation We present a clinical case of a 31-year-old woman with bladder squamous cell carcinoma in the second trimester of pregnancy. After a C-section at 30 weeks, we performed radical cystectomy with extended bilateral lymphadenectomy, hysterectomy and right oophorectomy. The Studer neobladder technique was performed for urinary tract reconstruction. Definitive pathology showed invasive bladder squamous cell carcinoma, Grade 2, with microscopic infiltration of the perivesical fat, negative margins, and 3/28 lymph nodes with carcinoma (pT3aN2M0). The patient underwent 18 months of surveillance after radical cystectomy, without recurrence by PET-CT. Conclusions Bladder cancer in pregnant women is extremely rare but must be considered in those with recurrent gross hematuria and/or recurrent urinary tract infection. To our knowledge, this case involves the longest recurrence-free survival of a pregnant woman with squamous cell bladder cancer published thus far.

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Ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation: a case report

BMC Surgery ◽

10.1186/s12893-021-01099-1 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Shangqing Ren ◽

Hualin Feng ◽

Yige Bao ◽

Yi Wei ◽

Yong Ou ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Urinary Tract ◽

Urothelial Carcinoma ◽

Cell Carcinoma ◽

Squamous Cell ◽

Standard Treatment ◽

Clinical Manifestations ◽

Sarcomatoid Carcinoma ◽

Upper Urinary Tract ◽

Malignant Tumours

Abstract Background Upper urinary tract urothelial carcinoma (UTUC) with multiple pathological types is extremely rare in the clinic, but the recurrence rate and mortality these patients are high. At present, there is no standard treatment for such cases. Case presentation We reported a case of ureteral urothelial carcinoma with squamous cell carcinoma and sarcomatoid carcinoma differentiation and rapid ileal metastasis and reviewed the literature related to different pathological types of upper urinary tract tumours to explore the diagnosis, treatment and prognosis characteristics of the disease, enhance our understanding of its clinical manifestations and history of evolution and provide guidance for avoiding missed diagnosis and misdiagnosis. Conclusion There is no standard treatment for urinary malignant tumours with multiple pathological types; radical surgery is considered a suitable choice. Chemotherapy, targeted drug therapy and immunotherapy may be beneficial to the survival of patients. In short, these patients have a high risk of recurrence and metastasis and a poor prognosis.

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