Serum interleukin-6 levels and bone mineral density at the femoral neck in post-menopausal women with Type 1 diabetes

Abstract Background and aims: Type 1 diabetes mellitus (T1DM) represents a secondary cause of osteoporosis. Our aim was to determine bone mineral density (BMD) changes in a group of young Romanian adults with T1DM and to analyze the factors related to this disease that could have had an impact on bone mass. Material and Methods: Fifty-two young patients with T1DM were compared to 37 healthy volunteers matched for body mass index (BMI). All subjects had their BMD measured at the hip and lumbar spine. Results: We found no statistically significant differences in BMD between T1DM patients and controls (p=0.618 for lumbar spine, p=0.974 for femoral neck and p=0.883 for total hip). Multiple linear regression models detected BMI (p =0.043), smoking (p=0.001) and milk intake (p=0.004 for lumbar spine) as significant BMD determinants. In contrast, no associations were found between BMD and metabolic control, daily insulin dose or presence of diabetic retinopathy and/or neuropathy. Long diabetes duration was negatively associated with BMD in femoral neck (p=0.012). Conclusions: Although we couldn’t find differences between BMD in T1DM patients and controls, the link between diabetes duration and BMD that we found suggests that even young patients with long standing T1DM should have their BMD measured

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Association between BMI and femoral neck bone mineral density in post-menopausal women: analysis of NHANES cross sectional data 2008-2012

Endocrine Abstracts ◽

10.1530/endoabs.37.ep242 ◽

2015 ◽

Author(s):

Sangeeta Chandramahanti ◽

Henry Driscoll ◽

Adenrele Olajide ◽

Omolola Olajide ◽

Ralph Webb ◽

...

Keyword(s):

Bone Mineral Density ◽

Femoral Neck ◽

Bone Mineral ◽

Mineral Density ◽

Cross Sectional ◽

Menopausal Women ◽

Post Menopausal

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Bone mineral density at femoral neck and lumbar spine in adults with type 1 diabetes: a meta-analysis and review of the literature

Osteoporosis International ◽

10.1007/s00198-017-4097-x ◽

2017 ◽

Vol 28 (9) ◽

pp. 2601-2610 ◽

Cited By ~ 34

Author(s):

V. N. Shah ◽

K. K. Harrall ◽

C. S. Shah ◽

T. L. Gallo ◽

P. Joshee ◽

...

Keyword(s):

Bone Mineral Density ◽

Type 1 Diabetes ◽

Lumbar Spine ◽

Femoral Neck ◽

Bone Mineral ◽

Meta Analysis ◽

Review Of The Literature ◽

Mineral Density

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Brisk Walking Reduces Calcaneal Bone Loss in Post-Menopausal Women

Clinical Science ◽

10.1042/cs0920075 ◽

1997 ◽

Vol 92 (1) ◽

pp. 75-80 ◽

Cited By ~ 44

Author(s):

Katherine Brooke-Wavell ◽

Peter R. M. Jones ◽

Adrianne E. Hardman

Keyword(s):

Bone Mineral Density ◽

Lumbar Spine ◽

Bone Loss ◽

Femoral Neck ◽

Bone Mineral ◽

Brisk Walking ◽

Mineral Density ◽

Control Subjects ◽

Menopausal Women ◽

Post Menopausal

1. This study examined the influence of brisk walking on skeletal status in post-menopausal women. 2. Subjects were 84 healthy women aged 60–70 years who were previously sedentary and at least 5 years post-menopausal. Subjects were randomly assigned to walking (n = 43) and control (n = 41) groups. Walkers followed a 12-month, largely unsupervised programme of brisk walking. The bone mineral density of the lumbar spine, femoral neck and calcaneus and broadband ultrasonic attention of the calcaneus were measured at baseline and after 12 months. 3. Forty control subjects and 38 walkers completed the study. Walkers built up to 20.4 ± 3.8 min/day (mean ± SD) of brisk walking. Body mass increased in control subjects relative to walkers [mean change (SE) ± 0.9 (0.3) and −0.1 (0.3) kg respectively; P = 0.04]. Predicted maximum oxygen uptake increased in walkers by 2.1 (0.9) ml min−1 kg−1 (P = 0.02). Bone mineral density in the lumbar spine and calcaneus fell in control subjects [–0.005 (0.004) and −0.010 (0.004) g/cm2, respectively] but not in walkers [+0.006 (0.004) and +0.001 (0.004) g/cm2]. The difference in response between groups was significant in the calcaneus (P = 0.04) but not in the lumbar spine (P = 0.08). Mean femoral neck bone mineral density did not change significantly in either group, although changes in walkers were related to the amount of walking completed (r = 0.51, P = 0.001). The change in broadband ultrasonic attenuation of the calcaneus differed between groups [control subjects, −3.7 (0.8); walkers, −0.7 (0.8) dB/MHz; P = 0.01]. 4. Walking decreased bone loss in the calcaneus and possibly in the lumbar spine. It also improved functional capacity and enabled walkers to avoid the increase in body mass seen in control subjects.

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Change in Bone Mineral Density in Post Menopausal Women with Rheumatoid Arthritis

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v12i2.14944 ◽

2013 ◽

Vol 12 (2) ◽

pp. 158-163

Author(s):

Mehrdad Aghaei ◽

Sima Sedighi ◽

Naser Behnampour ◽

Sharabeh Hezarkhani ◽

Mona Shirashiani ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Bone Mineral Density ◽

Femoral Neck ◽

Postmenopausal Women ◽

Bone Mineral ◽

Statistical Tests ◽

Mineral Density ◽

Menopausal Women ◽

Duration Of Disease ◽

Post Menopausal

Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis. Methods: This retrospective cohort study was carried out on consecutive postmenopausal women with rheumatoid arthritis who were referred to the Azar 5th teaching hospital affiliated to Golestan University of Medical Sciences, North of Iran in 2009. The required data were gathered from the patients medical records. The data were analyzed using SPSS software and statistical tests. Results: We studied 98 postmenopausal women with rheumatoid arthritis. Mean number of years since menopause and mean duration of disease were 9.39 and 5.13 respectively. T Score mean in femoral neck and lumbar spines was -1.45±1.26 and -2.45±1.44 respectively. The overall prevalence of osteoporosis at both the lumbar spine and femoral neck was 13.3. We have found a significant correlation between age, duration of disease, duration of menopause and bone mineral density (P-Value<0.01). Conlusion: Our results indicate a negative effect of age, number of years since menopause and duration of disease on bone mineral density. So, BMD should be measured in high risk women prior to the implementation of any treatment or prevention program. Bangladesh Journal of Medical Science Vol. 12 No. 02 April13 Page 158-163 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14944

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The Association Between Sugar Sweetened Beverages and Bone Health Among Older Puerto Rican Adults

Current Developments in Nutrition ◽

10.1093/cdn/nzaa061_001 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1373-1373

Author(s):

Oladimeji Akinlawon ◽

Sabrina Noel ◽

Kaylea Flanagan ◽

Xiyuan Zhang ◽

Katherine Tucker

Keyword(s):

Bone Mineral Density ◽

Femoral Neck ◽

Total Energy ◽

Puerto Rican ◽

Bone Mineral ◽

Mineral Density ◽

Sugar Sweetened Beverages ◽

Sweetened Beverages ◽

Menopausal Women ◽

Post Menopausal

Abstract Objectives To assess the relationship between sugar-sweetened beverages (SSBs) and bone mineral density (BMD) in Puerto Rican adults living in Boston. Methods Data were from the Boston Puerto Rican Health Study and the Boston Puerto Rican Osteoporosis Study. SAS (version 9.4) was used to conduct general linear model analyses assessing bone mineral density as an outcome in relation to all other relevant covariates. Dietary data including sugar-sweetened beverage (SSB) intake was assessed by an FFQ that was validated for this population. We defined SSB as any sweetened drinks, including soft drinks, fruit drinks and nectars, apple juice and 100% juice blends, sweetened tea, energy drinks, coffee drinks, and Malta. Bone mineral density was determined by dual-energy x-ray absorptiometry (DXA) scan. Results The mean intake of SSB was 10.7 ± 11 ounces per day, while mean total energy was 1876 ± 843 kcal per day. A majority of the population (62.3%) were post-menopausal women. At the femoral neck, 39.7% had osteopenia and 4.4% had osteoporosis; and at the spine (L2-L4), 30.4% had osteopenia and 8% had osteoporosis. BMD of the femoral neck was significantly associated with SSB intake, and remained significantly associated across all models after adjusting for age, estrogenic status (men, pre-menopausal women or post-menopausal and using estrogen, and post-menopausal women without estrogen), population admixture, BMI, height, total energy, season of bone measurement, alcohol use, smoking status, education, physical activity score, dietary calcium, calcium supplement use, and 25(OH)D (serum) (β ± SE = −0.001 ± 0.001, P = 0.03). Other bone sites did not reach significance. Conclusions Intake of SSBs was significantly related to lower femoral neck BMD, and although not significant, was consistently negatively associated with other bone sites. Reduction in SSB intake may decrease risk of osteoporosis in this population. Funding Sources NIH.

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