Synthesis of Spirocyclic Piperidines by Radical Hydroarylation
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AbstractReported here are conditions for the construction of spirocyclic piperidines from linear aryl halide precursors. These conditions employ a strongly reducing organic photoredox catalyst in combination with a trialkylamine reductant to achieve formation of aryl radical species. Regioselective cyclization followed by hydrogen-atom transfer affords a range of complex spiropiperidines. This system operates efficiently under mild conditions without the need for toxic reagents or precious metals.
2001 ◽
Vol 4
(6)
◽
pp. 439-442
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2019 ◽
2020 ◽
2019 ◽
2019 ◽
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