scholarly journals Oxidative and Antioxidative Stress Markers in Relation to Left Ventricular Dysfunction and Gender

2018 ◽  
Vol 03 (01) ◽  
pp. 006-011
Author(s):  
Indrani Garre ◽  
Raju Nallagasu ◽  
Malleshwar Rao Dangati ◽  
Indumathi Bobbala ◽  
Ravikiran Muddada
Keyword(s):  
Oxidative Stress ◽  
Left Ventricular Dysfunction ◽  
Ventricular Dysfunction ◽  
Coronary Intervention ◽  
Left Ventricular ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Difference ◽  
Antioxidative Stress ◽  
And Gender

Abstract Objective The aim of this study was to investigate the relationship between oxidative and antioxidative stress markers with presence of left ventricular dysfunction (LVD) and the severity of LVD with coronary artery disease (CAD) in patients who have undergone percutaneous coronary intervention (PCI). Further, the role of oxidative and anti-oxidative stress markers on gender was also investigated. Methods This was an observational prospective pilot study of patients diagnosed with CAD with LVD who underwent PCI at the center from June 2017 to December 2017. Based on the ejection function (EF), patients were categorized into three groups: mild (> 40–50%), moderate (> 35–40%), and severe (≤ 35%). The oxidative and antioxidative stress markers (malondialdehyde [MDA], glutathione [GSH], and nitric oxide [NO]) were studied and compared in these groups and in both genders as subanalysis. Results Total 33 patients were enrolled, of whom 23 were male (69.7%) and 10 were female (30.3%). Mean age of the study population was 58.8 ± 9.3 years. Significant elevation of MDA and NO was seen in 33 (100%) and 26 (78.8%), respectively, and decreased GSH was seen in 30 (90.9%). There was no significant difference with respect to oxidative and antioxidative stress markers and severity of LVD (MDA, p = 0.25; NO, p = 0.79; and GSH, p = 0.2) despite elevated MDA levels in all patients. The subanalysis was done to see the gender effect with oxidative and antioxidative stress markers (MDA, p = 0.29; NO, p = 0.10; and GSH, p = 0.50), and they all were insignificant. Conclusion In this study, there was no significant relationship of oxidative and anti-oxidative stress markers on the degree of LVD even though the elevated MDA levels suggestive of increased oxidative stress were seen in all patients. The further analysis of gender in relation to oxidative and antioxidative stress markers was also insignificant.

The association between irisin levels, element distribution and oxidative stress markers in adolescent swimmers

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Muaz Belviranli ◽  
Nilsel Okudan ◽  
Nuran Karakuyu
Keyword(s):  
Oxidative Stress ◽  
Exercise Training ◽  
Venous Blood ◽  
Element Distribution ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Difference ◽  
And Gender ◽  
Antioxidant Effects ◽  
And Oxidative Stress

Abstract The objective of this investigation was to compare irisin concentration and its relation with oxidative stress markers, antioxidant enzymes and element levels in both male adolescent swimmers and sedentary controls. Twelve male swimmers aged between 11 and 18 years, who performed regular swimming training for at least 2 years and 12 age- and gender-matched sedentary controls participated in this study. After anthropometric measurements were performed, fasting venous blood samples were taken at rest. Irisin, malondialdehyde (MDA) as a marker of oxidative stress, superoxide dismutase (SOD) as a marker of antioxidant enzyme and elements (Zn, Cu, Se, Cr, Ni, Al, Fe) were analyzed in these samples. MDA levels were lower but Zn levels and Zn/Cu ratio were higher in the swimmers than in sedentary controls (p < 0.05). There was no statistically significant difference in the irisin levels and SOD activities between the groups (p > 0.05). The results of the current study suggested that exercise training has antioxidant effects and may reduce oxidative damage. Exercise training has also limited effects on irisin levels in the adolescents.

Abstract 1378: NFkb Blockade Attenuate Cytokines And Oxidative Stress In The Paraventricular Nucleus And Decreases Neurohumoral Excitation In Spontaneously Hypertensive Rats

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Nithya Mariappan ◽  
Carrie Elks ◽  
Masudul Haque ◽  
Philip J Ebnezer ◽  
Elizabeth McIIwain ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Paraventricular Nucleus ◽  
Spontaneously Hypertensive Rats ◽  
Left Ventricular ◽  
Oxidative Stress Markers ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Stress Markers ◽  
And Oxidative Stress

The transcriptional factor, nuclear factor kappa B (NFkB) plays an important role in the regulation of cytokines. Among the cytokines, tumor necrosis factor-alpha (TNF) plays an important role in cardiovascular pathophysiology. This study was done to determine whether TNF-α blockade with etanercept (ETN) or NFkB blockade with dithiol pyrolidine thiocarbamate (PDTC) attenuate oxidative stress in the paraventricular nucleus (PVN) and contribute to neurohumoral excitation in spontaneously hypertensive rats. Method: Male 20 week old SHR rats were treated with ETN (1 mg/kg BW, sc) or PDTC (100mg/kg BW, ip) for 5 week period. Left ventricular function was measured at baseline (20 weeks) and at 25 weeks using echocardiography. Blood pressure was measured at weekly intervals throughout the study. At the end of the protocol rats were sacrificed the PVN was microdissected for the measurement of cytokines, oxidative stress markers using real time PCR (fold increase compared to WKY controls) and by immunohistochemistry. Superoxide, total reactive oxygen species and peroxynitrite were measured in the PVN and LV using electron paramagnetic resonance. Plasma norepinephrine and epinephrine an indicator of neurohumoral excitation was measured using HPLC-EC. Results: PVN data are tabulated. SHR animals had increased expression of protein and mRNA for cytokines and oxidative stress markers in the PVN and LV with increased MAP and cardiac hypertrophy when compared to WKY rats. Treatment with ETN and PDTC attenuated these increases with PDTC showing marked effect than ETN on hypertrophy and blood pressure responses. Conclusion: These findings suggest that cytokine activation in the PVN contributes to increased oxidative stress and neurohumoral excitation in hypertension.

scholarly journals Effect of Ticagrerol versus Clopidogrel on Oxidative Stress Bio-markers in Patients with Chronic Stable Angina after Percutaneous Coronary Intervention

2017 ◽  
Vol 12 (1) ◽  
pp. 26-30
Author(s):  
Elora Sharmin ◽  
Jasmine Fauzia Dewan ◽  
Syed Ali Ahsan ◽  
Harisul Hoque ◽  
Sheikh Foyez Ahmed ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Percutaneous Coronary Intervention ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Coronary Intervention ◽  
P2y12 Receptor ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Percutaneous Coronary

Background: Ischemic heart disease remains the leading cause of death in both developed and under developed countries. The use of antiplatelet drugs specifically the thienopyridine has become a standard for the treatment of acute coronary syndrome. These drugs irreversibly inhibit the platelet aggregation by blocking the P2Y12 receptor. But currently this therapeutic choice has become limited due to potential interaction with other drugs, slow hepatic conversion, genetic resistance and narrow therapeutic safety margin. Ticagrerol, a reversible P2Y12 receptor inhibitor may represent a significant advancement over currently available oral antiplatelet drugs.Objectives: The study was intended to compare the effect of Ticagrelor and Clopidogrel on oxidative stress markers in patients of chronic stable angina (CSA) following percutaneous coronary intervention (PCI).Materials & Methods: The present prospective observational study was carried out in the Department of Pharmacology, Cardiology and Microbiology, BSMMU, Dhaka from September 2014 to February 2016. The study included a total of 100 CSA patients. Patients were divided into two groups, Ticagrelor and Clopidogrel treated groups (each having 50 patients). The baseline laboratory parameters-Malondihyde (MDA), Reduced glutathione (GSH), bleeding time, clotting time and platelet count, were measured and then patients of both groups underwent PCI. The same parameters were again assessed at follow up after 4 weeks of intervention. Total 12 patients from Ticagrelor and 14 patients from Clopidogrel groups were dropped out. Comparisons of the laboratory parameters were made between two groups at baseline and at follow up and also within group before and after intervention.Result: In the present study at baseline characteristics of patients treated with ticagrelor and clopidogrel were almost identical in terms of age, sex, diabetes and hypertension. The level of plasma MDA in ticagrelor group was significantly reduced from baseline to follow up(4.5 ± 1.8 to 1.4 ± 0.7, p <0.001) and in clopidogrel group (4.2 ± 1.2 to 1.3 ± 0.7, p <0.001). GSH level was increased from 0.7 mg/dl to 2.5 mg/dl (p <0.001) in ticagrerol group and in clopidogrel group 0.6 mg/dl to 1.4 mg/dl, p <0.001).Conclusion: The study concluded that both ticagrelor and clopidogrel are similar effect on oxidative stress markers, resulting from oxidative injury processes in patients of chronic stable angina.University Heart Journal Vol. 12, No. 1, January 2016; 26-30

scholarly journals Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
V. Ramirez-Ramirez ◽  
M. A. Macias-Islas ◽  
G. G. Ortiz ◽  
F. Pacheco-Moises ◽  
E. D. Torres-Sanchez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Multiple Sclerosis ◽  
Fish Oil ◽  
Tissue Injury ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Fish Oil Supplementation

Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system. Oxidative stress is also thought to promote tissue damage in multiple sclerosis. Current research findings suggest that omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapenta-enoic acid (EPA) and docosahexaenoic acid (DHA) contained in fish oil may have anti-inflammatory, antioxidant, and neuroprotective effects. The aim of the present work was to evaluate the efficacy of fish oil supplementation on serum proinflammatory cytokine levels, oxidative stress markers, and disease progression in MS. 50 patients with relapsing-remitting MS were enrolled. The experimental group received orally 4 g/day of fish oil for 12 months. The primary outcome was serum TNFαlevels; secondary outcomes were IL-1β1b, IL-6, nitric oxide catabolites, lipoperoxides, progression on the expanded disability status scale (EDSS), and annualized relapses rate (ARR). Fish oil treatment decreased the serum levels of TNFα, IL-1β, IL-6, and nitric oxide metabolites compared with placebo group (P≤0.001). There was no significant difference in serum lipoperoxide levels during the study. No differences in EDSS and ARR were found.Conclusion.Fish oil supplementation is highly effective in reducing the levels of cytokines and nitric oxide catabolites in patients with relapsing-remitting MS.

scholarly journals Abnormal Levels of Inflammatory and Oxidative Stress Markers in Patients with Arterial Hypertension and Diabetes Mellitus

2013 ◽  
Vol 6 (2) ◽  
pp. 89-93
Author(s):  
Maya P. Danovska ◽  
Margarita L. Alexandrova ◽  
Irena I. Gencheva
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference ◽  
Traditional Risk Factors ◽  
And Oxidative Stress

Summary Individuals with hypertension and diabetes mellitus are at high risk of cerebrovascular and cardiovascular morbidity and mortality. Recent advances in the multifactorial pathophysiology of atherogenesis provide important information about the complex interrelations between traditional risk factors, inflammation and oxidative stress in mediating all stages of atherosclerosis. The objective of the study was to determine if some inflammatory and oxidative stress markers in patients with arterial hypertension and diabetes mellitus differ from those in healthy age-matched controls. Our results revealed a significant difference in blood pro/antioxidant activities in hypertensive diabetics and the controls. The investigation of inflammatory and oxidative stress markers along with traditional risk factors proves useful in complex assessment of vascular risk and primary prophylaxis of cerebrovascular and cardiovascular events.

scholarly journals Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers

2010 ◽  
Vol 4 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Cathy Tkaczyk ◽  
Alain Petit ◽  
John Antoniou ◽  
David J Zukor ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Biological Effects ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Metal On Metal ◽  
Significant Difference

It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.

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