Vitamin D deficiency and autoimmune thyroid diseases

2015 ◽  
Vol 122 (03) ◽  
Author(s):  
N Körber-Hafner ◽  
C Körber
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

RELATIONSHIP OF VITAMIN D DEFICIENCY AND AUTOIMMUNE THYROID DISEASES

2011 ◽  
Vol 22 ◽  
pp. S87 ◽  
Author(s):  
Gulbuz Sezgin ◽  
M. Esref Ozer ◽  
Oya Uygur Bayramicli ◽  
A. Melih Ozel ◽  
Fehime Aksungar ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Relationship Of

Vitamin D and autoimmune thyroid diseases (part 1)

2021 ◽  
pp. 6-15
Author(s):  
N. V. Volkova ◽  
A. V. Solntseva
Keyword(s):  
Vitamin D ◽  
Autoimmune Diseases ◽  
Immune Cells ◽  
Therapeutic Potential ◽  
Immunosuppressive Agents ◽  
Thyroid Tissue ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Autoimmune Pathology

Autoimmune thyroiditis (AIT) and Graves’ disease (GD) are common autoimmune diseases, and their prevalence assessed as 5 % of general population. Currently, selective immunosuppressive agents for pathogenetic treatment of autoimmune pathology are being developed. Vitamin D with the known anti­inflammatory and immunoregulatory properties, is also of great interest. The first part of the article reviews the roles of various immune cells in the pathogenesis of autoimmune thyroid diseases, which is necessary to reveal the therapeutic potential of calcitriol in these disorders. Classically, AIT was considered to be mediated by T­helpers type 1 (Th1), and GD — by T­helpers type 2 (Th2). This misunderstanding was based on the idea that humoral immunity is controlled by Th2 cytokines, and cellular immunity — by Th1. In the past decades, the role of new subsets of immune cells in the pathogenesis of autoimmune thyroid diseases is being studied, displacing the traditional paradigm of Th1/Th2 dichotomy. It has been established that T­helpers type 17 (Th17) play an important role in the development of various inflammatory and autoimmune diseases, previously classified as Th1­dependent pathologies. The involvement of T­ and B­regulatory lymphocytes in the autoimmune process is also of particular interest. It was found that these cells accumulate in inflamed thyroid tissue in patients with thyroid pathology, but they are unable to suppress the immune response effectively. Further research will help to find out which immune cells can become targets for vitamin D agonists in the complex treatment of autoimmune diseases.

scholarly journals Vitamin D and Autoimmune Thyroid Diseases - a Review

Folia Medica ◽  
2020 ◽  
Vol 62 (2) ◽  
pp. 223-229
Author(s):  
Mariya Zh. Miteva ◽  
Boyan I. Nonchev ◽  
Maria M. Orbetzova ◽  
Snejana D. Stoencheva
Keyword(s):  
Vitamin D ◽  
Lupus Erythematosus ◽  
Thyroid Tissue ◽  
Vitamin D Supplementation ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Local Synthesis ◽  
Autoimmune Thyroid ◽  
Vitamin D Receptors ◽  
The Impact

The essential biological action of vitamin D is regulation of calcium and phosphorus metabolism and preserving bone health. In recent years there have been reports about the extraskeletal actions of vitamin D and its role in the regulation of immune system. Vitamin D supplementation appears to reduce the incidence of cardiovascular diseases, cancer, and infections and be able to reduce all-cause mortality. Deficiency of vitamin D has been found to correlate with the increased incidence of autoimmune diseases, including type 1 diabetes mellitus, rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis. Autoimmune thyroid diseases (AITD), including Graves’ disease, Hashimoto’s thyroiditis are relatively common autoimmune disorders affecting more than 5% of general population. It has been shown that vitamin D receptors (VDR) and 1-alpha hydroxylase are expressed in papillary thyroid cancer and normal thyroid tissue, suggesting local synthesis of 1,25(OH)2D in the thyroid. While VDR gene polymorphism has been found in much research to be associated with AITDs, very few studies have examined the impact of vitamin D deficiency on the incidence of AITDs in humans with conflicting results. This review focuses on the association between vitamin D and autoimmune thyroid diseases and summarizes the results of vitamin D supplementation studies in patients with AITD.

Is vitamin D a player or not in the pathophysiology of autoimmune thyroid diseases?

2015 ◽  
Vol 14 (5) ◽  
pp. 363-369 ◽  
Author(s):  
Federica D'Aurizio ◽  
Danilo Villalta ◽  
Paolo Metus ◽  
Paolo Doretto ◽  
Renato Tozzoli
Keyword(s):  
Vitamin D ◽  
Thyroid Diseases ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

scholarly journals Serum Vitamin D Status in Newly Diagnosed Hypothyroid Patients

2019 ◽  
Vol 22 (1) ◽  
pp. 47-52
Author(s):  
Naheed Khan ◽  
Sadia Sultana ◽  
Madhuchhanda Hazra Mou ◽  
Suraya Sarmin
Keyword(s):  
Vitamin D ◽  
Muscle Development ◽  
Serum Vitamin ◽  
Thyroid Diseases ◽  
Vdr Gene ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Serum Vitamin D ◽  
The Mean ◽  
Hypothyroid Patients

More than billion people worldwide are vitamin D deficient. It is recognized to have function in bone and muscle development by regulating calcium and phosphorus metabolism. Its role as an immune modulator has recently been discovered. Deficiency of vitamin D has been discovered to be associated with various cardiovascular, infectious, malignant, hypothyroidism and autoimmune thyroid diseases. Prevalence of hypothyroidism and hypovitaminosis D in Bangladesh is not known but supposed to be high because our neighbor country India has high prevalence. Vitamin D mediates its effect through binding to vitamin D receptor (VDR) and activation of VDR- responsive genes. VDR gene polymorphism was found to be associated with autoimmune thyroid diseases. On the other way hypothyroidism either decreases the metabolism of vitamin D or prevents to activate it. A total of 38 adult hypothyroid otherwise healthy patients and age, sex, BMI, socioeconomic status matched euthyroid adults were included in the study. The mean age in the hypothyroid group was 37.82 ± 7.95 years and in the euthyroid group was 34.84 ± 8.61 years. Male participants were14 and female participants were 24 in each group. The mean value of serum vitamin D of healthy group was 17.11 ± 5.62 ng/ml  and in hypothyroid patients was 13.16 ± 4.29 ng/ml., Hypothyroid patients had significantly lower levels of serum Vitamin D3 as compared to controls (p =0.037,<0.05). Negative correlation was observed between serum TSH and serum vitamin D (r=-.119, p=.034), moderate positive correlation was observed between serum FT4 and serum vitamin D ((r=0.457, p=0.01, P<0.05). Bangladesh J. Nuclear Med. 22(1): 47-52, Jan 2019  

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