scholarly journals Clinicopathological analysis of early endometrial cancers

2016 ◽  
Author(s):  
Seema Singhal ◽  
Sunesh Kumar Jain ◽  
D. N. Sharma ◽  
Sandeep Mathur ◽  
Juhi Bharti ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Endometrial Adenocarcinoma ◽  
Tertiary Care ◽  
Myometrial Invasion ◽  
Poor Correlation ◽  
Histopathological Analysis ◽  
Peritoneal Cytology ◽  
Type I ◽  
Positive Peritoneal Cytology

Aim: The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor assessment in early stage endometrial cancer. Materials and Methods: We conducted a prospective descriptive study of 30 cases of endometrial cancer stage 1 examined and treated at a tertiary care teaching institute between the years 2014-15. Results: The patients’ mean age at the time of diagnosis was 56.4 years. The mean parity was two. Postmenopausal bleeding with or without abnormal vaginal discharge was the most frequent symptom; it was present in 84.7% of patients. Co morbidities like hypertension and diabetes were seen in 65% of women. 6/30 patients had family history of some malignancy. All the patients underwent Type I extrafascial hysterectomy with bilateral salpingo oophorectomy, one case had Type I extrafascial hysterectomy with infracolic omentectomy. A total of 10.6% cases had lymph nodes metastasis and none of these patients had ovarian metastasis or positive peritoneal cytology. None of the patients with superficial myometrial invasion (MI) had lymph node metastasis. None of the cases showed positive peritoneal cytology. Staging upgraded from 1a to 1b in 50% of subjects after final histopathological analysis. One patient who was operated as endometrial hyperplasia with atypia actually had endometrial adenocarcinoma in the postoperative specimen. Conclusions: There is a poor correlation between the preoperative and the postoperative tumor assessment.

scholarly journals Clinicopathological analysis of early endometrial cancers

2016 ◽  
Author(s):  
Seema Singhal ◽  
Sunesh Kumar Jain ◽  
D. N. Sharma ◽  
Sandeep Mathur ◽  
Juhi Bharti ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Endometrial Adenocarcinoma ◽  
Tertiary Care ◽  
Myometrial Invasion ◽  
Poor Correlation ◽  
Histopathological Analysis ◽  
Peritoneal Cytology ◽  
Type I ◽  
Positive Peritoneal Cytology

Aim: The study objectives were evaluation of clinicopathological characteristics, correlations between the preoperative and postoperative tumor assessment in early stage endometrial cancer. Materials and Methods: We conducted a prospective descriptive study of 30 cases of endometrial cancer stage 1 examined and treated at a tertiary care teaching institute between the years 2014-15. Results: The patients’ mean age at the time of diagnosis was 56.4 years. The mean parity was two. Postmenopausal bleeding with or without abnormal vaginal discharge was the most frequent symptom; it was present in 84.7% of patients. Co morbidities like hypertension and diabetes were seen in 65% of women. 6/30 patients had family history of some malignancy. All the patients underwent Type I extrafascial hysterectomy with bilateral salpingo oophorectomy, one case had Type I extrafascial hysterectomy with infracolic omentectomy. A total of 10.6% cases had lymph nodes metastasis and none of these patients had ovarian metastasis or positive peritoneal cytology. None of the patients with superficial myometrial invasion (MI) had lymph node metastasis. None of the cases showed positive peritoneal cytology. Staging upgraded fom 1a to 1b in 50% of subjects after final histopathological analysis. One patient who was operated as endometrial hyperplasia with atypia actually had endometrial adenocarcinoma in the postoperative specimen. Conclusions: There is a poor correlation between the preoperative and the postoperative tumor assessment.

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Impact of positive peritoneal cytology on the survival of early stage endometrial cancer

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 5032-5032
Author(s):  
P. M. Tebeu ◽  
Y. Popowski ◽  
H. M. Verkooijen ◽  
C. Bouchardy ◽  
F. Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

A study of positive peritoneal cytology in patients with early-stage endometrial cancer

2020 ◽  
Vol 59 (3) ◽  
pp. 125-128
Author(s):  
Yoko NISHIMURA ◽  
Motoki MATSUURA ◽  
Masato TAMATE ◽  
Noriko TERADA ◽  
Seiro SATOHISA ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

L1-CAM as a predictor of survival in endometrial cancer: An analysis of The Cancer Genome Atlas (TCGA).

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. 5599-5599
Author(s):  
Thanh Hue Dellinger ◽  
Charles Warden ◽  
Ernest Soyoung Han ◽  
Mark Tsuneo Wakabayashi
Keyword(s):  
Endometrial Cancer ◽  
Biomarker Discovery ◽  
Cox Regression ◽  
Myometrial Invasion ◽  
Good Survival ◽  
Peritoneal Cytology ◽  
Type I ◽  
High Grade ◽  
P Values ◽  
Cox Regression Analysis

5599 Background: Despite a good survival rate for early-stage endometrial cancers (ECs), the prognosis for advanced-stage ECs remains poor, with no biomarkers and few therapeutic options currently in existence. L1-cell adhesion molecule (L1-CAM), a glycoprotein which functions in adhesion and migration of tumor cells, has been associated with a poor prognosis in Type I endometrial cancer (ASCO 2011 Abstract #5091). We evaluated the role of L1-CAM among both Type I and II ECs in TCGA. Methods: Partek Genomics Suit was used to define differentially expressed genes with p-values for clinical associations (ANOVA with linear contrast for discrete variables and linear regression for continuous variables). Differences in survival between “high” and “low” expression groups (defined by median expression) were compared using Cox regression analysis, with p-values calculated via log-rank test, using the ‘survival’ package in R. Results: Of 451 downloadable tumor samples, 335 tumors with both clinical and gene expression data were analyzed. Median age was 63 yrs. (range 31-90 yrs.). Stage I, II, III, and IV comprised 65%, 7%, 23%, and 5%, respectively. 82% were endometrioid; 16% (n = 52) serous. Grade 1, 2, and 3 comprised 24%, 27%, and 49%, respectively. Median follow-up was 19.5 months. High L1-CAM expression was found in older (p = 0.0005), suboptimally debulked (p=0.002), and African-American patients (p = 0.0003), and those with high grade (p = 0.008), serous histology (p <0.00001), higher stage (p = 0.0004), positive peritoneal cytology (p = 0.007), deep myometrial invasion (p = 0.02), and positive pelvic (p = 0.003) and para-aortic lymph nodes (p = 0.002). High L1-CAM expression was associated with poor survival with a median overall survival of 17.2 months compared to 21.3 months for low L1-expressing endometrial tumors (HR= 3.1, CI=1.3 -7.3, p = 0.007). Conclusions: L1-CAM expression is associated with poorer survival and high-risk clinicopathologic factors in endometrial cancer. Its prevalence in Type II ECs, such as high-grade, serous ECs, makes it a particularly attractive target for both novel biomarker discovery and therapeutic targeting.

scholarly journals Positive peritoneal cytology in early-stage endometrial cancer does not influence prognosis

2004 ◽  
Vol 91 (4) ◽  
pp. 720-724 ◽  
Author(s):  
P-M Tebeu ◽  
Y Popowski ◽  
H M Verkooijen ◽  
C Bouchardy ◽  
F Ludicke ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

scholarly journals Positive peritoneal cytology is an independent risk-factor in early stage endometrial cancer

2013 ◽  
Vol 128 (1) ◽  
pp. 77-82 ◽  
Author(s):  
Gunjal Garg ◽  
Feng Gao ◽  
Jason D. Wright ◽  
Andrea R. Hagemann ◽  
David G. Mutch ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Early Stage ◽  
Peritoneal Cytology ◽  
Positive Peritoneal Cytology ◽  
Early Stage Endometrial Cancer

Prolonged Conservative Treatment of Endometrial Cancer Patients: More Than 1 Pregnancy Can Be Achieved

2011 ◽  
Vol 21 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Tamar Perri ◽  
Jacob Korach ◽  
Walter H. Gotlieb ◽  
Mario Beiner ◽  
Dror Meirow ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Conservative Treatment ◽  
Early Stage ◽  
Intrauterine Device ◽  
Endometrial Adenocarcinoma ◽  
Tertiary Care ◽  
Young Patients ◽  
High Recurrence Rate ◽  
High Dose ◽  
Endometrioid Adenocarcinoma

Background:Preserving reproductive function in young patients with early endometrial cancer is an accepted concept today. The safety and feasibility of long-term conservative treatment, allowing more than 1 pregnancy, remain to be ascertained.Methods:This study was a retrospective chart review of a 27 women with endometrioid adenocarcinoma of the endometrium, who were treated conservatively at 2 tertiary-care institutions. Treatment comprised oral high-dose progestins with or without a levonorgestrel-releasing intrauterine device. Endometrial biopsy was repeated every 2 to 3 months.Results:Over 7.8 to 412 months (median, 57.4 months), tumors regressed completely in 24 (89%) of 27 patients and partially in 2 patients, with 79% responding within 1 to 17 months. Of the complete responders, 15 (62%) of 24 had a recurrence; 4 underwent hysterectomy, and 11 underwent subsequent progestational treatment. All 11 responded, and 3 subsequently conceived. After 2 to 4 years, 5 patients again had a recurrence, of whom 3 underwent hysterectomy. Overall, 2 patients developed ovarian adenocarcinoma. All patients are currently disease-free. Conception occurred in 14 (51.8%) of 27 patients, in 5 more than once. There were 17 live births, and 2 patients are pregnant.Conclusions:According to our data, prolonged progestational therapy for early-stage endometrial adenocarcinoma, allowing women to conceive, is feasible and apparently does not alter clinical outcome. Patients should be advised of the high recurrence rate and possible concomitant ovarian malignancy.

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