Venous thromboembolism is the leading direct cause of maternal death. Therefore an understanding of the risk factors, clinical presentation, appropriate investigations (i.e. echocardiogram, V/Q Scan, or CT pulmonary angiography) and the treatment options available for managing patients with suspected and confirmed pulmonary embolism (PE) are essential knowledge on an obstetric unit. The chapter includes information on anticoagulation treatment options and the management of life-threatening PE, when thrombolysis or pulmonary embolectomy may be indicated. Amniotic fluid embolism is discussed, reviewing aetiology, pathophysiology, clinical features, diagnosis, and supportive management. Finally air embolism is discussed, also looking at aetiology, pathophysiology, clinical features, diagnosis, and management, emphasizing, however, that prevention is key.