Analysis of association of vitamin D receptor gene Cdx2 (rs11568820) polymorphism with autoimmune thyroid diseases

2018 ◽  
Author(s):  
Adam Maciejewski ◽  
Michal J Kowalczyk ◽  
Teresa Gasinska ◽  
Waldemar Herman ◽  
Anna Szeliga ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Receptor Gene ◽  
Thyroid Diseases ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Polymorphisms in the vitamin D receptor gene and risk of autoimmune thyroid diseases: a meta-analysis

Endocrine ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 318-326 ◽  
Author(s):  
Ming Feng ◽  
Hua Li ◽  
Su-Fang Chen ◽  
Wei-Fang Li ◽  
Fang-Bin Zhang
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Meta Analysis ◽  
Receptor Gene ◽  
Thyroid Diseases ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid

Vitamin D Receptor Gene (VDR) Polymorphisms Are Not Associated with Autoimmune Thyroid Disease Risk in Turner Syndrome Patients

2011 ◽  
pp. P3-594-P3-594
Author(s):  
Bianca Bianco ◽  
Ieda Therezinha do Nascimento Verreschi ◽  
Kelly Cristina Oliveira ◽  
Alexis Dourado Guedes ◽  
Caio Parente Barbosa ◽  
...  
Keyword(s):  
Vitamin D ◽  
Turner Syndrome ◽  
Vitamin D Receptor ◽  
Thyroid Disease ◽  
Autoimmune Thyroid Disease ◽  
Disease Risk ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Autoimmune Thyroid ◽  
Vdr Polymorphisms

scholarly journals Vitamin D Receptor Gene Polymorphisms and Autoimmune Thyroiditis: Are They Associated with Disease Occurrence and Its Features?

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Adam Maciejewski ◽  
Michał J. Kowalczyk ◽  
Waldemar Herman ◽  
Adam Czyżyk ◽  
Marta Kowalska ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Receptor ◽  
Autoimmune Thyroiditis ◽  
Gene Polymorphisms ◽  
Receptor Gene ◽  
Thyroid Volume ◽  
Vitamin D Receptor Gene ◽  
Polish Population ◽  
Nucleotide Polymorphisms ◽  
Autoimmune Thyroid

Purpose. Vitamin D, besides its role in calcium-phosphorus metabolism, turned out to play a significant immunomodulating function. Until now four single nucleotide polymorphisms of vitamin D receptor gene (VDR), rs2228570 (FokI), rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI), have been studied in autoimmune thyroid disorders, with conflicting results. Another functional polymorphism of the VDR gene, rs11568820 (Cdx2), has been shown to influence the immune system, although it has not been studied for its association with autoimmune thyroiditis to date. Therefore, the study aimed to evaluate the association of these five VDR gene polymorphisms with susceptibility to autoimmune thyroiditis among Caucasian Polish population. A relationship between the studied polymorphisms and selected clinical features of the disease was additionally assessed. Methods. 223 patients with autoimmune thyroiditis and 130 control subjects were enrolled in the study. VDR polymorphisms were studied by PCR-RFLP or TaqMan real-time PCR. Results. Allele and genotype distributions of any of the studied polymorphisms did not differ significantly between patients and controls. Similarly, frequencies of haplotypes derived from rs1544410-rs7975232-rs731236 (BsmI-ApaI-TaqI) polymorphisms were not significantly different in the two studied groups. However, a weak association between rs1544410 (BsmI) or rs7975232 (ApaI) VDR polymorphisms and thyroid volume was found (p = 0.03 and p = 0.04, resp.). Conclusions. Our results suggest that VDR gene is not a major susceptibility factor for autoimmune thyroiditis development, at least in Caucasian Polish population.

803: Interactions Between Ultraviolet Radiation and Polymorphisms in the Vitamin D Receptor Gene Mediate Prostate Cancer Susceptibility

2006 ◽  
Vol 175 (4S) ◽  
pp. 260-260
Author(s):  
Nicholas J. Rukin ◽  
Samuel J. Moon ◽  
Dhaval Bodiwala ◽  
Christopher J. Luscombe ◽  
Mark F. Saxby ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Ultraviolet Radiation ◽  
Vitamin D Receptor ◽  
Cancer Susceptibility ◽  
Receptor Gene ◽  
Vitamin D Receptor Gene ◽  
Prostate Cancer Susceptibility

487: Vitamin D Receptor Gene Haplotypes and Prostate Cancer in Hispanic and Non-Hispanic White Men: Results from a Case-Control Genetic Association Study

2006 ◽  
Vol 175 (4S) ◽  
pp. 158-158
Author(s):  
Kathleen C. Torkko ◽  
Phuong Mai ◽  
Robin J. Leach ◽  
Betsy A. Higgins ◽  
Adrie Van Bokhoven ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Vitamin D ◽  
Association Study ◽  
Vitamin D Receptor ◽  
Genetic Association Study ◽  
Receptor Gene ◽  
White Men ◽  
Case Control ◽  
Vitamin D Receptor Gene ◽  
Hispanic White
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