Invasive cervical cancer and human immunodeficiency virus (HIV) infection: a South African perspective

2001 ◽  
Vol 11 (3) ◽  
pp. 194-197 ◽  
Author(s):  
M. Moodley ◽  
J. Moodley ◽  
I. Kleinschmidt
2006 ◽  
Vol 16 (3) ◽  
pp. 1036-1040
Author(s):  
M. Moodley

The bulk of the human immunodeficiency virus (HIV) pandemic continues to ravage the developing world, especially sub-Saharan countries. The HIV seroprevalence among women with invasive cervical cancer varies in different parts of the world. A comparison of women with cervical cancer was undertaken for epidemiologic data in the province of KwaZulu-Natal, South Africa, which has the highest HIV prevalence. The two time periods of study were 1999 and 2003. The aim was to determine the trends of prevalence of invasive cervical cancer and HIV infection among such women. While the background prevalence of HIV infection among women with invasive cervical cancer in our setting has remained constant over the two time periods (21% and 21.8%), there has been a significant reduction in the number of women presenting with invasive cervical cancer to our center (672 to 271) over the two time periods, with no changes in other variables. On the contrary, the prevalence of HIV infection among antenatal attendees had risen from 32.5% to 38.5% in the 1999 and 2003 periods, respectively. Reasons for this dramatic trend are presented together with other epidemiologic data.


2018 ◽  
Vol 8 (5-s) ◽  
pp. 394-399
Author(s):  
Subhash Kumar Mishra Golden ◽  
Nidhi Vishnoi

Background: The objective of this study was to estimate the incidence of invasive cervical cancer (ICC) in women with human immunodeficiency virus (HIV) and compare it with the incidence in HIV-uninfected women. Methods: In a cohort study of HIV-infected and uninfected women who had Papanicolaou tests obtained every 6 months, pathology reports were retrieved for women who had biopsy results or a self report of ICC. Histology was reviewed when reports confirmed ICC. Incidence rates were calculated and compared with those in HIV-negative women. Results: After a median follow-up of 10.3 years, 3 ICCs were confirmed in HIV-seropositive women, and none were confirmed in HIV-seronegative women. The ICC incidence rate was not found to be associated significantly with HIV status (HIV-negative women [0 of 100,000 person-years] vs HIV-positive women [21.4 of 100,000 person-years]; P = .59). A calculated incidence rate ratio standardized to expected results from the Surveillance Epidemiology and End Results database that was restricted to HIV-infected Women’s Interagency HIV Study participants was 1.32 (95% confidence interval, 0.27-3.85; P = 0.80). Conclusions: Among women with HIV in a prospective study that incorporated cervical cancer prevention measures, the incidence of ICC was not significantly higher than that in a comparison group of HIV-negative women. Keywords: Cervical Cancer, Human Immunodeficiency Virus, Women, Cancer Prevention.


2016 ◽  
Vol 16 (2) ◽  
pp. 26-27
Author(s):  
Anna Kornete ◽  
Elizabete Pumpure ◽  
Jana Zodzika ◽  
Dace Rezeberga ◽  
Liga Puksta-Gulbe ◽  
...  

Summary Among HIV-infected women prevalence and incidence of HPV infection are higher, and the risk for developing cervical cancer is increased. We present a case of HIV and HPV co-infection in woman with invasive cervical cancer and cervical and vaginal condyloma acuminata in association with vaginal bleeding during pregnancy.


2008 ◽  
Vol 14 (3) ◽  
pp. 352-355 ◽  
Author(s):  
Susan Louw ◽  
Barry F. Jacobson ◽  
Harry Büller

Abnormalities that predispose to a hypercoagulable state with an increased incidence of venous thrombosis have been described in human immunodeficiency virus (HIV) infections and are associated with an increased mortality. A recent systematic review by Klein et al concluded that further studies are essential to elucidate the link between HIV infection and deep vein thrombosis (DVT). We prospectively evaluated 24 consecutive, active people presenting with an acute DVT; 13 consented to HIV testing, revealing an HIV prevalence of 84% (95% confidence interval [CI], 0.65-1.04). In a matched healthy control group, the HIV prevalence was 4% (95% CI, 0.039-0.041). The high HIV prevalence in the DVT group that consented to testing was also significantly higher compared to that in the South African population, estimated to be 10% in 2005. Although the study numbers were low, a statistically significant increased prevalence of HIV infection was found in patients with acute DVTs.


2018 ◽  
Vol 17 (1) ◽  
pp. 17
Author(s):  
Adamu Abdullahi ◽  
MuhammadInuwa Mustapha ◽  
DawotolaAyorinde David ◽  
OlasindeTajudeen Ayodeji

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