Conjectures on the dynamic functional transformation of intelligent infrastructure

2006 ◽  
Vol 153 (4) ◽  
pp. 267 ◽  
Author(s):  
P. Goodwin
Keyword(s):  
Functional Transformation

Materials for Programmed, Functional Transformation in Transient Electronic Systems

2014 ◽  
Vol 27 (1) ◽  
pp. 47-52 ◽  
Author(s):  
Suk-Won Hwang ◽  
Seung-Kyun Kang ◽  
Xian Huang ◽  
Mark A. Brenckle ◽  
Fiorenzo G. Omenetto ◽  
...  
Keyword(s):  
Electronic Systems ◽  
Functional Transformation

Functional Transformation in Simplification of Multivalued Switching Functions

1972 ◽  
Vol C-21 (1) ◽  
pp. 102-105 ◽  
Author(s):  
Z.G. Vranesic ◽  
K.M. Waliuzzaman
Keyword(s):  
Functional Transformation ◽  
Switching Functions

Possibility Quantitative Appraise Components and Guidance for Constructional Rearrangement of Buildings Attached to their Confrontation

2014 ◽  
Vol 1065-1069 ◽  
pp. 2585-2588 ◽  
Author(s):  
Andrey Volkov ◽  
Vitaliy Chulkov ◽  
Ryben Kazaryan ◽  
Myhammet Fachratov ◽  
Olga Kyzina
Keyword(s):  
Functional Transformation ◽  
Special Case

Possibility quantitative components and guidance for constructional rearrangement (CR) of buildings attached to their confrontation is a special case of reorganization cycle. The main goal of CR objects is to bring them to the condition meeting the needs of users or requirements of regulatory documentation using the methods of planning and functional transformation.

scholarly journals Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment

2021 ◽  
Vol 12 ◽  
Author(s):  
Zicong He ◽  
Shuixing Zhang
Keyword(s):  
Tumor Microenvironment ◽  
Tumor Growth ◽  
Tumor Associated Macrophages ◽  
Mediate Immune Response ◽  
Functional Transformation ◽  
Functional Differences ◽  
Inflammatory Phenotype ◽  
Internal Mechanism ◽  
Hypoxic Tumor ◽  
Early Phases

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of their functional differences in tumor growth, TAMs are usually categorized into two subsets of M1 and M2. It is well established that the tumor microenvironment (TME) is characterized by hypoxia along with tumor progression. TAMs adopt an M1-like pro-inflammatory phenotype at the early phases of oncogenesis and mediate immune response that inhibits tumor growth. As tumors progress, anabatic hypoxia of the TME gradually induces the M2-like functional transformation of TAMs by means of direct effects, metabolic influence, lactic acidosis, angiogenesis, remodeled stroma, and then urges them to participate in immunosuppression, angiogenesis and other tumor-supporting procedure. Therefore, thorough comprehension of internal mechanism of this TAM functional transformation in the hypoxic TME is of the essence, and might provide some novel insights in hypoxic tumor immunotherapeutic strategies.

scholarly journals PERCEPTIONAL APPROACH IN SOCIAL-GEOGRAPHICAL RESEARCH OF THE URBAN SPACE (ON THE EXAMPLE OF LVIV)

2019 ◽  
pp. 50-56
Author(s):  
Myroslava VLAKH ◽  
Iryna HUDZELYAK
Keyword(s):  
Urban Space ◽  
Color Perception ◽  
Industrial Districts ◽  
Student Needs ◽  
Minimum Threshold ◽  
Functional Transformation ◽  
Mental Map ◽  
Unique Interpretation ◽  
The City ◽  
Coefficient Of Asymmetry

The color perception and evaluation of the attitude of the student youth towards 20 territorial parts of Lviv urban space were analyzed. The importance of the studentification for the functional transformation of urban space was emphasized. A technique developed by the Swiss psychologist M. Lusher was used to research the color perception of urban space. An electronic poll of 205 students was conducted, the results of which were analyzed in three age categories. The study found a low coefficient of asymmetry in the responses and determined a minimum threshold for a unique interpretation of the “color” of the area. A mental map of the color perception of Lviv was performed, which distinguishes areas dominated by the perception of the same color, the combination of two colors, the indistinct distribution, as well as the positive, negative and uncertain attitude of students towards them. Warm colors (yellow, green, red) were found to relate mainly to the areas of study, dwelling, and the most frequent location of the students, as well as to the desired places of residence. Black and gray colors dominate in the perception of industrial and transport-industrial districts of Lviv, which received negative opinions. The results of the study can be used in the process of adaptive transformation (according to student needs) of Lviv urban space and in specificating the paradigm of its development. In particular, according to the poll, a large part of Lviv has negative or uncertain attitude, thus its further functional transformation must take into account the needs of student youth. Colored association with territorial parts of the city may also be used for creation of verbal urbal images and formulation of relevant geospatial metaphors.

scholarly journals Integrated Analysis of Liver Transcriptome, miRNA, and Proteome of Chinese Indigenous Breed Ningxiang Pig in Three Developmental Stages Uncovers Significant miRNA–mRNA–Protein Networks in Lipid Metabolism

2021 ◽  
Vol 12 ◽  
Author(s):  
Biao Li ◽  
Jinzeng Yang ◽  
Yan Gong ◽  
Yu Xiao ◽  
Qinghua Zeng ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Expression Patterns ◽  
Immune Defense ◽  
Differentially Expressed ◽  
Integrated Analysis ◽  
Liver Development ◽  
Liver Growth ◽  
Functional Transformation ◽  
Functional Changes ◽  
Glycolipid Metabolism

Liver is an important metabolic organ of mammals. During each transitional period of life, liver metabolism is programmed by a complex molecular regulatory system for multiple physiological functions, many pathways of which are regulated by hormones and cytokines, nuclear receptors, and transcription factors. To gain a comprehensive and unbiased molecular understanding of liver growth and development in Ningxiang pigs, we analyzed the mRNA, microRNA (miRNA), and proteomes of the livers of Ningxiang pigs during lactation, nursery, and fattening periods. A total of 22,411 genes (19,653 known mRNAs and 2758 novel mRNAs), 1122 miRNAs (384 known miRNAs and 738 novel miRNAs), and 1123 unique proteins with medium and high abundance were identified by high-throughput sequencing and mass spectrometry. We show that the differences in transcriptional, post-transcriptional, or protein levels were readily identified by comparing different time periods, providing evidence that functional changes that may occur during liver development are widespread. In addition, we found many overlapping differentially expressed genes (DEGs)/differentially expressed miRNAs (DEMs)/differentially expressed proteins (DEPs) related to glycolipid metabolism in any group comparison. These overlapping DEGs/DEMs/DGPs may play an important role in functional transformation during liver development. Short Time-series Expression Miner (STEM) analysis revealed multiple expression patterns of mRNA, miRNA, and protein in the liver. Furthermore, several diverse key Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways, including immune defense, glycolipid metabolism, protein transport and uptake, and cell proliferation and development, were identified by combined analysis of DEGs and DGPs. A number of predicted miRNA–mRNA–protein pairs were found and validated by qRT-PCR and parallel reaction monitoring (PRM) assays. The results provide new and important information about the genetic breeding of Ningxiang pigs, which represents a foundation for further understanding the molecular regulatory mechanisms of dynamic development of liver tissue, functional transformation, and lipid metabolism.

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