Holding Water: Congenital Anomalies of the Kidney and Urinary Tract, CKD, and the Ongoing Role of Excellence in Plumbing

2017 ◽  
Vol 24 (6) ◽  
pp. 357-363 ◽  
Author(s):  
Lars J. Cisek
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies

scholarly journals Congenital Anomalies of the Kidney and Urinary Tract: A Genetic Disorder?

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Ihor V. Yosypiv
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Genetic Disorder ◽  
Single Gene ◽  
Mouse Mutants ◽  
Gene Defects ◽  
End Stage ◽  
Genetic Contributions ◽  
New Strategies

Congenital anomalies of the kidney and urinary tract (CAKUTs) occur in 3–6 per 1000 live births, account for the most cases of pediatric end-stage kidney disease (ESKD), and predispose an individual to hypertension and cardiovascular disease throughout life. Although CAKUTs are a part of many known syndromes, only few single-candidate causative genes have been implicated so far in nonsyndromic cases of human CAKUT. Evidence from mouse models supports the hypothesis that non-syndromic human CAKUT may be caused by single-gene defects. Because increasing numbers of children with CAKUT are surviving to adulthood, better understanding of the molecular pathogenesis of CAKUT, development of new strategies aiming at prevention of CAKUT, preservation of renal function, and avoidance of associated cardiovascular morbidity are needed. In this paper, we will focus on the knowledge derived from the study of syndromic and non-syndromic forms of CAKUT in humans and mouse mutants to discuss the role of genetic, epigenetic, andin uteroenvironmental factors in the pathogenesis of non-syndromic forms of CAKUT in children with particular emphasis on the genetic contributions to CAKUT.

scholarly journals Role of biomechanical forces in hyperfiltration-mediated glomerular injury in congenital anomalies of the kidney and urinary tract

2017 ◽  
Vol 32 (5) ◽  
pp. 759-765 ◽  
Author(s):  
Tarak Srivastava ◽  
Ganesh Thiagarajan ◽  
Uri S. Alon ◽  
Ram Sharma ◽  
Ashraf El-Meanawy ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Glomerular Injury ◽  
Biomechanical Forces

scholarly journals Role of the Angiotensin Type 2 Receptor Gene in Congenital Anomalies of the Kidney and Urinary Tract, CAKUT, of Mice and Men

1999 ◽  
Vol 3 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Hideki Nishimura ◽  
Elizabeth Yerkes ◽  
Katharina Hohenfellner ◽  
Yoichi Miyazaki ◽  
Ji Ma ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Receptor Gene ◽  
Angiotensin Type 2 Receptor ◽  
Of Mice And Men ◽  
Angiotensin Type

CONGENITAL ANOMALIES OF THE KIDNEY AND URINARY TRACT— ROLE OF THE LOSS OF FUNCTION MUTATION IN THE PLURIPOTENT ANGIOTENSIN TYPE 2 RECEPTOR GENE

2001 ◽  
Vol 165 (1) ◽  
pp. 196-202 ◽  
Author(s):  
JOHN C. POPE ◽  
JOHN W. BROCK ◽  
MARK C. ADAMS ◽  
YOICHI MIYAZAKI ◽  
F. DOUGLAS STEPHENS ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies ◽  
Receptor Gene ◽  
Loss Of Function ◽  
Angiotensin Type 2 Receptor ◽  
Angiotensin Type

scholarly journals Role of angiotensin in the congenital anomalies of the kidney and urinary tract in the mouse and the human

1998 ◽  
Vol 54 ◽  
pp. S75-S77 ◽  
Author(s):  
Elizabeth Yerkes ◽  
Hideki Nishimura ◽  
Youichi Miyazaki ◽  
Shinya Tsuchida ◽  
John W. Brock ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Congenital Anomalies

Vitamin A: dietologist’s position

2020 ◽  
pp. 49-57
Author(s):  
S. V. Orlova ◽  
E. A. Nikitina ◽  
L. I. Karushina ◽  
Yu. A. Pigaryova ◽  
O. E. Pronina
Keyword(s):  
Immune Response ◽  
Urinary Tract ◽  
Gastrointestinal Tract ◽  
Vitamin A ◽  
Developed Countries ◽  
Therapeutic Practice ◽  
The Past ◽  
Increased Risk ◽  
Mucous Membranes

Vitamin A (retinol) is one of the key elements for regulating the immune response and controls the division and differentiation of epithelial cells of the mucous membranes of the bronchopulmonary system, gastrointestinal tract, urinary tract, eyes, etc. Its significance in the context of the COVID‑19 pandemic is difficult to overestimate. However, a number of studies conducted in the past have associated the additional intake of vitamin A with an increased risk of developing cancer, as a result of which vitamin A was practically excluded from therapeutic practice in developed countries. Our review highlights the role of vitamin A in maintaining human health and the latest data on its effect on the development mechanisms of somatic pathology.

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