The role of gamma probe activity counts in minimally invasive parathyroidectomy

2004 ◽  
Vol 43 (06) ◽  
pp. 190-194 ◽  
Author(s):  
A. Aydın ◽  
C. Tassci ◽  
K. Atila ◽  
M. A. Koçdor ◽  
A. Sevinç ◽  
...  
Keyword(s):  
Gamma Probe ◽  
Minimally Invasive Parathyroidectomy ◽  
The Other ◽  
Rank Test ◽  
Test Results ◽  
Invasive Parathyroidectomy ◽  
The Mean ◽  
99Mtc Mibi ◽  
Wilcoxon Rank Test

Summary Aim: The benefit of preoperative gamma probe in the diagnosis of adenoma in patients with histopathologically proven parathyroid (PT) adenomas was examined. Patients, material, methods: 20 patients with positive 99mTc MIBI uptake in PT scintigraphy with primary hyper-parathyroidism were enrolled in this study. 740 MBq 99mTc MIBI were injected 3 h before operation. Counts of four PT regions were obtained with gamma probe before surgery in the operation room. All suspected PT adenomas were resected and histopathologically diagnosed as adenomas. We also obtained counts of the resection region and the resected adenoma with gamma probe after the parathyroidectomy. Preoperative counts of adenoma bearing regions (ABR), non-adenoma bearing regions (NABR), postoperative resection region (PRR), resected adenoma counts (RA) were registered. Statistical analysis was performed by Wilcoxon rank test. Results: The mean counts of ABR, NABR, the PRR and RA were 462 ± 106, 230 ± 66, 164 ± 42, 374 ± 87, respectively. The mean counts from ABR were twofold higher than those of NABR. The PRR mean counts decreased by 64% when compared to the mean counts of ABR and by 55% when compared to the mean counts of RA. The differences in mean counts of ABR and NABR, PRR and ABR, PRR and RA (p <0.01) turned out as statistically significant. Discussion: According to our preliminary results, the region with the highest counts is at least 2 ± 0,4 times higher than the mean of the other three PT regions. Thus, it seems to be significant for PT adenoma. Resection of adenoma may be accepted as successful, if the count of ABR decreased more than 64% with decreased postoperative parathormone levels. Conclusion: This technique should not yet be applied instead of parathormone measurement or frozen technique. But it may replace the frozen technique used for confirmation of the diagnosis during the operation in the future.

scholarly journals Role of gamma probes in performing minimally invasive parathyroidectomy in patients with primary hyperparathyroidism: optimization of preoperative and intraoperative procedures

2003 ◽  
pp. 7-15 ◽  
Author(s):  
D Rubello ◽  
A Piotto ◽  
D Casara ◽  
PC Muzzio ◽  
B Shapiro ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Minimally Invasive ◽  
Parathyroid Adenoma ◽  
Gamma Probe ◽  
Minimally Invasive Parathyroidectomy ◽  
Operating Theatre ◽  
Neck Ultrasound ◽  
Invasive Parathyroidectomy ◽  
Guided Surgery

OBJECTIVE: In the last decade, surgery of primary hyperparathyroidism (HPT) due to a solitary adenoma has moved on from the traditional wide bilateral neck exploration (BNE) to more limited approaches such as unilateral neck exploration and minimally invasive parathyroidectomy. DESIGN: To define the role of intraoperative gamma probe and injection of a low (99m)Tc-MIBI dose in performing minimally invasive radio-guided surgery (MIRS) in HPT patients with a solitary parathyroid adenoma. METHODS: From September 1999 to July 2002, 214 patients with primary HPT entered the study. All patients were preoperatively investigated by a (99m)Tc-pertechnetate/MIBI subtraction scan and high-resolution neck ultrasound. The intraoperative technique we developed differs from other previously described techniques being based on the injection of a low (37 MBq) MIBI dose in the operating theatre a few minutes before the beginning of intervention. RESULTS: On the basis of scan/ultrasound findings 147 patients were selected for a MIRS and 144 of them (98%) were successfully treated by this approach: a solitary parathyroid adenoma was removed through a small 2-2.5 cm skin incision with a mean operative time of 35 min, and a mean hospital stay of 1.2 days. In the other 67 patients with scan/ultrasound evidence of concomitant nodular goiter (n=45) or multi-gland disease (n=13) or with a negative scan (n=9), the gamma probe was utilized during a traditional BNE. A low 37 MBq MIBI dose proved to be sufficient to perform a MIRS; moreover it delivered to the patient and surgeon a low, negligible, radiation exposure dose. CONCLUSIONS: The combination of a (99m)Tc-pertechnetate/MIBI subtraction scan and neck ultrasound appears to be an accurate imaging protocol in selecting primary HPT patients as candidates for a MIRS. A MIBI dose as low as 37 MBq injected in the operating theatre just before the start of surgery appears to be adequate to perform radio-guided surgery.

Effect of thromboxane antagonists on ozone-induced airway responses in dogs

1990 ◽  
Vol 69 (3) ◽  
pp. 880-884 ◽  
Author(s):  
G. L. Jones ◽  
C. G. Lane ◽  
P. M. O'Byrne
Keyword(s):  
Airway Hyperresponsiveness ◽  
The Other ◽  
Receptor Antagonists ◽  
Thromboxane Receptor ◽  
Before And After ◽  
The Mean ◽  
Airway Responses ◽  
Control Infusion

Airway hyperresponsiveness after inhaled ozone in dogs may occur as a result of thromboxane release in the airway. In this study, two thromboxane receptor antagonists, L-655,240 and L-670,596, were used in doses that inhibit the response to an inhaled thromboxane mimetic, U-46619, to determine further the role of thromboxane in ozone-induced airway hyperresponsiveness. Dogs were studied on 2 days separated by 1 wk. On each day, the dogs inhaled ozone (3 ppm) for 30 min. On one randomly assigned day, 10 dogs received an infusion of L-655,240 (5 mg.kg-1.h-1) and 5 dogs received an infusion of L-670,596 (1 mg.kg-1.h-1); on the other day dogs received a control infusion. Airway responses to doubling doses of acetylcholine were measured before and after inhalation of ozone and were expressed as the concentration of acetylcholine giving a rise in resistance of 5 cmH2O.l-1.s from baseline (acetylcholine provocation concentration). The development of airway hyperresponsiveness after ozone was not inhibited by the thromboxane antagonists. The mean log difference in the acetylcholine provocative concentration before and after ozone on the L-655,240 treatment day was 0.62 +/- 0.12 (SE) and on the control day was 0.71 +/- 0.12 (P = 0.48); on the L-670,596 treatment day the mean log difference was 0.68 +/- 0.15 (SE) and on the control day it was 0.75 +/- 0.19 (P = 0.45). These results do not support an important role for thromboxane in causing ozone-induced airway hyperresponsiveness.

Minimally Invasive Parathyroidectomy: The Role of Radio-Guided Surgery

2002 ◽  
Vol 112 (12) ◽  
pp. 2166-2169 ◽  
Author(s):  
Ashok R. Shaha ◽  
Snehal G. Patel ◽  
Bhuvanesh Singh
Keyword(s):  
Minimally Invasive ◽  
Minimally Invasive Parathyroidectomy ◽  
Invasive Parathyroidectomy ◽  
Guided Surgery

scholarly journals Pelatihan Empati Untuk Meningkatkan Pemaafan Pada Mahasiswi Korban Kekerasan Dalam Hubungan Pacaran

2019 ◽  
Vol 2 (2) ◽  
pp. 147-158
Author(s):  
Faisal Adnan Reza ◽  
Rahma Widyana
Keyword(s):  
Female Students ◽  
Rank Test ◽  
Research Subjects ◽  
Dating Relationships ◽  
Empathy Training ◽  
Before And After ◽  
The Mean ◽  
Victims Of Violence ◽  
Experimental Group ◽  
Wilcoxon Rank Test

AbstractThis study aims to determine the effect of empathy training to improve forgiveness for female students who are victims of violence in dating relationships. Research subjects were 5 female students who were victims of violence in dating relationships. This study was only an experimental group, taken from the results of the pre-test on the empathy and forgiveness scale in the low and medium categories and interviews. The research design used was the experimental design of one group group pretest-posttest design. Data collection tools used in the form of empathy, forgiveness, observation and interviews. Analysis of the data used is the Wilcoxon Rank Test to see the difference in experimental group scores between before and after treatment. The Wilcoxon Rank Test found that there was a difference in the forgiveness score in the experimental group after giving empathy with a Z = -2.023 with a significance of 0.043 (p <0.05) with the mean pre-test (X test = 36.40) lower than the mean post-test (X ̅ = 63.40). The conclusion of this study is that there are differences in forgiveness scores between before and after being given empathy training.

scholarly journals Role of transferrin in determining internal iron distribution

Blood ◽  
1977 ◽  
Vol 49 (6) ◽  
pp. 957-966
Author(s):  
P Pootrakul ◽  
A Christensen ◽  
B Josephson ◽  
CA Finch
Keyword(s):  
Isotope Ratio ◽  
Hepatic Uptake ◽  
The Other ◽  
Iron Salts ◽  
Iron Deficient ◽  
Loading And Unloading ◽  
The Mean

The behavior in vivo of transferrin in loading and unloading iron from its two sites was examined in rats. Radioiron entering the plasma from the gastrointestinal tract in iron-deficient, normal and iron-loaded rats did not differ in its subsequent tissue distribution between erythroid marrow and liver of normal recipients from a second isotope added to the same plasma in vitro. Loading studies in vitro were then carried out employing a reticulocyte incubation model designed to place one isotope predominantly on one site of transferrin, more available to the erythron, and the second isotope on the other site, more available to the liver. In 15 groups of animals in which 3 different iron salts were employed to load transferrin with iron, the mean isotope ratio in the erythron was 1.03 (+/-0.06 SD) and the mean liver ratio was 0.75 (+/-0.21 SD). It was found that the incubation of plasma with reticulocytes resulted in contamination of the plasma by radioactive hemoglobin. After allowance was made for hepatic uptake of radiohemoglobin in the 13 groups in which proper correction could be made, the isotope ratio in the liver became 0.97 (+/-0.17 SD). It is concluded that iron atoms from the two sites of transferrin have similar tissue distributions in vivo in the experimental situations examined.

scholarly journals Ternary vowel length in Shilluk

Phonology ◽  
2019 ◽  
Vol 36 (1) ◽  
pp. 91-125
Author(s):  
Bert Remijsen ◽  
Otto Gwado Ayoker ◽  
Signe Jørgensen
Keyword(s):  
Fundamental Frequency ◽  
The Other ◽  
Supporting Evidence ◽  
Vowel Duration ◽  
Vowel Quality ◽  
Vowel Length ◽  
Mean Values ◽  
Acoustic Study ◽  
The Mean

Ternary or three-level vowel length is typologically rare, and supporting evidence is limited. This paper presents the results of an investigation into the hypothesised case of this configuration in Shilluk. We first describe the role of vowel length in Shilluk phonology and morphology, and then report on an acoustic study in which minimal sets for vowel length (short, long, overlong) are measured for vowel duration, coda duration, vowel quality and fundamental frequency. Short, long and overlong vowels differ significantly and substantially in terms of vowel duration: 96% of the items can be classified successfully for vowel length on the basis of this measurement alone. Of the other measurements, only vowel quality is significant, and this effect is considerably smaller. The mean values for vowel duration – 68, 111 and 150 ms for short, long and overlong vowels respectively – are similar to those reported for ternary vowel length in Dinka.

scholarly journals Promoting Hand Sanitizer Use in a University Cafeteria

2020 ◽  
Vol 29 (1) ◽  
pp. 255-263 ◽  
Author(s):  
Christoph Bördlein
Keyword(s):  
Efficient Method ◽  
Control Site ◽  
The Other ◽  
Response Effort ◽  
Public Places ◽  
Hand Sanitizer ◽  
Considerable Impact ◽  
The Mean ◽  
Cost Efficient

AbstractHandwashing is the most cost-efficient method to lower the risk of the transmission of infectious diseases. Especially before eating in public places like cafeterias, handwashing is recommended. Often, people do not wash their hands before eating because of the response effort associated with going to the bathroom. As an alternative way to improve hygiene, disinfection with a hand sanitizer gel is recommended. The current study used an A-B-C-A design (and a no-intervention control site) with prompts and feedback to increase the number of cafeteria patrons using hand sanitizer. Dispensers for hand sanitizer gel were placed at the entrance area of two halls of a university cafeteria. Intervention took place in one hall, whereas the other served as a control. After baseline, a poster explaining the usefulness of hand sanitizing was posted near the entrance of the cafeteria. This led to a doubling of the percentage of cafeteria patrons using the hand sanitizer, from 10.79% during baseline to 24.45%. A second poster provided feedback about the percentage of patrons sanitizing their hands and asked for more participation. This led to no further increases in hand sanitizing (23.73%). After all posters were removed, the percentage dropped to 15.63% in the mean. This research demonstrated that a simple, informative prompt can have a considerable impact on hand-sanitizing behavior. However, the role of feedback in such interventions remains questionable.

The Effect of Boundary Shape and Minima Selection on Single Limb Stance Postural Stability

2012 ◽  
Vol 28 (5) ◽  
pp. 608-615 ◽  
Author(s):  
Stephen C. Cobb ◽  
Mukta N. Joshi ◽  
David M. Bazett-Jones ◽  
Jennifer E. Earl-Boehm
Keyword(s):  
Postural Stability ◽  
Rank Correlation ◽  
Stability Limit ◽  
Rank Test ◽  
Test Results ◽  
Absolute Time ◽  
Boundary Shape ◽  
Eyes Closed ◽  
Eyes Open ◽  
The Mean

The effect of time-to-boundary minima selection and stability limit definition was investigated during eyes open and eyes closed condition single-limb stance postural stability. Anteroposterior and mediolateral time-to-boundary were computed using the mean and standard deviation (SD) of all time-to-boundary minima during a trial, and the mean and SD of only the 10 absolute time-to-boundary minima. Time-to-boundary with rectangular, trapezoidal, and multisegmented polygon defined stability limits were also calculated. Spearman’s rank correlation coefficient test results revealed significant medium-large correlations between anteroposterior and mediolateral time-to-boundary scores calculated using both the mean and SD of the 10 absolute time-to-boundary minima and of all the time-to-boundary minima. Friedman test results revealed significant mediolateral time-to-boundary differences between boundary shape definitions. Follow-up Wilcoxon signed rank test results revealed significant differences between the rectangular boundary shape and both the trapezoidal and multisegmented polygon shapes during the eyes open and eyes closed conditions when both the mean and the SD of the time-to-boundary minima were used to represent postural stability. Significant differences were also revealed between the trapezoidal and multisegmented polygon definitions during the eyes open condition when the SD of the time-to-boundary minima was used to represent postural stability. Based on these findings, the overall results (i.e., stable versus unstable participants or groups) of studies computing postural stability using different minima selection can be compared. With respect to boundary shape, the trapezoid or multisegmented polygon shapes may be more appropriate than the rectangular shape as they more closely represent the anatomical shape of the stance foot.

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