Extract from Pink Rock Rose (ECce20) – support to human immune defense

2009 ◽  
Vol 30 (S 01) ◽  
Author(s):  
B Feistel ◽  
B Walbroel
Keyword(s):  
Immune Defense ◽  
Human Immune

scholarly journals Protease-dependent mechanisms of complement evasion by bacterial pathogens

2012 ◽  
Vol 393 (9) ◽  
pp. 873-888 ◽  
Author(s):  
Michal Potempa ◽  
Jan Potempa
Keyword(s):  
Antibacterial Activity ◽  
Complement System ◽  
Antibacterial Activities ◽  
Immune Defense ◽  
Innate Immune ◽  
Human Pathogens ◽  
Human Immune System ◽  
Common Strategy ◽  
Human Immune ◽  
The Complement System

Abstract The human immune system has evolved a variety of mechanisms for the primary task of neutralizing and eliminating microbial intruders. As the first line of defense, the complement system is responsible for rapid recognition and opsonization of bacteria, presentation to phagocytes and bacterial cell killing by direct lysis. All successful human pathogens have mechanisms of circumventing the antibacterial activity of the complement system and escaping this stage of the immune response. One of the ways in which pathogens achieve this is the deployment of proteases. Based on the increasing number of recent publications in this area, it appears that proteolytic inactivation of the antibacterial activities of the complement system is a common strategy of avoiding targeting by this arm of host innate immune defense. In this review, we focus on those bacteria that deploy proteases capable of degrading complement system components into non-functional fragments, thus impairing complement-dependent antibacterial activity and facilitating pathogen survival inside the host.

scholarly journals Human immune system adaptations to simulated microgravity revealed by single-cell mass cytometry

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
J. M. Spatz ◽  
M. Hughes Fulford ◽  
A. Tsai ◽  
D. Gaudilliere ◽  
J. Hedou ◽  
...  
Keyword(s):  
Immune System ◽  
Single Cell ◽  
Cell Mass ◽  
Deep Understanding ◽  
Immune Defense ◽  
Mass Cytometry ◽  
Human Immune System ◽  
Functional Responses ◽  
Human Immune

AbstractExposure to microgravity (µG) during space flights produces a state of immunosuppression, leading to increased viral shedding, which could interfere with long term missions. However, the cellular mechanisms that underlie the immunosuppressive effects of µG are ill-defined. A deep understanding of human immune adaptations to µG is a necessary first step to design data-driven interventions aimed at preserving astronauts’ immune defense during short- and long-term spaceflights. We employed a high-dimensional mass cytometry approach to characterize over 250 cell-specific functional responses in 18 innate and adaptive immune cell subsets exposed to 1G or simulated (s)µG using the Rotating Wall Vessel. A statistically stringent elastic net method produced a multivariate model that accurately stratified immune responses observed in 1G and sµG (p value 2E−4, cross-validation). Aspects of our analysis resonated with prior knowledge of human immune adaptations to µG, including the dampening of Natural Killer, CD4+ and CD8+ T cell responses. Remarkably, we found that sµG enhanced STAT5 signaling responses of immunosuppressive Tregs. Our results suggest µG exerts a dual effect on the human immune system, simultaneously dampening cytotoxic responses while enhancing Treg function. Our study provides a single-cell readout of sµG-induced immune dysfunctions and an analytical framework for future studies of human immune adaptations to human long-term spaceflights.

scholarly journals Youth vocabularies mediated on the webradio about human immune defense against Covid – 19

2020 ◽  
Vol 9 (12) ◽  
pp. e7091210731
Author(s):  
Raimundo Augusto Martins Torres ◽  
Thereza Maria Magalhães Moreira ◽  
Karlla da Conceição Bezerra Brito Veras ◽  
Aretha Feitosa de Araújo ◽  
Edine Dias Pimentel Gomes ◽  
...  
Keyword(s):  
Thematic Analysis ◽  
Health Program ◽  
Signs And Symptoms ◽  
Risk Groups ◽  
Immune Defense ◽  
Vocabulary Knowledge ◽  
Prevention Strategies ◽  
Descriptive Research ◽  
Transmission Prevention ◽  
Human Immune

Describe the vocabulary knowledge of youth son about human immune defense in the presence of Covid 19. Descriptive research, carried out in April 2020, with 64 young high school and university students who participated in the “In Tuning with Health” program on the Radio AJIR website. Knowledge was categorized and analyzed based on the Vocabular Universe and Thematic Analysis. 31 questions-discourses made up the Vocabular Universe of Youths, highlighted for organic and bodily defense, signs and symptoms, forms of transmission, prevention strategies, risk groups, sequelae, immune system, treatment, drugs, vaccine, cure, asymptomatic, social isolation and primary care. Online dialogical communication enabled the exchange of knowledge expressed by experiences in the context of the pandemic in contemporary times. The mediation of youth knowledge about the new coronavirus via web radio was constituted as a practice of educational nursing webcare, motivating health promotion in the context of the pandemic.

Activation of human immune cells by the oncolytic parvovirus H-1 combined with chemotherapeutic or targeted agents

2010 ◽  
Vol 48 (08) ◽  
Author(s):  
M Moehler ◽  
M Sieben ◽  
S Roth ◽  
B Leuchs ◽  
C Dinsart ◽  
...  
Keyword(s):  
Immune Cells ◽  
Targeted Agents ◽  
Human Immune

Is Alzheimer disease a failure of mobilizing immune defense? Lessons from cognitively fit oldest-old

2019 ◽  
Vol 21 (1) ◽  
pp. 7-19 ◽  
Keyword(s):  
Alzheimer Disease ◽  
Cognitive Aging ◽  
Oldest Old ◽  
Adaptive Immune Response ◽  
Effector T Cells ◽  
Immune Defense ◽  
Supporting Evidence ◽  
Therapeutic Approaches ◽  
Related Data ◽  
Adaptive Immune

Multifaceted evidence supports the hypothesis that inflammatory-immune mechanisms contribute to Alzheimer disease (AD) neuropathology and genetic association of several immune specific genes (TREM2, CR1, and CD33) suggests that maladaptive immune responses may be pivotal drivers of AD pathogenesis. We reviewed microglia-related data from postmortem AD studies and examined supporting evidence from AD animal models to answer the following questions: i) What is the temporal sequence of immune activation in AD progression and what is its impact on cognition? ii) Are there discordant, "primed", microglia responses in AD vs successful cognitive aging? iii) Does central nervous system (CNS) repair in aging depend on recruitment of the elements of cellular adaptive immune response such as effector T cells, and can the recruitment of systemic immune cells ameliorate AD neuropathology? iv) How effective are the immune-system-based therapeutic approaches currently employed for the treatment of AD?

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