scholarly journals Efficacy of Fish Oil on Serum of TNFα, IL-1β, and IL-6 Oxidative Stress Markers in Multiple Sclerosis Treated with Interferon Beta-1b

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
V. Ramirez-Ramirez ◽  
M. A. Macias-Islas ◽  
G. G. Ortiz ◽  
F. Pacheco-Moises ◽  
E. D. Torres-Sanchez ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Multiple Sclerosis ◽  
Fish Oil ◽  
Tissue Injury ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Fish Oil Supplementation

Multiple sclerosis (MS) is a chronic inflammatory disease, which leads to focal plaques of demyelination and tissue injury in the central nervous system. Oxidative stress is also thought to promote tissue damage in multiple sclerosis. Current research findings suggest that omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapenta-enoic acid (EPA) and docosahexaenoic acid (DHA) contained in fish oil may have anti-inflammatory, antioxidant, and neuroprotective effects. The aim of the present work was to evaluate the efficacy of fish oil supplementation on serum proinflammatory cytokine levels, oxidative stress markers, and disease progression in MS. 50 patients with relapsing-remitting MS were enrolled. The experimental group received orally 4 g/day of fish oil for 12 months. The primary outcome was serum TNFαlevels; secondary outcomes were IL-1β1b, IL-6, nitric oxide catabolites, lipoperoxides, progression on the expanded disability status scale (EDSS), and annualized relapses rate (ARR). Fish oil treatment decreased the serum levels of TNFα, IL-1β, IL-6, and nitric oxide metabolites compared with placebo group (P≤0.001). There was no significant difference in serum lipoperoxide levels during the study. No differences in EDSS and ARR were found.Conclusion.Fish oil supplementation is highly effective in reducing the levels of cytokines and nitric oxide catabolites in patients with relapsing-remitting MS.

scholarly journals Effect of fish oil on oxidative stress markers in patients with probable Alzheimer´s disease

2020 ◽  
Vol 70 (2) ◽  
pp. 123-133
Author(s):  
Lorenzo Sánchez-Romero ◽  
Fermín P. Pacheco-Moisés ◽  
El Hafidi Mohammed ◽  
Mario A. Mireles-Ramírez ◽  
José A. Cruz-Serrano ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Fish Oil ◽  
Membrane Fluidity ◽  
Oxidative Stress Markers ◽  
Omega 3 ◽  
Estrés Oxidativo ◽  
Stress Markers ◽  
Omega 6 ◽  
Óxido Nítrico

High intake of omega-3 fatty acids has been associated with synaptic plasticity, neurogenesis and memory in several experimental models. To assess the efficacy of fish oil supplementation on oxidative stress markers in patients diagnosed with probable Alzheimer´s disease (AD) we conducted a double blind, randomized, placebo controlled clinical trial. AD patients who met the inclusive criteria were given fish oil (containing 0.45 g eicosapentaenoic acid and 1 g docosahexaenoic acid) or placebo daily for 12 months. Oxidative stress markers [lipoperoxides, nitric oxide catabolites levels, oxidized/reduced glutathione ratio, and membrane fluidity] and fatty acid profile in erythrocytes were assessed at enrollment, and 6 and 12 months after the start of the testing period. At the end of the trial, in patients who received fish oil, we detected a decrease in the omega 6/omega 3 ratio in erythrocyte membrane phospholipids. This change was parallel with decreases in plasma levels of lipoperoxides and nitric oxide catabolites. Conversely, the ratio of reduced to oxidized glutathione was significantly increased. In addition, membrane fluidity was increased significantly in plasma membrane samples. In conclusion fish oil administration has a beneficial effect in decreasing the levels of oxidative stress markers and improving the membrane fluidity in plasma. El alto consumo de ácidos grasos omega-3 se asocia con la plasticidad sináptica, neurogénesis y memoria en varios modelos experimentales. Para evaluar la eficacia de la suplementación con aceite de pescado en los marcadores de estrés oxidativo en pacientes con diagnóstico de la enfermedad de Alzheimer (EA) probable realizamos un ensayo clínico doble ciego, aleatorizado, controlado con placebo. A los pacientes con la EA que cumplían los criterios de inclusión se les administró aceite de pescado (que contenía 0,45 g de ácido eicosapentaenoico y 1 g de ácido docosahexaenoico) o placebo diariamente durante 12 meses. Los marcadores de estrés oxidativo plasmático [niveles de lipoperóxidos y catabolitos del óxido nítrico, cociente de glutatión reducido a glutatiónoxidado) y fluidez de la membrana] y el perfil de ácidos grasos en los eritrocitos se evaluaron al inicio, 6 meses y alos 12 meses. Al final del ensayo, en pacientes que recibieron aceite de pescado detectamos una disminución en el cociente de ácidos grasos omega 6/omega 3 en los fosfolípidos de la membrana eritrocitaria. Este cambio ocurrió en paralelo a la disminución de los niveles plasmáticos de lipoperóxidos y catabolitos del óxido nítrico. Por el contrario, el cociente de glutatión reducido a glutatión oxidado se incrementó significativamente. Además, la fluidez de la membrana aumentó significativamente en las muestras analizadas. En conclusión, la administración de aceite de pescado tiene un efecto beneficioso al disminuir los niveles de marcadores de estrés oxidativo plasmático y mejorar la fluidez de la membrana plasmática.

Efficacy of Melatonin on Serum Pro-inflammatory Cytokines and Oxidative Stress Markers in Relapsing Remitting Multiple Sclerosis

2018 ◽  
Vol 49 (6) ◽  
pp. 391-398 ◽  
Author(s):  
Angélica L. Sánchez-López ◽  
Genaro Gabriel Ortiz ◽  
Fermín P. Pacheco-Moises ◽  
Mario A. Mireles-Ramírez ◽  
Oscar K. Bitzer-Quintero ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Inflammatory Cytokines ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis ◽  
And Oxidative Stress ◽  
Pro Inflammatory Cytokines

scholarly journals Oxidative Stress is Increased in Serum from Mexican Patients with Relapsing-Remitting Multiple Sclerosis

2009 ◽  
Vol 26 (1) ◽  
pp. 35-39 ◽  
Author(s):  
Genaro Gabriel Ortiz ◽  
Miguel Ángel Macías-Islas ◽  
Fermín P. Pacheco-Moisés ◽  
José A. Cruz-Ramos ◽  
Silvia Sustersik ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Healthy Controls ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Mcdonald Criteria ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Nitric Oxide Metabolites ◽  
Relapsing Remitting Multiple Sclerosis

Objective: To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis.Methods: Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification.Results: Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.

scholarly journals Associations between vitamin E, oxidative stress markers, total homocysteine levels, and physical activity or cognitive capacity in older adults

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ahmad H. Alghadir ◽  
Sami A. Gabr ◽  
Shahnawaz Anwer ◽  
Heng Li
Keyword(s):  
Oxidative Stress ◽  
Physical Activity ◽  
Nitric Oxide ◽  
Older Adults ◽  
Vitamin E ◽  
Cognitive Capacity ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Total Antioxidant ◽  
Total Homocysteine

AbstractThis study examined the associations between vitamin E, oxidative stress markers, total homocysteine levels, and physical activity or cognitive capacity in older adults. One hundred and six older adults (62 men, 44 women) within the age range of 56–81 years participated. The Global Physical Activity Questionnaire and the Loewenstein Occupational Therapy Cognitive Assessment were used to assess physical activity and cognitive function, respectively. Vitamin E (e.g., α-tocopherol and γ-tocopherol), oxidative stress markers (e.g., total antioxidant capacity and nitric oxide), and total homocysteine were estimated. There were significant associations between physical activity (high versus moderate versus poor) and all biomarkers (all p = 0.000, and p = 0.010 for γ-tocopherol). While total homocysteine and total antioxidant capacity were significantly associated with cognitive capacity (p = 0.000), vitamin E levels (e.g., α-tocopherol and γ-tocopherol) and nitric oxide (p = 0.354, 0.103 and 0.060, respectively) were not related to cognitive capacity in older adults. This study concludes that physical activity was associated with Vitamin E, oxidative stress markers, total homocysteine, and cognitive capacity in older adults. Although cognitive capacity was associated with total homocysteine and total antioxidant capacity, it was unrelated to vitamin E levels and nitric oxide in older adults.

scholarly journals Abnormal Levels of Inflammatory and Oxidative Stress Markers in Patients with Arterial Hypertension and Diabetes Mellitus

2013 ◽  
Vol 6 (2) ◽  
pp. 89-93
Author(s):  
Maya P. Danovska ◽  
Margarita L. Alexandrova ◽  
Irena I. Gencheva
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Risk Factors ◽  
Arterial Hypertension ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Cardiovascular Morbidity And Mortality ◽  
Significant Difference ◽  
Traditional Risk Factors ◽  
And Oxidative Stress

Summary Individuals with hypertension and diabetes mellitus are at high risk of cerebrovascular and cardiovascular morbidity and mortality. Recent advances in the multifactorial pathophysiology of atherogenesis provide important information about the complex interrelations between traditional risk factors, inflammation and oxidative stress in mediating all stages of atherosclerosis. The objective of the study was to determine if some inflammatory and oxidative stress markers in patients with arterial hypertension and diabetes mellitus differ from those in healthy age-matched controls. Our results revealed a significant difference in blood pro/antioxidant activities in hypertensive diabetics and the controls. The investigation of inflammatory and oxidative stress markers along with traditional risk factors proves useful in complex assessment of vascular risk and primary prophylaxis of cerebrovascular and cardiovascular events.

scholarly journals Significance of Elevated Blood Metal Ion Levels in Patients with Metal-on-Metal Prostheses: An Evaluation of Oxidative Stress Markers

2010 ◽  
Vol 4 (1) ◽  
pp. 221-227 ◽  
Author(s):  
Cathy Tkaczyk ◽  
Alain Petit ◽  
John Antoniou ◽  
David J Zukor ◽  
Maryam Tabrizian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metal Ion ◽  
Biological Effects ◽  
Redox Status ◽  
Heme Oxygenase 1 ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Systemic Oxidative Stress ◽  
Metal On Metal ◽  
Significant Difference

It is widely known that cobalt and chromium ions can enhance the production of reactive oxygen species, known to be damaging to cells by disturbing their redox status and then generating oxidative stress. The aim of the present study was to determine if increased metal ion levels induce a state of oxidative stress in patients with metal-on-metal (MM) hip arthroplasty. Results indicated that there was no significant difference in the concentration of oxidative stress markers (total antioxidants, peroxides, and nitrated proteins) in the patients with MM bearings compared to patients without prostheses. The activity antioxidant enzymes was stable (catalase and glutathione peroxidase) or slightly decreased (superoxide dismutase and heme oxygenase-1) over time. This work is the first to determine the biological effects of metal ions released from MM hip implants with regards to mid-term systemic oxidative stress and showed that the increased levels of Co and Cr ions are not associated with significant oxidative stress damage in the plasma of patients with these implants.

scholarly journals Metabolic, inflammatory and oxidative stress markers in the nitric oxide variation of hemodialysis subjects

2018 ◽  
Author(s):  
Andreza De Paula Santos Epifânio ◽  
Karla Pereira Balbino ◽  
Monica De Paula Jorge ◽  
Sonia M.R Ribeiro ◽  
Ana Vládia Bandeira Moreira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress
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