Management of undifferentiated thyroid cancer

2000 ◽  
Vol 14 (4) ◽  
pp. 615-629 ◽  
Author(s):  
Kenneth B Ain

2002 ◽  
Vol 80 (4) ◽  
pp. 197-203 ◽  
Author(s):  
Kana Ogisawa ◽  
Naoyoshi Onoda ◽  
Tetsuro Ishikawa ◽  
Chiemi Takenaka ◽  
Masaaki Inaba ◽  
...  


1994 ◽  
pp. 295-297
Author(s):  
F. Kober ◽  
A. Heiss ◽  
B. Neugebauer ◽  
R. Roka


Endocrine ◽  
2016 ◽  
Vol 56 (2) ◽  
pp. 388-398
Author(s):  
Elisa Stellaria Grassi ◽  
Alessandra Dicitore ◽  
Irene Negri ◽  
Maria Orietta Borghi ◽  
Giovanni Vitale ◽  
...  


2012 ◽  
Vol 29 (7) ◽  
pp. 1990-2005 ◽  
Author(s):  
Shih-Che Hua ◽  
Tien-Chun Chang ◽  
Hau-Ren Chen ◽  
Chieh-Hsiang Lu ◽  
Yi-Wen Liu ◽  
...  


2007 ◽  
Vol 69 (4) ◽  
pp. 1059-1066 ◽  
Author(s):  
Maria Alejandra Dagrosa ◽  
Lisa Thomasz ◽  
Juan Longhino ◽  
Marina Perona ◽  
Osvaldo Calzetta ◽  
...  


2018 ◽  
Author(s):  
Raquel Miralles Moragrega ◽  
Maria Maria Curras Freixes ◽  
Carolina Perdomo Zelaya ◽  
Javier Gargallo Vaamonde ◽  
Maria Llavero Valero ◽  
...  


Neoplasia ◽  
2014 ◽  
Vol 16 (9) ◽  
pp. 757-769 ◽  
Author(s):  
Xuguang Zhu ◽  
Li Zhao ◽  
Jeong Won Park ◽  
Mark C. Willingham ◽  
Sheue-yann Cheng


2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
V. V. Pushkarev ◽  
O. I. Kovzun ◽  
V. M. Pushkarev ◽  
M. D. Tronko

Aim. To study the significance of cyclin-dependent kinases (Cdks) in paclitaxel-dependent apoptosis in colon and undifferentiated thyroid cancer cells. Materials and Methods. Experiments were performed on undifferentiated thyroid carcinoma (KTC-2) and colon carcinoma (ARO) cell lines. Cells were treated with paclitaxel (Ptx) and inhibitor of Cdk, roscovitine. Cell survival test and Western blotting were used for characterization of the effects of paclitaxel and roscovitine on cancer cells. Results. It was shown that not c-Jun N-terminal kinase, but cyclin-dependent kinases are responsible for antiapoptotic Bcl-2 phosphorylation. Cdk inhibition enhanced the cytotoxic effects of Ptx at low drug concentrations. There was antagonism between Ptx and roscovitine at higher (25 nM) paclitaxel concentrations. Conclusion. Using of paclitaxel at low (2.5 to 5 nM) concentrations and roscovitine is a promising combination for further preclinical trials for the development of new therapeutic approaches to the treatment of colon and anaplastic thyroid cancer.



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