Brisk Walking Reduces Calcaneal Bone Loss in Post-Menopausal Women

1997 ◽  
Vol 92 (1) ◽  
pp. 75-80 ◽  
Author(s):  
Katherine Brooke-Wavell ◽  
Peter R. M. Jones ◽  
Adrianne E. Hardman
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Femoral Neck ◽  
Bone Mineral ◽  
Brisk Walking ◽  
Mineral Density ◽  
Control Subjects ◽  
Menopausal Women ◽  
Post Menopausal

1. This study examined the influence of brisk walking on skeletal status in post-menopausal women. 2. Subjects were 84 healthy women aged 60–70 years who were previously sedentary and at least 5 years post-menopausal. Subjects were randomly assigned to walking (n = 43) and control (n = 41) groups. Walkers followed a 12-month, largely unsupervised programme of brisk walking. The bone mineral density of the lumbar spine, femoral neck and calcaneus and broadband ultrasonic attention of the calcaneus were measured at baseline and after 12 months. 3. Forty control subjects and 38 walkers completed the study. Walkers built up to 20.4 ± 3.8 min/day (mean ± SD) of brisk walking. Body mass increased in control subjects relative to walkers [mean change (SE) ± 0.9 (0.3) and −0.1 (0.3) kg respectively; P = 0.04]. Predicted maximum oxygen uptake increased in walkers by 2.1 (0.9) ml min−1 kg−1 (P = 0.02). Bone mineral density in the lumbar spine and calcaneus fell in control subjects [–0.005 (0.004) and −0.010 (0.004) g/cm2, respectively] but not in walkers [+0.006 (0.004) and +0.001 (0.004) g/cm2]. The difference in response between groups was significant in the calcaneus (P = 0.04) but not in the lumbar spine (P = 0.08). Mean femoral neck bone mineral density did not change significantly in either group, although changes in walkers were related to the amount of walking completed (r = 0.51, P = 0.001). The change in broadband ultrasonic attenuation of the calcaneus differed between groups [control subjects, −3.7 (0.8); walkers, −0.7 (0.8) dB/MHz; P = 0.01]. 4. Walking decreased bone loss in the calcaneus and possibly in the lumbar spine. It also improved functional capacity and enabled walkers to avoid the increase in body mass seen in control subjects.

Carotid plaque and lumbar bone mineral density status in post-menopausal women: An age-matched, analytical cross-sectional study

2019 ◽  
Vol 26 (1) ◽  
pp. 9-18
Author(s):  
Patraporn Sitthisombat ◽  
Sukree Soontrapa ◽  
Srinaree Kaewrudee ◽  
Jen Sothornwit ◽  
Nuntasiri Eamudomkarn ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Cardiovascular Disease ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Odds Ratio ◽  
Carotid Plaque ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Menopausal Women ◽  
Post Menopausal

Objective To explore the association between carotid plaque and lumbar spine osteoporosis in post-menopausal women. Study design Age-matched, cross-sectional study. Main outcome measures Carotid plaque and carotid intima media thickness were measured with B-mode ultrasound. Lumbar spine bone mineral density was measured with dual-energy X-ray absorptiometry. Prevalence odds ratios and the respective 95% confidence intervals (95%CI) were calculated to determine the association. Results Seventy-two post-menopausal women with lumbar spine osteoporosis and 72 post-menopausal women with normal lumbar spine bone mineral density were enrolled. The adjusted prevalence odds ratio of carotid plaque presence in post-menopausal women with lumbar spine osteoporosis was 1.73 (95%CI; 0.60 to 4.94) when compared to post-menopausal women with normal lumbar spine bone mineral density. The presence of vulnerable plaque was greater in post-menopausal women with lumbar spine osteoporosis; however, the difference was not statistically significant after adjusting for other risk factors of cardiovascular disease (odds ratio 1.31; 95%CI; 0.39 to 4.43). There was no significant difference in carotid intima media thickness between the two groups. Multiple logistic regression analysis with backward elimination in assessment of potential risk factors for the presence of carotid plaque showed that the year since menopause, family history of cardiovascular disease and systolic blood pressure were nominally significant associated factors with a respective adjusted odds ratio of 1.06 (95%CI; 1.01 to 1.12), 6.23 (95%CI; 1.65 to 23.46) and 1.03 (95%CI; 1.01 to 1.06). Conclusions The current study indicates that lumbar spine osteoporosis is not associated with the presence of carotid plaque, whereas year since menopause, family history of cardiovascular disease and systolic blood pressure are associated factors.

scholarly journals Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA

Rheumatology ◽  
2009 ◽  
Vol 49 (3) ◽  
pp. 513-519 ◽  
Author(s):  
S. P. Desai ◽  
E. M. Gravallese ◽  
N. A. Shadick ◽  
R. Glass ◽  
J. Cui ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Spine Bone Mineral Density ◽  
Mineral Density ◽  
Total Hip ◽  
Menopausal Women ◽  
Post Menopausal

scholarly journals Change in Bone Mineral Density in Post Menopausal Women with Rheumatoid Arthritis

2013 ◽  
Vol 12 (2) ◽  
pp. 158-163
Author(s):  
Mehrdad Aghaei ◽  
Sima Sedighi ◽  
Naser Behnampour ◽  
Sharabeh Hezarkhani ◽  
Mona Shirashiani ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Bone Mineral Density ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Statistical Tests ◽  
Mineral Density ◽  
Menopausal Women ◽  
Duration Of Disease ◽  
Post Menopausal

Introduction: Low bone mass is a serious complication of post menopausal women with rheumatoid arthritis. We determined the Change in Bone Mineral Density in postmenopausal women with rheumatoid arthritis. Methods: This retrospective cohort study was carried out on consecutive postmenopausal women with rheumatoid arthritis who were referred to the Azar 5th teaching hospital affiliated to Golestan University of Medical Sciences, North of Iran in 2009. The required data were gathered from the patients’ medical records. The data were analyzed using SPSS software and statistical tests. Results: We studied 98 postmenopausal women with rheumatoid arthritis. Mean number of years since menopause and mean duration of disease were 9.39 and 5.13 respectively. T Score mean in femoral neck and lumbar spines was -1.45±1.26 and -2.45±1.44 respectively. The overall prevalence of osteoporosis at both the lumbar spine and femoral neck was 13.3. We have found a significant correlation between age, duration of disease, duration of menopause and bone mineral density (P-Value<0.01). Conlusion: Our results indicate a negative effect of age, number of years since menopause and duration of disease on bone mineral density. So, BMD should be measured in high risk women prior to the implementation of any treatment or prevention program. Bangladesh Journal of Medical Science Vol. 12 No. 02 April’13 Page 158-163 DOI: http://dx.doi.org/10.3329/bjms.v12i2.14944

scholarly journals Relation Between Circulating Vitamin K1 and Osteoporosis in the Lumbar Spine in Syrian Post-Menopausal Women

2018 ◽  
Vol 12 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Sawsan Jaghsi ◽  
Taghrid Hammoud ◽  
Shaden Haddad
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Mineral ◽  
Serum Vitamin ◽  
Vitamin K1 ◽  
Mineral Density ◽  
Post Menopausal Osteoporosis ◽  
Menopausal Women ◽  
Healthy Control ◽  
Post Menopausal

Background: In the past two decades, Vitamin K has been receiving more attention due to its role in bone health and metabolism. The bone mineral density does not remain steady with age, particularly declining after menopause. Objective: This study is aimed to investigate the relationship between bone mineral density and serum vitamin K1 levels in post-menopausal women, and to evaluate serum vitamin K1 levels as a potential biomarker for postmenopausal osteoporosis. Methods: Serum levels of vitamin k1 were measured in 23 postmenopausal osteoporotic women, and in 15 postmenopausal healthy control women using a standardized Enzyme-Linked Immune Sorbent Assay (ELISA) kit. Bone mineral density BMD was assessed at the lumbar spine. Results: The mean serum vitamin k1 level was significantly lower in the postmenopausal osteoporotic women group than in the normal control group (mean=0.794 vs3.61ng/ml, P< 0.0001), and serum vitamin k1 concentration was positively correlated with lumbar spine BMD among postmenopausal osteoporotic women (R=0.533, p = 0.009), and in postmenopausal healthy control (R=0.563, p = 0.02). Diagnostic sensitivity and specificity of vitamin k1 for osteoporosis were 90% and 98%, respectively (cut-off value: 0.853 ng/ml). The area under the ROC curve (AUC) value for vitamin k1 was 0.984 the odd ratio result was 18.66. Conclusion: Our results suggest that vitamin K1 may contribute to maintain bone mineral density. Vitamin K1 may have a role in diagnosing post-menopausal osteoporosis. Vitamin K1 may be a valuable diagnostic as well as therapeutic marker in post-menopausal osteoporosis.

scholarly journals The threshold of bone mineral density for vertebral fractures in female patients with primary hyperparathyroidism

2005 ◽  
Vol 153 (3) ◽  
pp. 373-378 ◽  
Author(s):  
Hiroshi Kaji ◽  
Mika Yamauchi ◽  
Kazuo Chihara ◽  
Toshitsugu Sugimoto
Keyword(s):  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Femoral Neck ◽  
Primary Hyperparathyroidism ◽  
Bone Mineral ◽  
Vertebral Fractures ◽  
Control Group ◽  
Mineral Density ◽  
Female Patients ◽  
Control Subjects

Background and objective: Primary hyperparathyroidism (pHPT) is one of the causal diseases that induce secondary osteoporosis. Although patients with pHPT have reduced bone mineral density (BMD) especially at the cortical bone, there have been controversies about risk of fracture. Moreover, no reports have been available about the threshold of BMD for fractures in pHPT patients. Methods: BMD values were measured by dual-energy x-ray absorptiometry at lumbar spine, femoral neck and distal one third of radius. Various indices were compared in 116 female pHPT patients and 716 control subjects. Moreover, we analyzed relationship between the cut-off values of BMD and the prevalence of vertebral fractures in pHPT and control subjects. Results: The prevalence of subjects with vertebral fractures was lower in pHPT patients, compared with that of control subjects. Age and body height were significantly higher and lower in pHPT women with vertebral fractures, respectively. Lumbar spine BMD was significantly lower in pHPT women with vertebral fractures, presumably due to their increased age. There were no differences in femoral neck and radius BMD or in bone metabolic indices between pHPT women with and without vertebral fractures. On the other hand, age-matched BMD was not significantly different between both groups at any measured site. Cut-off values of BMD at lumbar spine and femoral neck were lower in postmenopausal pHPT patients, compared with those of the postmenopausal control group. Moreover, cut-off values of BMD at radius was much lower in postmenopausal pHPT patients, compared with those of the postmenopausal control group (pHPT vs control (g/cm2): 0.670 vs 0.706 at lumbar spine; 0.549 vs 0.570 at femoral; 0.394 vs 0.474 at radius). Sensitivity and specificity of vertebral fractures was lower in pHPT patients, compared with those in control group. Conclusions: The present cross-sectional study demonstrated that thresholds of BMD for vertebral fractures were lower especially at radial bone in female patients with pHPT, compared with those in the control group.

The effect of anastrozole on bone mineral density during the first 5 years of adjuvant treatment in postmenopausal women with early breast cancer.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e11604-e11604
Author(s):  
Hiroaki Inoue ◽  
Akira Hirano ◽  
Kaoru Ogura ◽  
Akinori Hattori ◽  
Mari Kamimura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Mineral Density ◽  
Lumbar Spine ◽  
Bone Loss ◽  
Adjuvant Therapy ◽  
Femoral Neck ◽  
Postmenopausal Women ◽  
Bone Mineral ◽  
Mineral Density ◽  
Alendronate Treatment

e11604 Background: Adjuvant therapy with aromatase inhibitors (AI) is associated with increased bone loss in postmenopausal women. We assessed changes in bone mineral density (BMD) from baseline to 60 months of treatment in patients receiving anastrozole (ANA) as initial adjuvant therapy with/without oral bisphosphonates (Bis). Methods: Postmenopausal women with endocrine responsive breast cancer receiving ANA as adjuvant therapy at our hospital since 2004 were enrolled in this study. BMD was assessed by dual-energy X-ray absorptiometry at baseline and after 6, 12, 24, 36, 48 and 60 months. Oral Bis (risedronate or alendronate) treatment was initiated when patients were diagnosed as having osteoporosis with a T-score of -2.5 or lower. Results: Fifty-seven patients were enrolled in the study between 2004 and 2011. Patients’ median age was 65 years (range 50~85) and the median follow-up period was 46.3 months (9.6~83.8). Thirty-five patients were administered Bis (risedronate in 27 patients, alendronate in 8 patients). Within 6 months of hormone therapy, BMD decreased by 0.3% from baseline at the lumbar spine and BMD decreased by 1.2% at the femoral neck. However, BMD increased by 2.8% at the lumbar spine and BMD decreased 0.5% at the femoral neck for 60 months of treatment. In patients treated with upfront Bis (n=24), 4.9% BMD increase from baseline was noted at the lumbar spine whereas in those without Bis (n=20) BMD decreased by 4.6% from baseline within 24 months (p=0.0002). Fractures were observed in 4 patients (7.0%), and 1 patient (1.8%) had fragility fracture. Conclusions: Oral Bis prevented ANA-induced bone loss, and upfront treatment of Bis significantly increased BMD at the lumber spine.

scholarly journals The Association Between Sugar Sweetened Beverages and Bone Health Among Older Puerto Rican Adults

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1373-1373
Author(s):  
Oladimeji Akinlawon ◽  
Sabrina Noel ◽  
Kaylea Flanagan ◽  
Xiyuan Zhang ◽  
Katherine Tucker
Keyword(s):  
Bone Mineral Density ◽  
Femoral Neck ◽  
Total Energy ◽  
Puerto Rican ◽  
Bone Mineral ◽  
Mineral Density ◽  
Sugar Sweetened Beverages ◽  
Sweetened Beverages ◽  
Menopausal Women ◽  
Post Menopausal

Abstract Objectives To assess the relationship between sugar-sweetened beverages (SSBs) and bone mineral density (BMD) in Puerto Rican adults living in Boston. Methods Data were from the Boston Puerto Rican Health Study and the Boston Puerto Rican Osteoporosis Study. SAS (version 9.4) was used to conduct general linear model analyses assessing bone mineral density as an outcome in relation to all other relevant covariates. Dietary data including sugar-sweetened beverage (SSB) intake was assessed by an FFQ that was validated for this population. We defined SSB as any sweetened drinks, including soft drinks, fruit drinks and nectars, apple juice and 100% juice blends, sweetened tea, energy drinks, coffee drinks, and Malta. Bone mineral density was determined by dual-energy x-ray absorptiometry (DXA) scan. Results The mean intake of SSB was 10.7 ± 11 ounces per day, while mean total energy was 1876 ± 843 kcal per day. A majority of the population (62.3%) were post-menopausal women. At the femoral neck, 39.7% had osteopenia and 4.4% had osteoporosis; and at the spine (L2-L4), 30.4% had osteopenia and 8% had osteoporosis. BMD of the femoral neck was significantly associated with SSB intake, and remained significantly associated across all models after adjusting for age, estrogenic status (men, pre-menopausal women or post-menopausal and using estrogen, and post-menopausal women without estrogen), population admixture, BMI, height, total energy, season of bone measurement, alcohol use, smoking status, education, physical activity score, dietary calcium, calcium supplement use, and 25(OH)D (serum) (β ± SE = −0.001 ± 0.001, P = 0.03). Other bone sites did not reach significance. Conclusions Intake of SSBs was significantly related to lower femoral neck BMD, and although not significant, was consistently negatively associated with other bone sites. Reduction in SSB intake may decrease risk of osteoporosis in this population. Funding Sources NIH.

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