Tests for Platelet Changes, Acute Phase Reactants and Serum Lipids in Diabetes mellitus and Peripheral Vascular Disease

1982 ◽  
Vol 48 (03) ◽  
pp. 289-293 ◽  
Author(s):  
B A van Oost ◽  
B F E Veldhuyzen ◽  
H C van Houwelingen ◽  
A P M Timmermans ◽  
J J Sixma
Keyword(s):  
Diabetes Mellitus ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Acute Phase ◽  
Serum Lipids ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Acute Phase Reactants ◽  
Control Subjects ◽  
And Control

SummaryPlatelets tests, acute phase reactants and serum lipids were measured in patients with diabetes mellitus and patients with peripheral vascular disease. Patients frequently had abnormal platelet tests and significantly increased acute phase reactants and serum lipids, compared to young healthy control subjects. These differences were compared with multidiscriminant analysis. Patients could be separated in part from the control subjects with variables derived from the measurement of acute phase proteins and serum lipids. Platelet test results improved the separation between diabetics and control subjects, but not between patients with peripheral vascular disease and control subjects. Diabetic patients with severe retinopathy frequently had evidence of platelet activation. They also had increased acute phase reactants and serum lipids compared to diabetics with absent or nonproliferative retinopathy. In patients with peripheral vascular disease, only the fibrinogen concentration was related to the degree of vessel damage by arteriography.

scholarly journals Association of Micro and Macrovascular Complications with Fatty Liver in Patients with Type 2 Diabetes Mellitus

2014 ◽  
Vol 3 (1) ◽  
pp. 270 ◽  
Author(s):  
Vaddadi Suresh ◽  
N. S. R. C. Guptha ◽  
E. Usha Bhargavi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Fatty Liver ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Cardiac Disease ◽  
Macrovascular Complications ◽  
Diabetic Patients ◽  
Peripheral Vascular

<p><strong>Background</strong>: Fatty liver is a fairly common entity seen in the diabetic population. Studies showed that liver adiposity is independently associated with Insulin Resistance and can substantially increase the risk of various micro and macrovascular complications of diabetes mellitus.</p><p><strong>Aims:</strong> Identifying various micro and macrovascular complications and finding their association with fatty liver disease in type 2 diabetes patients.</p><p><strong>Material and Methods:</strong> 141 diabetic patients admitted in a tertiary care center over a two year period were screened for fatty liver by ultrasonography of the abdomen and were classified into FL (fatty Liver) group and NFL (non fatty liver) group. All patients were investigated for complications like nephropathy, neuropathy, retinopathy, cardiac and peripheral vascular disease. Statistical analysis was done to find the association of complications with fatty liver.</p><p><strong>Results:</strong> out of 141 patients, 49 (35%) had fatty liver. Leading complication was neuropathy (31.2%), followed by nephropathy (11.3%), retinopathy (10.6%), cardiac disease (9.2%) and peripheral vascular disease (3.55). Between FL and NFL groups, Diabetic neuropathy (40.8% vs. 23.9%) and cardiac disease (16.3% vs. 5.4%) showed statical significance (p&lt;0.05), while other complications were more or less equally prevalent in the two groups.</p><p><strong>Conclusions:</strong> Fatty liver is seen in one third of diabetic patients. vascular complications like neuropathy and cardiac disease are more commonly seen in diabetic patients with fatty liver than those without fatty liver.</p>

SERUM LIPIDS AND LIPOPROTEINS IN PERIPHERAL VASCULAR DISEASE

The Lancet ◽  
1971 ◽  
Vol 298 (7731) ◽  
pp. 947-950 ◽  
Author(s):  
RogerM. Greenhalgh ◽  
D.S. Rosengarten ◽  
Ivan Mervart ◽  
Barry Lewis ◽  
J.S. Calnan ◽  
...  
Keyword(s):  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Serum Lipids ◽  
Peripheral Vascular ◽  
Lipids And Lipoproteins

A Clinical Study of Bradilan (Tetranicotinoylfructose) in Diabetic Patients with Peripheral Vascular Disease

1975 ◽  
Vol 3 (1) ◽  
pp. 10-11 ◽  
Author(s):  
Cyril Boroda
Keyword(s):  
Adverse Effect ◽  
Clinical Study ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Diabetic Control ◽  
Diabetic Patients ◽  
Peripheral Vascular

Nineteen diabetic patients with peripheral vascular disease treated with Bradilan (tetranicotinoylfructose) tablets showed cure or improvement in 14 cases with no adverse effect on their diabetic control. It must therefore be considered a useful drug in the treatment of such diabetic patients with peripheral vascular problems.

Chiropody May Prevent Amputations in Diabetic Patients on Peritoneal Dialysis

2003 ◽  
Vol 23 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Jennifer Lipscombe ◽  
Sarbjit V. Jassal ◽  
Susan Bailey ◽  
Joanne M. Bargman ◽  
Stephen Vas ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Tertiary Care ◽  
Diabetic Patients ◽  
Care Hospital ◽  
Peripheral Vascular ◽  
Foot Care ◽  
Care Assessment ◽  
Patients With Diabetes

← Background A multidisciplinary approach has been shown to be of benefit in the prevention of lower limb ulceration and amputation in patients with diabetes, but there is less information on the role of such an approach in patients receiving dialysis treatment. ← Objective The purpose of the present study was to determine whether the institution of a chiropody program would result in fewer amputations in diabetic patients on peritoneal dialysis (PD). ← Design Retrospective chart review. ← Setting The PD program at a tertiary-care hospital. ← Patients Patients with diabetes that were enrolled in the PD program between January 1997 and December 1999, inclusive, that were offered the opportunity to see a chiropodist, and that agreed to be seen. A total of 132 patients were included. ← Intervention Education about foot care, assessment, and, in some instances, treatment by a chiropodist. ← Results Patients with an amputation were more likely to be male ( p < 0.01) and have peripheral vascular disease ( p < 0.001) compared to those without an amputation. They also had a lower average mean arterial pressure ( p < 0.05), lower weekly creatinine clearance ( p < 0.01), higher mean erythropoietin dose ( p < 0.05), and longer duration of end-stage renal disease ( p < 0.001). Factors that were predictive of shorter time to death or amputation were older age [hazard ratio (HR) = 1.03, p < 0.05], peripheral vascular disease (HR = 2.66, p < 0.01), and cerebrovascular disease (HR = 2.70, p < 0.01). Being seen by a chiropodist was protective (HR = 0.39, p < 0.01). ← Conclusion The current study suggests that a chiropody program may help to prevent amputation in patients with diabetes on PD.

Peripheral Vascular Disease in Diabetic Peritoneal Dialysis Patients

2007 ◽  
Vol 27 (2_suppl) ◽  
pp. 210-214 ◽  
Author(s):  
Heikki H.T. Saha ◽  
Yrjö K.J. Leskinen ◽  
Juha P. Salenius ◽  
Jorma T. Lahtela
Keyword(s):  
Peritoneal Dialysis ◽  
Vascular Disease ◽  
Peripheral Vascular Disease ◽  
Current Knowledge ◽  
Diabetic Patients ◽  
Peripheral Vascular ◽  
Dialysis Patients ◽  
Stage Renal Disease ◽  
End Stage ◽  
Review Current

In the present article, we review current knowledge of the epidemiology, diagnosis, and treatment of peripheral vascular disease in patients with end-stage renal disease. The main focus is placed on diabetic patients receiving peritoneal dialysis, but studies on patients receiving hemodialysis are also reviewed, because most reports involve this patient group, and the number of reports on peripheral vascular disease in PD patients alone is limited.

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