Laparoscopic Finding of Ectopic Adrenocortical Tissue in a 2-Year-Old Boy with Vanishing Testis

AbstractEctopic adrenocortical tissue (EAT) along the spermatic cord is an unusual condition in children. The author reports on a 2-year-old boy with impalpable testis. On laparoscopy, EAT was detected along the hypotrophic spermatic vessels and excised. These remnants should be removed to prevent hormone production or malignant transformation.

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Impalpable Testis: Evaluation of Diagnostic and Treatment Procedures and Our Treatment Protocol

BioMed Research International ◽

10.1155/2018/3143412 ◽

2018 ◽

Vol 2018 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Ivana Fratrić ◽

Dragan Šarac ◽

Jelena Antić ◽

Marina Đermanov ◽

Radoica Jokić

Keyword(s):

Retrospective Study ◽

Spermatic Cord ◽

Inguinal Canal ◽

Treatment Protocol ◽

Diagnostic Procedures ◽

Final Diagnosis ◽

Impalpable Testis ◽

Two Stages ◽

Treatment Procedures ◽

Abdominal Testis

Introduction. The aim of this study is to present our treatment protocol for impalpable testis. Material and Methods. In a retrospective study we analyzed clinical data including diagnostic procedures, intraoperative findings, final diagnosis, treatment modality, and outcome of patients with impalpable testis who underwent surgery from January 2010 until December 2015. Results. Ninety-one patients were admitted under the diagnosis of impalpable testis. In 39 patients ultrasound detected testis in the inguinal canal and orchidopexy was done. In 25 patients (48.08%) laparoscopy showed the entrance of the spermatic cord into the inguinal canal. Open exploration of the inguinal canal was done, testicular remnant removed, and appropriate testicular prosthesis implanted. Twenty patients (20/52) underwent orchidopexy of the abdominal testis (46.51%), 4 of which underwent Fowler-Stevens procedure in two stages, and in 16 patients deliberation of the testis and spermatic cord was sufficient to place the testis into the scrotum. Conclusions. Excision of the testicular nubbin is highly recommendable, as well as implantation of the testicular prosthesis at the time of orchiectomy.

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Adrenocorticotropin Production by a Mammary Carcinoma

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100079759 ◽

1977 ◽

Vol 35 ◽

pp. 462-463

Author(s):

K.S. McCarty ◽

N.R. Wallace ◽

W. Litaker ◽

S. Wells ◽

G. Eisenbarth

Keyword(s):

Adrenocorticotropic Hormone ◽

Small Cell ◽

Hormone Production ◽

Carcinoma Of The Breast ◽

Ectopic Acth ◽

Ultrastructural Studies ◽

Subcutaneous Metastases ◽

Ectopic Acth Production ◽

The Right ◽

Pituitary Carcinomas

The production of adrenocorticotropic hormone by non-pituitary carcinomas has been documented in several tumors, most frequently small cell carcinoma of the lung, islet cell carcinomas of the pancreas, thymomas and carcinoids. Electron microscopy of these tumors reveals typical membrane-limited "neurosecretory" granules. Confirmation of the granules as adrenocorticotropin (ACTH) requires the use of OsO4 as a primary fixative to give the characteristic cored granule appearance in conjunction with immunohistochemical demonstration of the hormone peptide. Because of the rarity of ectopic ACTH production by mammary carcinomas and the absence of appropriate ultrastructural studies in the two examples of such ectopic hormone production in the literature of which we are aware (1,2), we present biochemical and ultrastructural data from a carcinoma of the breast with apparent ACTH production.The patient had her primary tumor in the right breast in 1969. The tumor recurred as visceral and subcutaneous metastases in 1976 and again in 1977.

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Annulate lamellae in the Sertoli cells of guinea pig testis after unilateral torsion of the spermatic cord

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100111094 ◽

1984 ◽

Vol 42 ◽

pp. 196-197

Author(s):

J. Chakraborty ◽

A. P. Sinha Hikim ◽

J. S. Jhunjhunwala

Keyword(s):

Sertoli Cells ◽

Guinea Pigs ◽

Spermatic Cord ◽

Present Report ◽

Cell Types ◽

Annulate Lamellae ◽

Spermatogenic Cells ◽

Electron Microscopic ◽

Structural Details ◽

First Time

Although the presence of annulate lamellae was noted in many cell types, including the rat spermatogenic cells, this structure was never reported in the Sertoli cells of any rodent species. The present report is based on a part of our project on the effect of torsion of the spermatic cord to the contralateral testis. This paper describes for the first time, the fine structural details of the annulate lamellae in the Sertoli cells of damaged testis from guinea pigs.One side of the spermatic cord of each of six Hartly strain adult guinea pigs was surgically twisted (540°) under pentobarbital anesthesia (1). Four months after induction of torsion, animals were sacrificed, testes were excised and processed for the light and electron microscopic investigations. In the damaged testis, the majority of seminiferous tubule contained a layer of Sertoli cells with occasional spermatogonia (Fig. 1). Nuclei of these Sertoli cells were highly pleomorphic and contained small chromatinic clumps adjacent to the inner aspect of the nuclear envelope (Fig. 2).

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Application of Transmission Electron Microscope and Scanning Electron Microscope in experimental tumor studies

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100159084 ◽

1990 ◽

Vol 48 (3) ◽

pp. 306-307

Author(s):

Gao Fengming

Keyword(s):

Electron Microscope ◽

Scanning Electron Microscope ◽

Malignant Transformation ◽

Transmission Electron Microscope ◽

Experimental Tumor ◽

Transmission Electron ◽

Embryo Cells ◽

Tumor Studies ◽

Scanning Electron

Transmission electron microscope(TEM) and scanning electron microscope(SEM) were widely used in experimental tumor studies. They are useful for evaluation of cellular transformation in vitro, classification of histological types of tumors and treating effect of tumors. We have obtained some results as follows:1. Studies on the malignant transformation of mammalian cells in vitro. Syrian golden hamster embryo cells(SGHEC) were transformed in vitro by ThO2 and/or ore dust. In a few days after dust added into medium, some dust crystals were phagocytized. Two weeks later, malignant transformation took place. These cells were of different size, nuclear pleomorphism, numerous ribosomes, increasing of microvilli on cell surface with various length and thickness, and blebs and ruffles(Figs. 1,2). Myelomonocytic leukemic transformation of mouse embryo cells(MEC) was induced in vitro by 3H-TdR. Transformed cells were become round from fusiform. The number of mitochondria and endoplasmic reticulum was reduced, ribosomes and nucleoli increased, shape of nuclei irregular, microvilli increased, and blebs and ruffles appeared(Fig. 3).

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