CHAPTER 26 Radionuclide Lymphoscintigraphy

Lymphedema ◽  
2016 ◽  
Keyword(s):  
Radionuclide Lymphoscintigraphy

Current Evaluation of Lymphoedema and Assessment by Lymphoscintigraphy of the Effect of a Micronized Flavonoid Fraction (Daflon 500 mg) in the Treatment of Upper Limb Lymphoedema

1994 ◽  
Vol 9 (1_suppl) ◽  
pp. 26-29 ◽  
Author(s):  
A. P. Pecking ◽  
P. Rambert
Keyword(s):  
Breast Cancer ◽  
Upper Limb ◽  
Previous Treatment ◽  
University Hospital ◽  
Limb Volume ◽  
Flavonoid Fraction ◽  
Radionuclide Lymphoscintigraphy ◽  
Hospital Outpatients ◽  
Open Pilot ◽  
Volume Decrease

Objective: To assess the effect of Daflon 500 mg on upper lymphoedema occurring after conventional treatment of breast cancer. Design: Open, pilot, single centre trial. Setting: Hospital outpatients attending a University Hospital. Patients: Ten female patients (aged 44–64 years) whose previous treatment for breast cancer was followed by upper limb lymphoedema (mean (SD) time delay = 17±7 months). Interventions: Oral administration of a daily dose of two tablets of Daflon 500 mg for 6 months. Main outcome measures: Symptoms, affected upper limb volume and parameters of radionuclide lymphoscintigraphy using technetium-99m. Results: All patients experienced improvement of symptoms and limb volume (mean volume decrease of the swollen limb: 6.80%). Functional parameters assessed with scintigraphy were significantly improved (half-life: 147.4 (14.9) to 144.1 (14.9) min, p < 0.01; clearance of the colloid: 25.9 (2.5) to 28.3 (2.8) <l/min, p < 0.05; lymphatic speed of the colloid: 7.7 (0.3) to 8.0 (0.2) cm/min, p < 0.05). Conclusion: These preliminary results suggest that this therapy is effective for the treatment of lymphoedema.

The role of radionuclide lymphoscintigraphy in extremity lymphedema

2006 ◽  
Vol 20 (5) ◽  
pp. 341-344 ◽  
Author(s):  
Zhibin Yuan ◽  
Libo hen ◽  
Quanyong Luo ◽  
Jifang Zhu ◽  
Hankui Lu ◽  
...  
Keyword(s):  
Radionuclide Lymphoscintigraphy

Functional Study of the Limb Lymphatic System

1986 ◽  
Vol 1 (2) ◽  
pp. 129-133 ◽  
Author(s):  
A. Pecking ◽  
R. Cluzan ◽  
J.P. Desprez-Curely ◽  
P. Guérin
Keyword(s):  
Injection Site ◽  
Half Life ◽  
Lymphatic System ◽  
Average Particle Size ◽  
Lymphatic Drainage ◽  
Functional Study ◽  
Average Particle ◽  
Time Activity ◽  
Radionuclide Lymphoscintigraphy ◽  
Two Parameters

Radionuclide lymphoscintigraphy with rhenium sulphide colloid (RSC), average particle size 40 nm was used as a functional test of the limb lymphatic system. When injected subcutaneously in the hand or the foot all the RSC which leave the injection site enters the lymphatic system. From the disappearance time-activity curve detected over the injection site, we calculated the half-life and the lymphatic colloidal clearance (LC) of the RSC. These two parameters appeared to be closely depending on the macrophage function and on the permeability of the initial lymphatics. We also measured the necessary time for RSC to reach the knee or the elbow and calculated a lymphatic speed (LS) closely related to the lymph flow. The study was first carried out on 40 healthy volunteers and then on 221 patients with limb lymphoedemas. The reproducibility of the method was good when 4 days at least separate two functional tests ( r = 0.95 for half-life, r = 0.86 for lymphatic clearance at the injection site and r = 0.93 for lymphatic speed). In addition with the lymphatic images detected 1 h after the injection the functional study may become a useful technique to differentiate the lymphatic drainage diseases.

scholarly journals ASSESSMENT OF LYMPHEDEMA WITH LYMPHOSCINTIGRAPHY: CAN NODAL QUANTIFICATION HELP?

Lymphology ◽  
2021 ◽  
Vol 54 (2) ◽  
Author(s):  
N. Sampathirao ◽  
M. Indirani ◽  
G. Manokaran ◽  
A. Jaykanth ◽  
A. Patel ◽  
...  
Keyword(s):  
Quantitative Analysis ◽  
Lower Limb ◽  
Qualitative Method ◽  
Prospective Observational Study ◽  
Clinical Analysis ◽  
Tracer Uptake ◽  
Qualitative And Quantitative Analysis ◽  
Qualitative And Quantitative ◽  
Radionuclide Lymphoscintigraphy ◽  
Clinical Grading

Lymphoscintigraphy with combined qualitative and quantitative analysis is reported to be a more sensitive approach to diagnose lymphedema in comparison with the conventional clinical analysis. Our study seeks to evaluate the diagnostic performance of lower limb lymphoscintigraphy with amalgamation of qualitative and quantitative analysis by measuring the ilio-inguinal nodal uptake. This prospective observational study was comprised of 86 patients (172 limbs) diagnosed with lower limb lymphedema. After a thorough clinical grading of edema, radionuclide lymphoscintigraphy was performed as per a dedicated institutional protocol. Ilio-inguinal nodal quantification of tracer uptake was computed along with the visual study of the scans. Additionally, the corresponding mean nodal uptake percentage for each grade of lymphedema was assessed and a cut off nodal uptake percentage to differentiate between normal and abnormal limbs was defined. Although quantitative analysis with nodal uptake percentage provides objective criteria to diagnose lymphedema, it can only act as an adjunct to qualitative method without replacing it. Finally, standardization of procedure for quantitative lymphoscintigraphy is needed including the potential for combining both rate of clearance of tracer from injection site and nodal uptake for quantification.

scholarly journals Radionuclide Lymphoscintigraphy in the Diagnosis of Idiopathic Congenital Lymphedema– a Case Report

2018 ◽  
Vol 18 (2) ◽  
pp. 183-185
Author(s):  
Shamim MF Begum ◽  
Nasreen Sultana ◽  
Rahima Parveen ◽  
Amardeep Chaudhury ◽  
Fatima Begum
Keyword(s):  
Family History ◽  
De Novo ◽  
Primary Diagnosis ◽  
Interesting Case ◽  
Genetic Event ◽  
Live Births ◽  
Dysmorphic Features ◽  
Primary Lymphedema ◽  
History Of ◽  
Radionuclide Lymphoscintigraphy

Congenital lymphedema is the rarest form of primary lymphedema, accounting for approximately 1: 60,000 live births. Congenital lymphedema can be classified into familial (hereditary) and idiopathic (non hereditary) subgroups. When congenital lymphedema is of the hereditary form the eponym Milroy disease is applied. Lymphedema without any dysmorphic features and no family history of lymphedema the eponym idiopathic congenital lymphedema is utilized. Etiology of idiopathic primary congenital lymphedema is unknown and a de novo genetic event of genes involved in lymphangiogenesis is a possibility. Radionuclide lymphoscintigraphy is considered as a gold standard for the diagnosis of lymphedema. This reported interesting case was an eleven months old girl having swelling of right lower limb since birth. There was no family history of lymphedema and no any dysmorphic features consistent with Milroy disease. The primary diagnosis was congenital lymphedema of idiopathic (non hereditary) subtype. Lymphoscintigraphic with Technetium-99m (Tc- 99m nanocolloid) revealed no lymphatic channels or inguinal lymph nodes on right side in early or delayed images up to 2 hours views and the diagnosis of primary idiopathic congenital lymphedema was confirmed.Bangladesh J. Nuclear Med. 18(2): 183-185, July 2015

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