scholarly journals Direct Oxytosylation of 8-Amidoquinolines by Koser’s Reagent: An Efficient Strategy for 5-Substituted 8-Amidoquinolines

Synthesis ◽  
2018 ◽  
Vol 50 (20) ◽  
pp. 4089-4096 ◽  
Author(s):  
Basireddy Reddy ◽  
Zubeda Begum ◽  
G. Bhavani ◽  
B. Sridhar
Keyword(s):  
Functional Groups ◽  
Aromatic Ring ◽  
Metal Free ◽  
Efficient Strategy ◽  
Koser's Reagent

A metal-free remote oxytosylation of 8-amidoquinolines has been achieved using Koser’s reagent to produce 5-tosyloxy-8-amidoquinolines in good yields. This method is compatible with various functional groups present on the aromatic ring.

An Efficient Substrate-Induced Method for the Synthesis of CF3-Substituted Cyclopropanes by Metal-Free Reaction of Trifluoromethyl Styrylisoxazoles with Nitromethane

Synthesis ◽  
2020 ◽  
Author(s):  
Feng Li ◽  
Hai Ma ◽  
Qing-he Zhao ◽  
Guang-hao Yu ◽  
Ye-chen Meng ◽  
...  
Keyword(s):  
Functional Groups ◽  
Phase Transfer ◽  
Cyclization Reaction ◽  
Metal Free ◽  
Tert Butyl ◽  
Pharmacological Interest ◽  
Substituted Cyclopropanes

AbstractA series of (trifluoromethyl)cyclopropanes (TFCPs) tolerating a broad range of functional groups, known as tert-butyl bioisosteres, have been obtained from the cyclization reaction between nitromethane­ and 5-[β-(trifluoromethyl)styryl]isoxazoles in 70–94% yields and 75:25 to 90:10 dr. This method offers practical access to this cyclopropyl moiety of pharmacological interest, employing an inorganic base under phase-transfer conditions.

Deuterative cyclization of sulfanyl 1,6-diynes: complete and monodeuteration of functional groups on heterocycles

2015 ◽  
Vol 2 (3) ◽  
pp. 201-205 ◽  
Author(s):  
Yukiteru Ito ◽  
Mitsuhiro Yoshimatsu
Keyword(s):  
Transition Metal ◽  
Exchange Reaction ◽  
Functional Groups ◽  
Reductive Cyclization ◽  
Metal Free ◽  
Sodium Borodeuteride

Regioselective H/D exchange reaction of functional groups on heterocycles proceeded via a transition metal-free reductive cyclization of sulfanyl 1,6-diynes using sodium borodeuteride/ethanol-D1.

Ultrahigh sensitive metal-free SERS platforms by functional-groups

2018 ◽  
Vol 263 ◽  
pp. 258-265 ◽  
Author(s):  
Ruey-Chi Wang ◽  
En-Cheng Kung ◽  
Yu-Hsuan Chen
Keyword(s):  
Functional Groups ◽  
Metal Free

scholarly journals The cumene/O2 system: a very simple tool for the radical chain oxidation of some functional groups

2017 ◽  
Vol 41 (15) ◽  
pp. 6981-6985 ◽  
Author(s):  
A. Malekafzali ◽  
K. Malinovska ◽  
F. W. Patureau
Keyword(s):  
Functional Groups ◽  
Radical Chain ◽  
Oxidation Method ◽  
Chain Oxidation ◽  
Metal Free ◽  
Radical Chain Oxidation ◽  
System A ◽  
Simple Tool ◽  
Free Oxidation

Just boil it in cumene! A general metal-free oxidation method is described.

Direct Propargylation of ortho-Quinone Methides with Alkynyl Zinc Reagents: An Application to the One-Pot Synthesis of 2,3-Disubstituted Benzofurans

Synlett ◽  
2020 ◽  
Vol 31 (08) ◽  
pp. 818-822
Author(s):  
Hongjun Ren ◽  
Manman Sun ◽  
Jinyu Song ◽  
Lei Wang ◽  
Wenguang Yin ◽  
...  
Keyword(s):  
Transition Metal ◽  
Functional Group ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Efficient Strategy ◽  
One Pot Synthesis ◽  
Subsequent Cyclization ◽  
The One

A transition-metal-free propargylation of ortho-quinone methides (o-QMs) with alkynyl zinc reagents was achieved. A conjugate alkynylation of an o-QM and subsequent cyclization sequence in the presence of KOt-Bu for the synthesis of 2,3-disubstituted benzofurans in one pot was developed. This efficient strategy exhibits good functional-group compatibility and gives moderate to good yields. The present reaction might serve as an attractive method for the synthesis of polysubstituted benzofurans.

Synthesis of fused benzimidazoles via successive nucleophilic additions of benzimidazole derivatives to arynes under transition metal-free conditions

2018 ◽  
Vol 5 (10) ◽  
pp. 1639-1642 ◽  
Author(s):  
Bingnan Li ◽  
Shaoyu Mai ◽  
Qiuling Song
Keyword(s):  
Transition Metal ◽  
Benzimidazole Derivatives ◽  
Nucleophilic Additions ◽  
Metal Free ◽  
Efficient Strategy

An expedient and efficient strategy was developed for the synthesis of benzimidazole derivatives from aryne precursors under transition metal-free conditions.

Biomass-derived phosphorus-doped carbon materials as efficient metal-free catalysts for selective aerobic oxidation of alcohols

2019 ◽  
Vol 21 (19) ◽  
pp. 5274-5283 ◽  
Author(s):  
Xiwei Hu ◽  
Mengying Fan ◽  
Yangyang Zhu ◽  
Qian Zhu ◽  
Qiang Song ◽  
...  
Keyword(s):  
Functional Groups ◽  
Carbon Materials ◽  
Structural Characteristics ◽  
Aerobic Oxidation ◽  
Metal Free ◽  
Oxidation Of Alcohols ◽  
Selective Aerobic Oxidation ◽  
Phosphorus Doped

Heteroatom-doped carbon materials (HDCMs) with abundant active functional groups and stable structural characteristics are promising catalysts for eco-friendly metal-free catalysis.

scholarly journals K2S2O8-Promoted Aryl Thioamides Synthesis from Aryl Aldehydes Using Thiourea as the Sulfur Source

Molecules ◽  
2018 ◽  
Vol 23 (9) ◽  
pp. 2225 ◽  
Author(s):  
Yongjun Bian ◽  
Xingyu Qu ◽  
Yongqiang Chen ◽  
Jun Li ◽  
Leng Liu
Keyword(s):  
Transition Metal ◽  
Functional Groups ◽  
Sulfur Atom ◽  
Coupling Reaction ◽  
Sulfur Source ◽  
Atom Transfer ◽  
Free Condition ◽  
Metal Free ◽  
Aryl Aldehydes ◽  
Three Component Coupling

Thiourea as a sulfur atom transfer reagent was applied for the synthesis of aryl thioamides through a three-component coupling reaction with aryl aldehydes and N,N-dimethylformamide (DMF) or N,N-dimethylacetamide (DMAC). The reaction could tolerate various functional groups and gave moderate to good yields of desired products under the transition-metal-free condition.

Facile synthesis of 3-amino-5-aryl-1,2,4-oxadiazoles via PIDA-mediated intramolecular oxidative cyclization

RSC Advances ◽  
2016 ◽  
Vol 6 (59) ◽  
pp. 54277-54280 ◽  
Author(s):  
Kuan Lu ◽  
Liancheng Duan ◽  
Boxuan Xu ◽  
Weile Yin ◽  
Di Wu ◽  
...  
Keyword(s):  
Functional Groups ◽  
Simple Procedure ◽  
Oxidative Cyclization ◽  
Ambient Condition ◽  
Facile Synthesis ◽  
Metal Free ◽  
Intramolecular Oxidative Cyclization

Advantages: ambient condition and simple procedure. Additive and metal free method. Up to 25 examples and 79% yield. Wide functional groups tolerance.

scholarly journals Characterization and Photoprotector Activity of Endophytic Fungal Pigments from Coastal Plant Sarang Semut (Hydnophytum formicarum)

2016 ◽  
Vol 19 (1) ◽  
pp. 1
Author(s):  
Mada Triandala Sibero ◽  
Kustiariyah Tarman ◽  
Novriyandi Hanif
Keyword(s):  
Functional Groups ◽  
Aromatic Ring ◽  
Endophytic Fungus ◽  
Sun Protection ◽  
Black Pigment ◽  
Protection Factor ◽  
Coastal Plant ◽  
Sun Protection Factor ◽  
Fungal Pigments

Endophytic fungus RS3 isolated from coastal plant sarang semut (Hydnophytum formicarum) produced extracellular black pigment. The aims of this research were to obtain the pigment, to characterize and to determine the photoprotector activity. This research was conducted into several steps, that were determination of the best precipitating agent, characterization using instrument and solubility analysis, and analysis of Sun Protection Factor (SPF). Results showed the pigment was precipitated using acid solvent with pH ≤ 2.5. Functional groups of pigment were hydroxyl, aromatic ring, phenol and amine. According to its characteristics, black pigment produced by RS3 isolate was proposed as melanin. The photoprotector analysis showed the SPF value was 11.33.

Sign in / Sign up

Export Citation Format

Share Document