Kognitiontest können früh auf Depression hinweisen

2018 ◽  
Vol 86 (08) ◽  
pp. 460-461
Keyword(s):  
Major Depression ◽  
First Episode

Bei einer Major Depression lassen sich in vielen kognitiven Domänen Dysfunktionen nachweisen. Ob solche Defizite auch bei einer ersten Episode einer unipolaren Depression (first episode depression, FED) nachweisbar sind und wie sie sich im weiteren Verlauf entwickeln, prüften Muriel Vicent-Gil von der psychiatrischen Abteilung des Hospitals de la Santa Creu i Sant Pau in Barcelona und ihre Kollegen aus ganz Spanien.

Neurocircuitries of Emotion Processing Affected in Major Depressive Disorder

2019 ◽  
pp. 101-114
Author(s):  
Anjali Sankar ◽  
Cynthia H.Y. Fu
Keyword(s):  
Major Depression ◽  
Predictive Accuracy ◽  
Emotion Processing ◽  
Affective State ◽  
Brain Regions ◽  
First Episode ◽  
Neuroimaging Data ◽  
Multivariate Pattern ◽  
Future Work ◽  
Hallmark Feature

Impairments in processing emotions are a hallmark feature of depression. Advances in neuroimaging techniques have rapidly improved our understanding of the pathophysiology underlying major depression. In this chapter, we provide an overview of influential neural models of emotion perception and regulation and discuss the neurocircuitries of emotion processing that are affected. Major depression is characterized by impairments in widespread brain regions that are evident in the first episode. Models have sought to distinguish the neural circuitry associated with recognition of the emotion, integration of somatic responses, and monitoring of the affective state. In particular, there has been a preponderance of research on the neurocircuitries affected during processing of mood-congruent negative emotional stimuli in depression. While neuroimaging correlates have been investigated and models proposed, these findings have had limited clinical applicability to date. Novel methods such as multivariate pattern recognition applied to neuroimaging data might enable identification of reliable, valid, and robust biomarkers with high predictive accuracy that can be applied to an individual. Last, we discuss avenues for extension and future work.

Adverse Childhood Experiences and Risk for First-Episode Major Depression During the Menopause Transition

2017 ◽  
Vol 78 (3) ◽  
pp. e298-e307 ◽  
Author(s):  
C. Neill Epperson ◽  
Mary D. Sammel ◽  
Tracy L. Bale ◽  
Deborah R. Kim ◽  
Sarah Conlin ◽  
...  
Keyword(s):  
Major Depression ◽  
Adverse Childhood Experiences ◽  
First Episode ◽  
Childhood Experiences ◽  
Adverse Childhood ◽  
Menopause Transition

scholarly journals Neural basis of recollection in first-episode major depression

2012 ◽  
Vol 34 (2) ◽  
pp. 283-294 ◽  
Author(s):  
Philip van Eijndhoven ◽  
Guido van Wingen ◽  
Guillén Fernández ◽  
Mark Rijpkema ◽  
Monica Pop-Purceleanu ◽  
...  
Keyword(s):  
Major Depression ◽  
First Episode ◽  
Neural Basis

scholarly journals Association of Serum Kynurenine Levels and Neural Networks in Patients with First-Episode, Drug-Naïve Major Depression: A Source-Based Morphometry Study

2020 ◽  
Vol Volume 16 ◽  
pp. 2569-2577
Author(s):  
Naomichi Okamoto ◽  
Keita Watanabe ◽  
LeHoa Nguyen ◽  
Atsuko Ikenouchi ◽  
Taro Kishi ◽  
...  
Keyword(s):  
Neural Networks ◽  
Major Depression ◽  
First Episode ◽  
Drug Naïve

scholarly journals Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients

2016 ◽  
Vol 176 (2-3) ◽  
pp. 417-422 ◽  
Author(s):  
M. Heslin ◽  
J.M. Lappin ◽  
K. Donoghue ◽  
B. Lomas ◽  
U. Reininghaus ◽  
...  
Keyword(s):  
Major Depression ◽  
First Episode ◽  
Psychotic Major Depression ◽  
Bipolar Patients

Psychoendocrine antecedents of persistent first-episode major depression in adolescents: a community-based longitudinal enquiry

2003 ◽  
Vol 33 (4) ◽  
pp. 601-610 ◽  
Author(s):  
I. M. GOODYER ◽  
J. HERBERT ◽  
A. TAMPLIN
Keyword(s):  
High Risk ◽  
Major Depression ◽  
Life Events ◽  
First Episode ◽  
Community Based ◽  
Morning Cortisol ◽  
Regression Techniques ◽  
Dsm Iv ◽  
Endocrine Features

Background. This longitudinal study investigated whether patterns of cortisol and DHEA that precede the onset of an episode of major depression influence time to recovery in a community ascertained sample of adolescents meeting DSM-IV criteria for major depression.Method. Sixty adolescents aged 12 to 16 at high risk for psychiatric disorders were followed for 24 months. At 12 months, 30 had experienced an episode of major depression and 30 had not. The second follow-up repeated the psychiatric evaluations with all participants completing the Kiddie-SADS Schedule for Schizophrenia and Affective Disorders. Hormone characteristics and self-reports completed at entry (the Mood and Feelings questionnaire and the Ruminations scale) together with intervening undesirable life events in the 12 months prior to onset, were used to determine the best pattern of psychosocial and endocrine features to predict persistent major depression.Results. Compared to the never depressed (N=30) and remitted adolescents (N=19), persistently depressed cases (N=11) had a raised morning cortisol/DHEA ratio at entry. Only persistent cases had higher levels of self-reported depressive symptoms and ruminations at entry compared to never depressed. There was no difference in exposure to undesirable life events before onset of disorder between remitted and persistent groups. Logistic regression techniques showed that only the cortisol/DHEA ratio predicted persistence.Conclusions. In community adolescents at high risk for psychiatric disorder persistent major depression may be distinguished from sporadic forms by the 08.00 h salivary cortisol/DHEA ratio prior to onset.

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