Evaluation of antioxidant, photoprotective and antinociceptive activities of Marcetia macrophylla extract: potential for formulation of sunscreens

The antioxidant, photoprotective and antinociceptive Marcetia macrophylla active extract was investigated as an active ingredient in a sunscreen cream formulation. Thus, the M. macrophylla extract showed IC50 of 3.43 mg/ml of the antioxidant (DPPH∙ scavenging test) and Sun Protection Factor of 20.25 (SPF/UV-B, at 250 µg/ml) and UV-A of 78.09% (photobleaching trans-resveratrol test). The antinociceptive activity was superior to all standards tested using the in vivo acetic acid-induced writhing test (99.14% at the dose of 200 mg/kg) and the high-performance liquid chromatography coupled with diode array detector and mass spectroscopy multi-stage (HPLC-DAD-MS/MS) enabled the structural characterization of the quercetin-3-O-hexoside, quercetin-3-O-pentoside and quercetin-3-O-desoxihexoside. The pharmaceutical formulation containing the Marcetia macrophylla crude active extract was prepared and the physicochemical tests (organoleptic characteristics, pH analysis and centrifugation), the in vitro UVB (sun protection factor, SPF) and UVA (β-carotene) using the spectroscopic method were investigated. The formulation showed satisfactory results concerning the physicochemical parameters evaluated and active against the UV test. Thus, M. macrophylla showed biological activities with potential use in pharmaceutical preparations.

Knowledge and behavior of Lebanese parents regarding melanoma prevention in public and private school children

Aim: Assess the knowledge and behavior of Lebanese parents when it comes to melanoma and its prevention in children. Methods: A survey, to be completed by parents, was sent through children from three schools. Results: During sun exposure only 23.5% of 1012 respondents were always covering enough areas of their children's skin and 74.1% did not always apply sunscreen to their children. Parents of private school children were three times more likely to apply sunscreen to their children when exposed to sun, four times more likely to reapply sunscreen every 2–3 h and 21 times more likely to use a higher sun protection factor. Conclusion: Sun protection in children is insufficient and sunburns are frequent, illustrating the need for melanoma awareness campaigns.

Innovative Skin Product O/W Emulsions Containing Lignin, Multiwall Carbon Nanotubes and Graphene Oxide Nanoadditives with Enhanced Sun Protection Factor and UV Stability Properties

In the present study, oil-in-water (O/W) sunscreen emulsions were prepared containing different portions of lignin (LGN), multiwall carbon nanotubes (MWCNTs) and graphene oxide (GO) nanoadditives. The stability in terms of pH and viscosity of emulsions was thoroughly studied for up to 90 days, exhibiting high stability for all produced O/W emulsions. The antioxidant activity of emulsions was also analyzed, presenting excellent antioxidant properties for the emulsion that contains LGN due to its phenolic compounds. Moreover, the emulsions were evaluated for their ultraviolet (UV) radiation protection ability in terms of sun protection factor (SPF) and UV stability. SPF values varied between 6.48 and 21.24 while the emulsion containing 2% w/v MWCNTs showed the highest SPF index and all samples demonstrated great UV stability. This work hopefully aims to contributing to the research of more organic additives for cosmetic application with various purposes.

Nilai Sun Protection Factor (SPF) pada Sediaan Lotion Ekstrak Etanol Daun Jambu Air (Syzygium aqueum)

Indonesia merupakan negara beriklim tropis dimana sangat memungkinkan kulit untuk terus terpapar sinar matahari. Radikal bebas berupa sinar ultraviolet dari matahari yang berlebih akan menyebabkan kerusakan pada kulit. Penggunaan lotion yang mengandung antioksidan dapat dilakukan untuk melindungi kulit dari paparan radikal bebas. Daun jambu air (Syzygium aqueum) merupakan salah satu tumbuhan yang memiliki aktivitas antioksidan. Senyawa myricetin dalam tanaman jambu air memiliki aktivitas sebagai UV protektor. Daun jambu air diekstraksi menggunakan pelarut etanol 96% dengan metode maserasi. Pengujian aktivitas antioksidan dilakukan menggunakan metode DPPH dengan vitamin C sebagai pembanding. Pengujian nilai SPF dilakukan menggunakan spektrofotometri UV-Vis yang didasarkan pada persamaan Mansur. Lotion Ekstrak etanol daun jambu air dilakukan pengujian aktivitas antioksidan, nilai SPF dan evaluasi organoleptik, homogenitas, pH, daya sebar dan daya lekat selama 4 minggu. Hasil menunjukkan bahwa Ekstrak dan sediaan lotion ekstrak etanol daun jambu air (Syzygium aqueum) memiliki aktivitas antioksidan sangat kuat dan sedang, sedangkan nilai SPF-nya termasuk kedalam kategori proteksi ultra dan maksimal.

Intsia bijuga Heartwood Extract and Its Phytosome as Tyrosinase Inhibitor, Antioxidant, and Sun Protector

Intsia bijuga (Colebr.) wood (Indonesian: Merbau) is commercial wood with high economic value and is most commonly found in Indonesia. Intsia wood extractives have biological activities related to their potential as natural active ingredients for antiaging cosmetics This study aimed to select the best extraction solvent and phytosome formulation of I. bijuga heartwood extract as an active ingredient for topical antiaging cosmetics. There were five and three variations on extraction solvent and phytosome formulation, respectively. Three main antiaging activity parameters, namely antioxidant, antityrosinase, and sun protection factor (SPF) values, were considered in selecting the best extract and phytosome formula. The results showed that 50% ethanol possessed good antioxidant and antityrosinase activity, but was lower in SPF value, which was significantly different than in other extracts. The phytochemical profile revealed robidanol and robinetin as the main constituent in five I. bijuga extracts. Phytosome F3 possessed high antioxidant, antityrosinase, and SPF values compared to other 50% ethanol phytosome extracts. It could be concluded that I. bijuga ethanol extracts and its phytosome are potent enough to be developed as an antiaging active ingredient in topical use cosmetics.