scholarly journals Ten-year outcomes in first episode psychotic major depression patients compared with schizophrenia and bipolar patients

2016 ◽  
Vol 176 (2-3) ◽  
pp. 417-422 ◽  
Author(s):  
M. Heslin ◽  
J.M. Lappin ◽  
K. Donoghue ◽  
B. Lomas ◽  
U. Reininghaus ◽  
...  
Keyword(s):  
Major Depression ◽  
First Episode ◽  
Psychotic Major Depression ◽  
Bipolar Patients

Kognitiontest können früh auf Depression hinweisen

2018 ◽  
Vol 86 (08) ◽  
pp. 460-461
Keyword(s):  
Major Depression ◽  
First Episode

Bei einer Major Depression lassen sich in vielen kognitiven Domänen Dysfunktionen nachweisen. Ob solche Defizite auch bei einer ersten Episode einer unipolaren Depression (first episode depression, FED) nachweisbar sind und wie sie sich im weiteren Verlauf entwickeln, prüften Muriel Vicent-Gil von der psychiatrischen Abteilung des Hospitals de la Santa Creu i Sant Pau in Barcelona und ihre Kollegen aus ganz Spanien.

scholarly journals Clinical characteristics and sociodemographic features of psychotic major depression

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Meng-qi Wang ◽  
Ran-ran Wang ◽  
Yu Hao ◽  
Wei-feng Xiong ◽  
Ling Han ◽  
...  
Keyword(s):  
Family History ◽  
Major Depression ◽  
Clinical Characteristics ◽  
Missing Values ◽  
Psychotic Disorders ◽  
Mental Health Center ◽  
Psychiatric Diseases ◽  
First Onset ◽  
History Of ◽  
Psychotic Major Depression

Abstract Background Psychotic major depression (PMD) is a subtype of depression with a poor prognosis. Previous studies have failed to find many differences between patients with PMD and those with non-psychotic major depression (NMD) or schizophrenia (SZ). We compared sociodemographic factors (including season of conception) and clinical characteristics between patients with PMD, NMD, and schizophrenia. Our aim was to provide data to help inform clinical diagnoses and future etiology research. Methods This study used data of all patients admitted to Shandong Mental Health Center from June 1, 2016 to December 31, 2017. We analyzed cases who had experienced an episode of PMD (International Classification of Diseases, Tenth Revision codes F32.3, F33.3), NMD (F32.0–2/9, F33.0–2/9), and SZ (F20–20.9). Data on sex, main discharge diagnosis, date of birth, ethnicity, family history of psychiatric diseases, marital status, age at first onset, education, allergy history, and presence of trigger events were collected. Odds ratios (OR) were calculated using logistic regression analyses. Missing values were filled using the k-nearest neighbor method. Results PMD patients were more likely to have a family history of psychiatric diseases in their first-, second-, and third-degree relatives ([OR] 1.701, 95% confidence interval [CI] 1.019–2.804) and to have obtained a higher level of education (OR 1.451, 95% CI 1.168–1.808) compared with depression patients without psychotic features. Compared to PMD patients, schizophrenia patients had lower education (OR 0.604, 95% CI 0.492–0.741), were more often divorced (OR 3.087, 95% CI 1.168–10.096), had a younger age of onset (OR 0.934, 95% CI 0.914–0.954), less likely to have a history of allergies (OR 0.604, 95% CI 0.492–0.741), and less likely to have experienced a trigger event 1 year before first onset (OR 0.420, 95% CI 0.267–0.661). Season of conception, ethnicity, and sex did not differ significantly between PMD and NMD or schizophrenia and PMD. Conclusions PMD patients have more similarities with NMD patients than SZ patients in terms of demographic and clinical characteristics. The differences found between PMD and SZ, and PMD and NMD correlated with specificity of the diseases. Furthermore, allergy history should be considered in future epidemiological studies of psychotic disorders.

scholarly journals Antidepressant and antipsychotic treatment of Psychotic Major Depression in a British mental healthcare setting

2021 ◽  
pp. 1-7
Author(s):  
Eshim S. Jami ◽  
Megan Pritchard ◽  
Hitesh Shetty ◽  
Robert Stewart ◽  
Allan H. Young ◽  
...  
Keyword(s):  
Major Depression ◽  
Mental Healthcare ◽  
Healthcare Setting ◽  
Antipsychotic Treatment ◽  
Psychotic Major Depression

Baseline and prodromal characteristics of first- versus multiple-episode mania in a French cohort of bipolar patients

2011 ◽  
Vol 27 (8) ◽  
pp. 557-562 ◽  
Author(s):  
J.-M. Azorin ◽  
A. Kaladjian ◽  
M. Adida ◽  
E. Fakra ◽  
E. Hantouche ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicide Attempts ◽  
Correct Diagnosis ◽  
Manic Episode ◽  
Psychotic Symptoms ◽  
First Episode ◽  
Prodromal Phase ◽  
Multiple Episode ◽  
Patients At Risk ◽  
Bipolar Patients

AbstractObjective:To identify some of the main features of bipolar disorder for both first-episode (FE) mania and the preceding prodromal phase, in order to increase earlier recognition.Methods:One thousand and ninety manic patients (FE=81, multiple-episodes [ME]=1009) were assessed for clinical and temperamental characteristics.Results:Compared to ME, FE patients reported more psychotic and less depressive symptoms but were comparable with respect to temperamental measures and comorbid anxiety. The following independent variables were associated with FE mania: a shorter delay before correct diagnosis, greater substance use, being not divorced, greater stressors before current mania, a prior diagnosis of an anxiety disorder, lower levels of depression during index manic episode, and more suicide attempts in the past year.Conclusion:In FE patients, the diagnosis of mania may be overlooked, as they present with more psychotic symptoms than ME patients. The prodromal phase is characterised by high levels of stress, suicide attempts, anxiety disorders and alcohol or substance abuse. Data suggest to consider these prodromes as harmful consequences of temperamental predispositions to bipolar disorder that may concur to precipitate mania onset. Their occurrence should therefore incite clinicians to screen for the presence of such predispositions, in order to identify patients at risk of FE mania.

Neurocircuitries of Emotion Processing Affected in Major Depressive Disorder

2019 ◽  
pp. 101-114
Author(s):  
Anjali Sankar ◽  
Cynthia H.Y. Fu
Keyword(s):  
Major Depression ◽  
Predictive Accuracy ◽  
Emotion Processing ◽  
Affective State ◽  
Brain Regions ◽  
First Episode ◽  
Neuroimaging Data ◽  
Multivariate Pattern ◽  
Future Work ◽  
Hallmark Feature

Impairments in processing emotions are a hallmark feature of depression. Advances in neuroimaging techniques have rapidly improved our understanding of the pathophysiology underlying major depression. In this chapter, we provide an overview of influential neural models of emotion perception and regulation and discuss the neurocircuitries of emotion processing that are affected. Major depression is characterized by impairments in widespread brain regions that are evident in the first episode. Models have sought to distinguish the neural circuitry associated with recognition of the emotion, integration of somatic responses, and monitoring of the affective state. In particular, there has been a preponderance of research on the neurocircuitries affected during processing of mood-congruent negative emotional stimuli in depression. While neuroimaging correlates have been investigated and models proposed, these findings have had limited clinical applicability to date. Novel methods such as multivariate pattern recognition applied to neuroimaging data might enable identification of reliable, valid, and robust biomarkers with high predictive accuracy that can be applied to an individual. Last, we discuss avenues for extension and future work.

Novel Strategies in the Treatment of Psychotic Major Depression

2002 ◽  
Vol 32 (11) ◽  
pp. 695-698
Author(s):  
Charles DeBattista ◽  
Joseph Belanoff
Keyword(s):  
Major Depression ◽  
Psychotic Major Depression
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