Comparison of Quantification Methods of111In-Labelled Platelet Deposition in Peripheral Bypass Grafts

1987 ◽  
Vol 26 (02) ◽  
pp. 87-92 ◽  
Author(s):  
A. Verbruggen ◽  
C. De Bakker ◽  
A. Vandecruys ◽  
J. Joosten ◽  
A. Nevelsteen ◽  
...  

The action of antithrombotic drugs can be evaluated by measuring the deposition of111In-labelled platelets on peripheral bypass grafts several days after injection. This evaluation can be performed qualitatively (visual interpretation on the daily images) or quantitatively. Four different methods which calculate the ratio of platelet uptake with a reference region are compared: two methods use a gamma camera and two a detector. A blood sample or the region under the sternal angle are used as reference. The daily ratio of the counts, recorded by a gamma camera in a region of interest covering the graft, and the blood radioactivity interpolated from a platelet survival curve appears to be the most reliable method. The information of all the ratios can be combined in a single thrombogenicity index which reflects the daily rise of a linear or exponential regression versus time.

1991 ◽  
Vol 260 (1) ◽  
pp. G13-G16 ◽  
Author(s):  
M. Proano ◽  
M. Camilleri ◽  
S. F. Phillips ◽  
G. M. Thomforde ◽  
M. L. Brown ◽  
...  

In five healthy male volunteers, we compared solid and liquid transit though the unprepared colon. 99mTc-diethylenetriaminepentaacetic acid in 10 ml saline was injected into the cecum through an orocecal tube at 1 ml/min immediately after a methacrylate-coated medication capsule was seen to deliver 111In-labeled Amberlite IR-120PLUS pellets (avg diam, 1.0 mm) into the cecum. Segmental transits through the ascending, transverse, descending, and rectosigmoid regions were determined using a dual gamma camera system and a variable region of interest program. There was no difference between solid [half time, 247 +/- 60 (SE) min] and liquid (312 +/- 88 min) emptying from the ascending colon. Colonic transit of solids and liquids was further compared by regional counts and stool outputs at 12 and 24 h. There were no significant differences between solids and liquids (P greater than 0.05). Our data suggest that transit through the unprepared human colon is not different for solids and small volumes of liquids, when these are delivered together to the ascending colon.


2019 ◽  
Vol 74 ◽  
pp. 137-145
Author(s):  
Francesca Donadoni ◽  
Mirko Bonfanti ◽  
Cesar Pichardo-Almarza ◽  
Shervanthi Homer-Vanniasinkam ◽  
Alan Dardik ◽  
...  

VASA ◽  
2010 ◽  
Vol 39 (2) ◽  
pp. 196-198 ◽  
Author(s):  
Magnetti ◽  
Thalhammer ◽  
Hechelhammer ◽  
Husmann ◽  
Pfammatter ◽  
...  

We report the case of a symptomatic spontaneous leak of a biosynthetic graft (Omniflow® II) treated endovascularly with a stentgraft. Potential degeneration of biosynthetic grafts with aneurysm formation is a well known problem with a reported incidence of up to 7 %. Implantation of a stentgraft for treatment of a pseudoaneurysm is a valuable treatment option in native arteries; however its use in Omniflow® II bypass grafts has not been reported so far. Surveillance of peripheral bypass grafts with duplex ultrasound may be helpful to detect morphological alterations of the graft.


Author(s):  
Amruthavakkula Shiva ◽  
Vignesh T. Sai ◽  
Subramaniyan V. Siva ◽  
Kumar T. Rajamani ◽  
Sankara Sai S. Siva

Thyroid uptake study is a technique that requires injection of a radio-isotope/radiotracer emitting gamma rays into the blood stream of the patient to study the functionality of thyroid in accordance to its uptake. The Gamma Camera uses a LEAP (Low Energy All Purpose) collimator which handles only photons emitted from radio-isotopes having lower emission energies. Technetium-99m is used whose energy of emission is around 140 keV. For a typical Thyroid Uptake Probe where Iodine-131 having greater emission energy of 364 keV is preferred, but existing Thyroid Uptake software is not feasible. Therefore an Interactive GUI (Graphical User Interface) tool was developed using Fiji for determination of tracer uptake by manually drawing the Region of Interest around left and right thyroid lobes separately. Developed tool was tested on 35 real time thyroid cases and the uptake values obtained are compared with those obtained from the existing software tool.


2006 ◽  
Vol 39 ◽  
pp. S375
Author(s):  
P.D. Devereux ◽  
T.P. O'Brien ◽  
M.T. Walsh ◽  
T.M. McGloughlin

Author(s):  
Ahmad Imam Rauyani ◽  
Muhammad Hamka Ibrahim ◽  
Subuh Pramono

Paper currency recognition is important for automatic payment system. The paper performs a nominal paper detection process using image processing with canny method implemented in python programming language. The canny method is used to find edge features in the nominal currency. By using template matching of image reference, region of interest (ROI) of nominal value is extracted so that it can be used in any orientation of  paper currency image. The ROI of nominal image is processed by canny edge method and spatial transformation to strengthen the image features and being processed by template matching to decide nominal currency. The study has successfully tested nominal value of 1000, 2000, 5000, 10000, 20000, 50000, and 100000 Indonesia banknotes which then the currency value will appear in the value variable in python.


2000 ◽  
Vol 11 (4) ◽  
pp. 445-452 ◽  
Author(s):  
David E. Lee ◽  
David L. Waldman ◽  
Roy K. Sumida ◽  
Richard M. Green

Author(s):  
Marco Bucci ◽  
Irina Savitcheva ◽  
Gill Farrar ◽  
Gemma Salvadó ◽  
Lyduine Collij ◽  
...  

Abstract Background [18F]flutemetamol PET scanning provides information on brain amyloid load and has been approved for routine clinical use based upon visual interpretation as either negative (equating to none or sparse amyloid plaques) or amyloid positive (equating to moderate or frequent plaques). Quantitation is however fundamental to the practice of nuclear medicine and hence can be used to supplement amyloid reading methodology especially in unclear cases. Methods A total of 2770 [18F]flutemetamol images were collected from 3 clinical studies and 6 research cohorts with available visual reading of [18F]flutemetamol and quantitative analysis of images. These were assessed further to examine both the discordance and concordance between visual and quantitative imaging primarily using thresholds robustly established using pathology as the standard of truth. Scans covered a wide range of cases (i.e. from cognitively unimpaired subjects to patients attending the memory clinics). Methods of quantifying amyloid ranged from using CE/510K cleared marked software (e.g. CortexID, Brass), to other research-based methods (e.g. PMOD, CapAIBL). Additionally, the clinical follow-up of two types of discordance between visual and quantitation (V+Q- and V-Q+) was examined with competing risk regression analysis to assess possible differences in prediction for progression to Alzheimer’s disease (AD) and other diagnoses (OD). Results Weighted mean concordance between visual and quantitation using the autopsy-derived threshold was 94% using pons as the reference region. Concordance from a sensitivity analysis which assessed the maximum agreement for each cohort using a range of cut-off values was also estimated at approximately 96% (weighted mean). Agreement was generally higher in clinical cases compared to research cases. V-Q+ discordant cases were 11% more likely to progress to AD than V+Q- for the SUVr with pons as reference region. Conclusions Quantitation of amyloid PET shows a high agreement vs binary visual reading and also allows for a continuous measure that, in conjunction with possible discordant analysis, could be used in the future to identify possible earlier pathological deposition as well as monitor disease progression and treatment effectiveness.


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