A testudinid herpesvirus 1 (TeHV1)-associated disease outbreak in a group of Horsfield’s tortoises (Testudo horsfieldii)

2021 ◽  
Vol 49 (06) ◽  
pp. 462-467
Author(s):  
Lisa Schüler ◽  
Pierre Picquet ◽  
Christoph Leineweber ◽  
Janosch Dietz ◽  
Elisabeth Müller ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Histological Examination ◽  
Inclusion Bodies ◽  
Severe Disease ◽  
Disease Outbreak ◽  
High Morbidity ◽  
Intranuclear Inclusion ◽  
Upper Respiratory ◽  
Herpesvirus 1 ◽  
Mycoplasma Spp

AbstractIn spring 2020, a severe disease outbreak with high morbidity and mortality was observed in a collection of 15 Horsfield’s tortoises (Testudo horsfieldii). Affected tortoises showed upper respiratory- and gastrointestinal tract signs, including rhinitis and stomatitis. Testudinid herpesvirus 1 (TeHV1) and Mycoplasma spp. were detected by PCR in oral swabs of affected animals. Histological examination of one deceased animal showed intranuclear inclusion bodies typical for herpesvirus infections in liver, spleen and oesophagus. The virus was likely introduced into the collection 2 years earlier by a clinically healthy Horsfield’s tortoise that was tested positive for TeHV1 by PCR.

scholarly journals An Outbreak of Adenoviral Infection in Inland Bearded Dragons (Pogona Vitticeps) Coinfected with Dependovirus and Coccidial Protozoa (Isospora Sp.)

2002 ◽  
Vol 14 (4) ◽  
pp. 332-334 ◽  
Author(s):  
Dae Young Kim ◽  
Mark A. Mitchell ◽  
Rudy W. Bauer ◽  
Rob Poston ◽  
Doo-Youn Cho
Keyword(s):  
Inclusion Bodies ◽  
Critical Role ◽  
Clinical Signs ◽  
Head Tilt ◽  
High Morbidity ◽  
Intranuclear Inclusion ◽  
Adenoviral Infection ◽  
Transmission Electron ◽  
Short Period ◽  
20 Nm

Thirty of 200 (15%) hatchling inland bearded dragons were found dead after a short period (48 hours) of weakness and lethargy. The most common clinical signs were head tilt and circling. Six bearded dragons with neurological signs were euthanized, and postmortem examination revealed no gross abnormalities. Microscopically, severe, randomly distributed hepatocellular necrosis with large basophilic intranuclear inclusion bodies in numerous hepatocytes was noted. Small-intestinal enterocytes contained intracytoplasmic coccidial protozoa ( Isospora sp.) and occasional enterocytes had basophilic intranuclear inclusion bodies. Transmission electron microscopy revealed both 80- and 20-nm-diameter viral particles, which were consistent with adenoviruses and dependoviruses, respectively. Adenoviral outbreaks in groups of animals are uncommon. An adverse synergistic effect of the coccidiosis with the adenoviral infection may have played a critical role in the high morbidity and mortality in this case.

Infectious laryngotracheitis of chickens: Pathologic and immunohistochemistry findings

2021 ◽  
pp. 030098582110353
Author(s):  
Silvia Carnaccini ◽  
Chiara Palmieri ◽  
Simone Stoute ◽  
Manuela Crispo ◽  
H. L. Shivaprasad
Keyword(s):  
Respiratory Tract ◽  
Inclusion Bodies ◽  
Viral Antigen ◽  
Intranuclear Inclusion ◽  
Test Sensitivity ◽  
Infectious Laryngotracheitis ◽  
Macroscopic Findings ◽  
Upper Respiratory ◽  
Backyard Flocks ◽  
Formalin Fixed

Infectious laryngotracheitis (ILT) is an important upper respiratory disease of chickens. Gross and histologic lesions of ILT in chickens are compared to immunohistochemistry to evaluate the diagnostic test sensitivity. A total of 31 separate ILT-confirmed necropsy submissions (12 commercial meat-type flocks, 13 egg-type producers, and 6 backyard flocks) were arbitrarily selected. Each submission ranged from 1 to 18 birds, for a total of 246 chickens. Cases with available formalin-fixed tissues were selected to include a range of bird production types, ages, clinical histories, and severity of macroscopic and histologic lesions. Macroscopic findings in the respiratory tract varied from increased mucus (55.6%) to fibrinonecrotic exudate (20.3%) and hemorrhages in the larynx and trachea (13.0%). Syncytia with intranuclear inclusion bodies were present in the respiratory tract epithelium with or without hemorrhages. Sections of conjunctiva, sinus, larynx, trachea, lung, and air sac were analyzed by immunohistochemistry (IHC) to detect gallid alphaherpesvirus 1 (GaHV-1) antigen. Positive immunolabeling was detected in the cytoplasm and nuclei of syncytia and epithelial cells in 18/22 conjunctivae (82%), 12/13 sinuses (92%), 18/22 larynxes (82%), 23/25 tracheas (92%), 10/21 lungs (57%), and 3/8 air sacs (37%). Of the 34 tissues with no visible syncytia or inclusion bodies, 8 were positive by IHC. In conclusion, IHC was useful to study the viral antigen tissue distribution and support the diagnosis of ILT when the histopathologic interpretation was doubtful.

Meningoencephalomyelitis in Horses Associated with Equine Herpesvirus 1 Infection

1976 ◽  
Vol 13 (1) ◽  
pp. 59-68 ◽  
Author(s):  
K. M. Charltons ◽  
D. Mitchell ◽  
A. Girard ◽  
A. H. Corner
Keyword(s):  
Spinal Cord ◽  
White Matter ◽  
Inclusion Bodies ◽  
Neurologic Disease ◽  
Equine Herpesvirus ◽  
Intranuclear Inclusion ◽  
Equine Herpesvirus 1 ◽  
Thyroid Adenomas ◽  
Herpesvirus 1 ◽  
Brain And Spinal Cord

During an outbreak of abortion caused by equine herpesvirus 1, a neurologic disease characterized clinically by dullness and ataxia occurred in several mares. Equine herpesvirus 1 was isolated from brain and lung of two severely affected mares. Histologically, both mares had disseminated meningoencephalomyelitis characterized by necrotizing arteritis, focal malacia in grey and white matter of brain and spinal cord, and accumulation of lymphocytes and neutrophils in paravertebral ganglia. Eosinophilic intranuclear inclusion bodies occurred in foci of necrosis in thyroid adenomas of both mares.

Glial intranuclear inclusion bodies in a patient with Alzheimer's disease

2000 ◽  
Vol 99 (6) ◽  
pp. 695-698 ◽  
Author(s):  
J. Al-Maghrabi ◽  
M. Tierney ◽  
L. C. Ang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Inclusion Bodies ◽  
Intranuclear Inclusion

scholarly journals Cytomegalovirus infection in a pig in South Africa

2002 ◽  
Vol 73 (1) ◽  
Author(s):  
M.G. Collett ◽  
D.C. Roberts
Keyword(s):  
South Africa ◽  
Inclusion Bodies ◽  
Cytomegalovirus Infection ◽  
Mouth Breathing ◽  
Nasal Discharge ◽  
Intranuclear Inclusion ◽  
Porcine Cytomegalovirus ◽  
Histological Evidence

An 8-week-old piglet with dyspnoea, bilateral mucopurulent nasal discharge and mouth breathing was euthanased and a necropsy was performed. Apart from histological evidence of diffuse rhinitis, large intranuclear inclusion bodies, pathognomonic for porcine cytomegalovirus infection, were detected within mucous glands on the nasal turbinates. This is the first such case to be diagnosed in South Africa.

Rituximab as pre-emptive treatment in patients with thrombotic thrombocytopenic purpura and evidence of anti-ADAMTS13 autoantibodies

2009 ◽  
Vol 101 (02) ◽  
pp. 233-238 ◽  
Author(s):  
Sara Gastoldi ◽  
Erica Daina ◽  
Daniela Belotti ◽  
Enrico Pogliani ◽  
Paolo Perseghin ◽  
...  
Keyword(s):  
Thrombotic Thrombocytopenic Purpura ◽  
Therapeutic Option ◽  
Severe Disease ◽  
Renal Involvement ◽  
First Episode ◽  
High Morbidity ◽  
Sustained Remission ◽  
Adamts13 Activity ◽  
Thrombocytopenic Purpura ◽  
Haemolytic Anemia

SummaryThrombotic thrombocytopenic purpura (TTP) is a rare and severe disease characterized by thrombocytopenia, microangiopathic haemolytic anemia, neurological and renal involvement associated with deficiency of the von Willebrand factor-cleaving protease, ADAMTS13. Persistence of high titers of anti-ADAMTS13 autoantibodies predisposes to relapsing TTP. Since relapses are associated with high morbidity and mortality rates, the optimal therapeutic option should be a pre-emptive treatment able to deplete anti-ADAMTS13 autoantibodies and avoid relapses. Five patients who presented with persistence of undetectable ADAMTS13 activity and high titers of autoantibodies, were treated with rituximab as pre-emptive therapy during remission. Four of them were affected by relapsing TTP and one was treated after the first episode. ADAMTS13 activity ranging from 15% to 75% with disappearance of inhibitors was achieved after three months in all patients, and persisted >20% without inhibitors at six months. In three patients disease-free status is still ongoing after 29, 24 and six months, respectively. Relapses were documented in two patients during follow-up: in one patient remission lasted 51 months; while in the other patient relapse occurred after 13 months. Results demonstrated that rituximab used as pre-emptive treatment may be effective in maintaining a sustained remission in patients with anti-ADAMTS13 antibodies in whom other treatments failed to limit the production of inhibitors, and suggests that re-treatment with rituximab should be considered when ADAMTS13 activity decreases and inhibitors reappear into the circulation, to avoid a new relapse.

Idiopathic intranuclear inclusion bodies in the renal epithelium of macropods

1997 ◽  
Vol 75 (6) ◽  
pp. 446-447
Author(s):  
R. SPEARE ◽  
JA DONOVAN ◽  
LF SKERRATT ◽  
L. BERGER ◽  
PW LADDS ◽  
...  
Keyword(s):  
Inclusion Bodies ◽  
Intranuclear Inclusion ◽  
Renal Epithelium

scholarly journals Coronavirus infection and gut microbiota

2021 ◽  
Vol 102 (4) ◽  
pp. 518-527
Author(s):  
D D Safina ◽  
S R Abdulkhakov
Keyword(s):  
Gastrointestinal Tract ◽  
Gut Microbiota ◽  
Viral Infections ◽  
Subsequent Development ◽  
Upper Respiratory Tract ◽  
Therapeutic Approaches ◽  
Coronavirus Infection ◽  
Upper Respiratory ◽  
Treatment Of Infection ◽  
Tract Disorder

At present time, a number of questions regarding the pathophysiological characteristics and therapeutic approaches to the treatment of the new coronavirus infection COVID-19 remain unresolved. In some cases, patients with COVID-19 may experience symptoms of gastrointestinal tract disorder. According to the literature, the new SARS-CoV-2 coronavirus can replicate in the gastrointestinal tract and may affect the gut microbiota. The article aims to review studies about the possible relationship between the gut microbiota condition and the course of COVID-19 infection, as well as to consider the gut microbiota as a potential therapeutic target and probiotic drugs as possible therapeutic agents in the treatment of viral infections, including COVID-19 infection. It is known that gut microbiota condition is one of the factors determining the susceptibility and features of the bodys response to various infectious agents, possibly including the COVID-19 infection. Currently published studies demonstrate a possible relationship between the gut microbiota condition and the course of COVID-19 infection, however, to confirm this hypothesis, additional studies are required, which will allow to make more unambiguous conclusions with subsequent development of new approaches to the prevention and treatment of infection. Potentially a lot of hope in this direction is inspired by the results of probiotics studies, which showed that their use may reduce the frequency and severity of viral infections of the upper respiratory tract. However, currently, there is insufficient data to extrapolate the results of these studies to COVID-19 patients.

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