scholarly journals Influence of supercritical CO2 flowrate in one-pot supercritical fluid extraction of Carica papaya linn. leaves: A broken-intact-cell approach

2021 ◽  
Vol 287 ◽  
pp. 02012
Author(s):  
Yee Ho Chai ◽  
Suzana Yusup ◽  
Qiu Huan Seer ◽  
Muhammad Syafiq Hazwan Ruslan ◽  
Bridgid Lai Fui Chin
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Carica Papaya ◽  
Intact Cell ◽  
Model Fitting ◽  
Fluid Extraction ◽  
Transfer Coefficients ◽  
One Pot ◽  
Extraction Curve ◽  
Fast Extraction

The presence of rich phytochemicals in Carica papaya linn. leaves are potentially beneficial in pharmaceutical, nutraceutical and food industries. This work aims to investigate the roles of solvent flowrate for the predictive behaviour of supercritical fluid extraction of essential oil-rich extracts by broken-intact-cell modelling approach. Through kinetic model fitting of experimental data, the adjustable parameters namely G, φk, Z and Y were determined through error minimization procedure. From the cumulative extraction curve at solvent rate from 4 – 8 mL/min, the values of mass transfer coefficients were in the range of 4.40 × 10−5 m2/s – 19.92 × 10−5 m2/s with an overall relative 8.67% AARD. The grinding index and end of fast extraction time period was within the range of 0.144 – 0.258 and 30.38 – 91.17 min respectively. The role of solvent flowrate played an influential role in the extraction of papaya leaves extract.

scholarly journals The Supercritical Fluid Extraction of Alkaloids from Papaya (Carica papaya L. var. Eksotika) Leaves

1970 ◽  
Vol 4 (2) ◽  
pp. 35-49 ◽  
Author(s):  
Mohamad Fhaizal Mohamad Bukhari ◽  
Noorsaadah Abdul Rahman ◽  
Norzulaani Khalid ◽  
Ahmad Hazri Rashid ◽  
Mazita Mohd Diah
Keyword(s):  
Supercritical Fluid Extraction ◽  
Supercritical Fluid ◽  
Carica Papaya ◽  
Extraction Procedure ◽  
Solvent System ◽  
Fluid Extraction ◽  
Suspension Cells ◽  
Fruit Peel ◽  
Pure Compounds

Since the isolation procedures are easy, many of the earliest pure compounds isolated with biological activitywere alkaloids. The nitrogen molecules in plant cells generally make the compound alkaline which makealkaloids exist in a salt form in plants. Thus, alkaloids are often extracted with water and/or acid solution systemand then recovered as crystalline material by treatment using a base. The alkaloid carpaine was extracted fromvarious part of Carica papaya L. var. Eksotika from field grown samples namely leaves, petiole and fruit peel,and from in vitro samples namely leaves, petiole, suspension cells and suspension liquid with only one artifact ofimpurity detected i.e. dehydrocarpaine II. Supercritical fluid extraction was analysed to obtain pure and highyield of carpaine compound as compared to conventional acid base extraction method. The ratio ofethanol/water/acetic acid used at 94.5:5:0.5 (v/v/v) was confirmed to be a better solvent system for carpaineextraction since only one pseudocarpaine i.e. dehydrocarpaine II was extracted together with carpaine. In thisstudy, the application of single fluid of carbon dioxide in supercritical fluid extraction procedure generated pureand higher yield of carpaine compound. Additional centrifugation step should have contributed to a higher purityof the extracted carpaine.

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