Changes Of Plasma Thromboxane B22 And Cyclic Nucleotides At Exercise Test In Patients Of Coronary Heart Disease

1981 ◽  
Author(s):  
F Numano ◽  
M Yajima ◽  
T Hosaka ◽  
K Nishiyama ◽  
K Shimokado ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Treadmill Exercise ◽  
Poor Response ◽  
Vascular Wall ◽  
Treadmill Test ◽  
Haemodynamic Change ◽  
Previous Level ◽  
High Level ◽  
Camp And Cgmp

To search the response of vascular wall at exercise, submaximal treadmill test was performed in 30 patients with the complaint of chest pain and plasma thromboxane B2(TXB2), cyclic AMP(cAMP) and cyclic GMP(cGMP) levels were measured before, immediately and 30 minutes after the test by radioimmunoassay. Using Hollenberg’s treadmill exercise score modified by us. 15 patients were judged as “positive” (P- group) and others as “negative” (N-group). Plasma levels of TXB2 in P-group were 262.4 ± 30.9 pg/ml, a statistically high level as compared with 186.7 ± 17.5 in N-group. In N-group no changes of plasma TXB2 levels were recognized after exercise. However, in P-group this level revealed a statistically significant decrease immediately after exercise and restored to the previous level 30 minutes after exercise. Although there were high levels of both cAMP and cGMP in N-group (cAMP: 11.9 ± 1.0 pmoles/ml; cGMP: 3.1 ± 0.5), as compared with these in P-group (10.9 ± 1.5, 2.6 ± 0.5), the significance was not statistical. However, in N-group levels of cAMP and cGMP increased significantly immediately after exercise and restored to the levels before test. On the other hand, no significant changes of these levels were found in P-group. These data may suggest that the poor response of vascular wall for haemodynamic change exists in patients of coronary heart disease which breaks the exquisite balance of the interrelationship between platelets and vascular wall.

Multiple Lead Ecg Submaximal Treadmill Exercise Tests in Angiographically Documented Coronary Heart Disease

Angiology ◽  
1976 ◽  
Vol 27 (3) ◽  
pp. 149-156 ◽  
Author(s):  
Stanley C. Tucker ◽  
V. Eric Kemp ◽  
William E. Holland ◽  
John H. Horgan
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Treadmill Exercise ◽  
Exercise Tests

scholarly journals LDL-C/HDL-C and carotid plaques in patients with coronary heart disease: A Chinese cohort study

2021 ◽  
Author(s):  
Zhu Li ◽  
Qi Cheng ◽  
Yijia Liu ◽  
Xufeng Cheng ◽  
Shuo Wang ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Large Scale ◽  
Healthy Lifestyle ◽  
Density Lipoprotein ◽  
Estimating Equation ◽  
Carotid Plaques ◽  
Cholesterol Ratio ◽  
Beneficial Effects ◽  
High Level

Abstract Background: Evidence of the association the low-/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) with the carotid plaques remains limited. The purpose of this study is to examine the association between LDL-C/HDL-C and carotid plaques of coronary heart disease (CHD), and to study what extent a healthy lifestyle reduces the risk of carotid plaques.Methods: In this large-scale and multi-center retrospective study, a total of 9,426 participants to explore the association between LDL-C/HDL-C and carotid plaques. No smoking and no drinking were considered healthy lifestyle. Generalised estimating equation models and conditional logistic regressions were used in statistical analyses.Results: In all the 9,426 participants, there were 6,989 (74.15%) patients having identified carotid plaques. High levels of LDL-C/HDL-C had a higher risk of carotid plaques than other lipid variables (OR:1.63; 95%CI:1.43-1.86). In stratified analyses by LDL-C/HDL-C triplet, participants in the LDL-C/HDL-C (＞3mmol/L) group had a higher risk of carotid plaques compared to other two groups. Compared with the unfavourable lifestyle, intermediate lifestyle or favourable lifestyle was associated with a significant 30% or 67% decrease in carotid plaques risk among patients with the LDL-C/HDL-C(＞3mmol/L) respectively. There were significantly additive and multiplicative interactions between lifestyle and LDL-C/HDL-C on carotid plaques.Conclusion: Our findings provide evidence that a high level of LDL-C/HDL-C can increase the risk of carotid plaques in patients with CHD. And adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques.

scholarly journals ECG DISPERSION MAPPING PARAMETERS DURING THE TREADMILL TEST IN PATIENTS WITH CORONARY HEART DISEASE

2013 ◽  
Vol 12 (2) ◽  
pp. 41-45
Author(s):  
G. G. Ivanov ◽  
E. V. Agafoshina ◽  
A. A. Pecherskikh ◽  
G. Khalabi
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Complex Analysis ◽  
Stress Test ◽  
Signs And Symptoms ◽  
Physical Stress ◽  
Functional Class ◽  
Control Group ◽  
Physiological Status ◽  
Treadmill Test

Aim.The aim of the study was the complex analysis of the ECG-12 and ECG dispersion mapping (DM) parameters during the physical stress test in patients with coronary heart disease (CHD).Material and methods.The main group included 143 CHD patients with Functional Class I–III angina (99 men and 44 women; mean age 50,6±4,6 years). The control group included 37 healthy individuals (mean age 44,3±4,8 years). Patients with heart failure signs and symptoms were excluded. All participants underwent the graduated physical stress test.Results.Two variants of the ECG changes were observed, with normal and abnormal reaction of ECG DM parameters. The latter group was characterised by the following: ratio of heart rate and myocardial micro-alternation index (HRmax/MMImax) 30% at the peak HR.Conclusion.Using the ECG DM method during the treadmill test is a feasible and useful approach to gain additional diagnostic information on the myocardial electro-physiological status and, therefore, to select the patients who need further examination and treatment. 

scholarly journals Addition of Risk Factors of Coronary Heart Disease in Diagnostic Value of Treadmill Score for Detecting Complexity of Coronary Arterial Lesions

2018 ◽  
Vol 4 (2) ◽  
pp. 88
Author(s):  
Mariyetty K.S. Nasution ◽  
Abdullah A. Siregar ◽  
Harris Hasan ◽  
Zulfikri Mukhtar ◽  
Abdul H. Raynaldo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Stable Angina ◽  
Diagnostic Value ◽  
Coronary Artery Lesions ◽  
Treadmill Test ◽  
Chd Risk ◽  
Chd Risk Factors

Background: Coronary heart disease (CHD) is still the leading cause of death in the world. There are various risk factors for atherosclerosis leading to CHD. Duke Treadmill Score (DTS) is known to demonstrate prognostic stratification and has a diagnostic value in predicting the number of coronary arteries involved in patient populations with ischemic heart disease. However, DTS does not describe the role of risk factors for coronary heart disease to the complexity of coronary artery lesions. This study aims to add risk factors for coronary heart disease on DTS to detect the complexity of coronary artery lesions with stable angina pectoris.Methods: This study was a cross-sectional study in stable angina pectoris patient who comes to Haji Adam Malik Hospital Medan from January 2017 until February 2018. Patients who have done treadmill test and coronary angiography, and fulfill inclusion and exclusion criteria are included in the study. ECG examination and recording of risk factors for coronary heart disease were done. DTS assessment was performed based on a treadmill test and Syntax score based on coronary angiography results. Diagnostic tests were performed to assess the sensitivity and specificity of the addition of CHD risk factors to detect the complexity of coronary artery lesions.Results: Of the 76 people with stable angina pectoris, 55 people were found with low SYNTAX and 21 people with high Syntax. DTS is divided into 3 groups: mild (> -10), moderate (-10 to - 13.5), and severe (≤-13.6) based on the cut off of the ROC curve. Risk factors for CHD are divided into 3 groups, mild (≤3 CHD risk factors), moderate (4-6 CHD risk factors), and severe (7 CHD risk factors) based on the cut off of the ROC curve, then assessed the relationship with Syntax which has been divided into 2 groups, low Syntax, and high Syntax. Diagnostic test shows the addition of risk factors of CHD to DTS to detect the complexity of coronary artery lesions have greater sensitivity and specificity than DTS without the addition of risk factors of CHD, 95%, and 89%.Conclusion: The addition of risk factors for coronary heart disease on DTS can detect the complexity of coronary artery lesions.

scholarly journals Clinically Classified Periodontitis and Its Association in Patients with Preexisting Coronary Heart Disease

2013 ◽  
Vol 2013 ◽  
pp. 1-9
Author(s):  
Nikolaos A. Chrysanthakopoulos ◽  
Panagiotis A. Chrysanthakopoulos
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Multivariate Logistic Regression Analysis ◽  
Analysis Model ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Related Information ◽  
Probing Pocket Depth ◽  
Health Related ◽  
High Level

The aim of this retrospective study was to investigate possible associations between clinically classified periodontitis as determined by assessing its severity and diagnosed coronary heart disease in outpatients referred to a specialist clinic for neurosurgery treatment. A total of 2,912 individuals were clinically examined for periodontal disease experience by using probing pocket depth (PPD) and clinical attachment loss (CAL). Socioeconomic, oral health behaviour, and general health related information was collected by using a self-administered questionnaire. Statistical analysis of the questionnaire items was performed by using multivariate logistic regression analysis model. The results showed that the occurrence of hypertension (OR=2.42, 95% CI = 1.52–3.84), smoking (OR=1.97, 95% CI = 1.25–3.11), classified periodontitis (OR=1.79, 95% CI = 1.15–2.77), and the high level of serum C-reactive protein (OR=1.74, 95% CI = 1.05–2.89) were significantly associated with the presence of coronary heart disease. These observations strengthen the role of some of the traditional causative risk factors for coronary heart disease while a significant association was recorded between diagnosed coronary heart disease and clinically classified periodontitis which is considered as a risk factor for coronary heart disease.

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