scholarly journals Do the New Hydrophilic Surface Have Any Influence on Early Success Rate and Implant Stability during Osseointegration Period? Four-Month Preliminary Results from a Split-Mouth, Randomized Controlled Trial

2019 ◽  
Vol 13 (01) ◽  
pp. 095-101 ◽  
Author(s):  
Marco Tallarico ◽  
Nicola Baldini ◽  
Matteo Martinolli ◽  
Erta Xhanari ◽  
Yong-Jin Kim ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Insertion Torque ◽  
Hydrophilic Surface ◽  
Implant Stability ◽  
Exact Test ◽  
Randomized Controlled ◽  
Implant Stability Quotient ◽  
Implant Placement ◽  
Time Point

Abstract Objective The objective of this study is to compare the implant stability of Hiossen ET III implants with its new hydrophilic (NH) surface and Hiossen ET III implants with the sandblasted and acid-etched (SA) surface. Materials and Methods Patients required at least two teeth to be rehabilitated with a fixed, implant-supported restoration, consecutively enrolled. Patients randomly received SA surface implants (SA group) or SA implants with a newly developed bioabsorbable apatite nanocoating (NH group). Outcome measures were implant and prosthetic survival rate, complications, insertion torque, and implant stability quotient (ISQ) measured at implant placement and every week up to 8 weeks after implant placement. Comparison between groups was made by unpaired t-test, while the comparison between each follow-up will be made by paired t-tests to detect any change during the follow-up. Complications and failures were compared using Fisher's exact test. Results A total of 14 patients were treated with 28 implants (14 SA and 14 NH). No implant and prosthesis failed 4 months after implant placement. No complications were experienced. At the 2nd week after implants placement, two implants in the SA group showed discontinuous measurements versus none in the NH group (p = 0.4815). Implants unscrewed during ISQ measurements and were rescrewed. Data recording stopped for 6 weeks. Both implants osseointegrated without any further complication. The NH implants did not show physiological ISQ decrease between 2nd and 4th week after implant placement, showing a more even pattern of ISQ values compared with SA implants (77.1 ± 4.6 vs. 72.9 ± 11.5; difference: 4.2 ± 12.1; p = 0.258). High ISQ values were found in both groups at each time point. Conclusions NH implants are a viable alternative to SA surface, as they seem to avoid the ISQ drop during the remodeling phase.

scholarly journals Role of New Hydrophilic Surfaces on Early Success Rate and Implant Stability: 1-Year Post-loading Results of a Multicenter, Split-Mouth, Randomized Controlled Trial

2020 ◽  
Author(s):  
Marco Tallarico ◽  
Nicola Baldini ◽  
Fulvio Gatti ◽  
Matteo Martinolli ◽  
Erta Xhanari ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Controlled Trial ◽  
Survival Rates ◽  
Insertion Torque ◽  
Implant Stability ◽  
Randomized Controlled ◽  
Group Outcomes ◽  
Significant Difference ◽  
Multicenter Randomized Controlled Trial

Abstract Objective To compare early implant failure and implant stability of one-stage Hiossen ET III implants with its new hydrophilic (NH) surface, compared with Hiossen ET III implants with the sandblasted and acid-etched (SA) surface at 1-year follow-up. Materials and Methods This study was designed as a split-mouth, multicenter randomized controlled trial aimed to compare SA surface implants (SA group) and NH surface, (NH group). Outcomes were implant and prosthetic survival rates, complications, the insertion torque at implant placement, and implant stability quotient (ISQ) values. Results Twenty-nine patients (mean age 59.9 ± 11.3 years) were treated and followed up to 1 year after loading. No patient dropped out. Fifty-eight implants (29 SA group and 29 NH group) were placed. No implants or prostheses failed and no complications were experienced during follow-up. The mean insertion torque was 40.5 ± 3.23 (38.17–41.83) Ncm in the SA group and 40.48 ± 3.49 (38.02–41.98) Ncm in the NH group (p = 0.981). There was a statistically significant difference at the second week (T2) with higher values in the NH group (p = 0.041). Similar results were found in the maxilla (p = 0.045), but not in the mandible (p = 0.362). A positive correlation was found between initial insertion torque and ISQ with higher value in the NH group (0.73 vs. 0.66). Conclusions NH implants are a viable alternative to SA surface, as they seem to avoid the ISQ drop during the bone remodeling phase.

scholarly journals Comparing the Efficacy of an Identical, Tailored Smoking Cessation Intervention Delivered by Mobile Text Messaging Versus Email: Randomized Controlled Trial (Preprint)

2018 ◽  
Author(s):  
Inger Torhild Gram ◽  
Dillys Larbi ◽  
Silje Camilla Wangberg
Keyword(s):  
Smoking Cessation ◽  
Text Messaging ◽  
Controlled Trial ◽  
Text Message ◽  
Population Level ◽  
Randomized Controlled ◽  
Cessation Intervention ◽  
Double Blinded ◽  
Time Point

BACKGROUND There is a need to deliver smoking cessation support at a population level, both in developed and developing countries. Studies on internet-based and mobile phone–based smoking cessation interventions have shown that these methods can be as effective as other methods of support, and they can have a wider reach at a lower cost. OBJECTIVE This randomized controlled trial (RCT) aimed to compare, on a population level, the efficacy of an identical, tailored smoking cessation intervention delivered by mobile text messaging versus email. METHODS We conducted a nationwide 2-arm, double-blinded, fully automated RCT, close to a real-world setting, in Norway. We did not offer incentives to increase participation and adherence or to decrease loss to follow-up. We recruited users of the website, slutta.no, an open, free, multi-component Norwegian internet-based smoking cessation program, from May 2010 until October 2012. Enrolled smokers were considered as having completed a time point regardless of their response status if it was 1, 3, 6, or 12 months post cessation. We assessed 7315 participants using the following inclusion criteria: knowledge of the Norwegian language, age 16 years or older, ownership of a Norwegian cell phone, having an email account, current cigarette smoker, willingness to set a cessation date within 14 days (mandatory), and completion of a baseline questionnaire for tailoring algorithms. Altogether, 6137 participants were eligible for the study and 4378 participants (71.33%) provided informed consent to participate in the smoking cessation trial. We calculated the response rates for participants at the completed 1, 3, 6, and 12 months post cessation. For each arm, we conducted an intention-to-treat (ITT) analysis for each completed time point. The main outcome was 7-day self-reported point prevalence abstinence (PPA) at the completed 6 months post cessation. We calculated effect size of the 7-day self-reported PPA in the text message arm compared with the email arm as odds ratios (ORs) with 95% CIs for the 4 time points post cessation. RESULTS At 6 months follow-up, 21.06% (384/1823) of participants in the text message arm and 18.62% (333/1788) in the email arm responded (<italic>P</italic>=.07) to the surveys. In the ITT analysis, 11.46% (209/1823) of participants in the text message arm compared with 10.96% (196/1788) in the email arm (OR 1.05, 95% CI 0.86-1.30) reported to have achieved 7 days PPA. CONCLUSIONS This nationwide, double-blinded, large, fully automated RCT found that 1 in 9 enrolled smokers reported 7-day PPA in both arms, 6 months post cessation. Our study found that identical smoking cessation interventions delivered by mobile text messaging and email may be equally successful at a population level. CLINICALTRIAL ClinicalTrials.gov NCT01103427; https://clinicaltrials.gov/ct2/show/NCT01103427

scholarly journals Comparing the Efficacy of an Identical, Tailored Smoking Cessation Intervention Delivered by Mobile Text Messaging Versus Email: Randomized Controlled Trial

10.2196/12137 ◽  
2019 ◽  
Vol 7 (9) ◽  
pp. e12137 ◽  
Author(s):  
Inger Torhild Gram ◽  
Dillys Larbi ◽  
Silje Camilla Wangberg
Keyword(s):  
Smoking Cessation ◽  
Text Messaging ◽  
Controlled Trial ◽  
Text Message ◽  
Population Level ◽  
Randomized Controlled ◽  
Cessation Intervention ◽  
Double Blinded ◽  
Time Point

Background There is a need to deliver smoking cessation support at a population level, both in developed and developing countries. Studies on internet-based and mobile phone–based smoking cessation interventions have shown that these methods can be as effective as other methods of support, and they can have a wider reach at a lower cost. Objective This randomized controlled trial (RCT) aimed to compare, on a population level, the efficacy of an identical, tailored smoking cessation intervention delivered by mobile text messaging versus email. Methods We conducted a nationwide 2-arm, double-blinded, fully automated RCT, close to a real-world setting, in Norway. We did not offer incentives to increase participation and adherence or to decrease loss to follow-up. We recruited users of the website, slutta.no, an open, free, multi-component Norwegian internet-based smoking cessation program, from May 2010 until October 2012. Enrolled smokers were considered as having completed a time point regardless of their response status if it was 1, 3, 6, or 12 months post cessation. We assessed 7315 participants using the following inclusion criteria: knowledge of the Norwegian language, age 16 years or older, ownership of a Norwegian cell phone, having an email account, current cigarette smoker, willingness to set a cessation date within 14 days (mandatory), and completion of a baseline questionnaire for tailoring algorithms. Altogether, 6137 participants were eligible for the study and 4378 participants (71.33%) provided informed consent to participate in the smoking cessation trial. We calculated the response rates for participants at the completed 1, 3, 6, and 12 months post cessation. For each arm, we conducted an intention-to-treat (ITT) analysis for each completed time point. The main outcome was 7-day self-reported point prevalence abstinence (PPA) at the completed 6 months post cessation. We calculated effect size of the 7-day self-reported PPA in the text message arm compared with the email arm as odds ratios (ORs) with 95% CIs for the 4 time points post cessation. Results At 6 months follow-up, 21.06% (384/1823) of participants in the text message arm and 18.62% (333/1788) in the email arm responded (P=.07) to the surveys. In the ITT analysis, 11.46% (209/1823) of participants in the text message arm compared with 10.96% (196/1788) in the email arm (OR 1.05, 95% CI 0.86-1.30) reported to have achieved 7 days PPA. Conclusions This nationwide, double-blinded, large, fully automated RCT found that 1 in 9 enrolled smokers reported 7-day PPA in both arms, 6 months post cessation. Our study found that identical smoking cessation interventions delivered by mobile text messaging and email may be equally successful at a population level. Trial Registration ClinicalTrials.gov NCT01103427; https://clinicaltrials.gov/ct2/show/NCT01103427

scholarly journals A Simplified Prosthetic Implant Loading Protocol: 1-Year Clinical Follow-Up Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Lorenzo Andreatta ◽  
Malin Bjursten Brailsford ◽  
Jakob Zwaan
Keyword(s):  
Bone Remodeling ◽  
Treatment Time ◽  
Treatment Protocol ◽  
Immediate Loading ◽  
Insertion Torque ◽  
Implant Stability ◽  
Implant Placement ◽  
Significant Difference ◽  
One Year

Purpose. To retrospectively investigate the one-year clinical outcome following a standardized treatment protocol for immediate loading. The protocol mandates predefined requirements for implant stability. If fulfilled, immediate loading of the implants is performed with a simplified prosthetic protocol which includes one-time impression at the time of surgery and definitive restoration within eight weeks. Methods. Twenty-five patients were treated with 48 Neoss ProActive Tapered implants. Minimum primary stability was established before subjecting the implants to immediate nonfunctional load. Definitive prostheses were delivered six to eight weeks from implant placement. Insertion torque (IT), resonance frequency analysis (RFA), intraoral radiographs, and impressions of implant positions were registered at implant placement. During clinical follow-up, RFA was measured at two, four, and six to eight weeks and six months from implant placement to monitor continued implant stability. Marginal bone level measurements were performed at implant placement, six-month, and one-year follow-up visits. Results. IT was over 40 N·cm for 46 implants. Two implants with IT <30 N·cm were both splinted to another implant with IT >50 N·cm, tightening the retention screw with low forces. No implants were lost during the observation period. Mean RFA measurements remained stable without any decrease during the initial six-month healing phase. Mean marginal bone remodeling was −0.47 ± 0.38 mm from implant placement to 1 year. No significant difference was found for marginal bone remodeling between implants placed in the healed bone or fresh extraction sockets. Conclusion. Within the limits of this study, it is concluded that using a simplified immediate loading protocol can be predictably applied to reduce the overall treatment time and the number of clinical sessions.

Randomized controlled trial on the treatment of otitis externa with one per cent silver nitrate gel

2004 ◽  
Vol 118 (2) ◽  
pp. 93-96 ◽  
Author(s):  
Piet van Hasselt ◽  
Hugo Gudde
Keyword(s):  
Silver Nitrate ◽  
Otitis Externa ◽  
Adverse Reactions ◽  
Controlled Trial ◽  
Treatment Method ◽  
Fisher Exact Test ◽  
Exact Test ◽  
Randomized Controlled ◽  
Parallel Group

Otitis externa (OE) and especially otomycosis can be very persistent and difficult to control. In the present study the efficacy of treatment of OE with a single instillation in the ear canal of one per cent silver nitrate in three per cent hypromellose gel compared to 0.1 per cent silver nitrate gel was tested in a single-blinded randomized controlled parallel group study. The outcome measure was complete resolution of the OE after one week. Forty-four patients with refractory, bacterial as well as fungal, OE entered the study, comprising 30 ears in each treatment arm. Eight patients defaulted from follow-up,five ears in each treatment arm. A single instillation of one per cent silver nitrate gel cured 23 (92 per cent) of 25 ears with OE, whereas with 0.1 per cent silver nitrate gel seven (28 per cent) of 25 ears treated were cured (Fisher-exact test, p-exact = 0.00010). In a non-controlled series of 120 ears 93.3 per cent needed only a single instillation of one per cent silver nitrate gel while another five per cent were cured after a second instillation a week later. There were no adverse reactions. OE can be treated effectively with instillation of one per cent silver nitrate gel and is particularly useful in recalcitrant otomycosis. The treatment method saves both cost and time.

scholarly journals The Effect of Autologous Platelet Concentrates on Maxillary Sinus Augmentation: A Meta-Analysis of Randomized Controlled Trials and Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Yusheng Meng ◽  
Xingxing Huang ◽  
Min Wu ◽  
Xiuqiao Yang ◽  
Yun Liu
Keyword(s):  
Bone Substitute ◽  
Meta Analysis ◽  
Controlled Trials ◽  
Platelet Concentrates ◽  
Implant Stability ◽  
Sinus Augmentation ◽  
Randomized Controlled ◽  
Implant Stability Quotient ◽  
Implant Placement ◽  
Autologous Platelet

Introduction. To assess the efficacy of the autologous platelet concentrates (APCs) combined with autologous bone or bone substitute for the maxillary sinus floor lifting by a meta-analysis. Materials and Methods. Electronic databases (PUBMED, Web of Science, EMBASE through OVID, and Cochrane Library) were searched until Dec 31, 2019, and only randomized controlled trials (RCTs) in English were identified. Outcome variables included histologic evaluation, the implant stability quotient values, and radiographic evaluation. Data were analyzed by Revman5.3; the estimate of effect sizes was expressed as the 95% confidence interval; and the risk of bias was evaluated using the Cochrane Collaboration tool. Results. 11 RCTs involving 141 patients (214 sites) were included in our meta-analysis, which indicated that the differences in the percentage of contact length among newly formed bone (2.61%, 95% CI, -1.18% to 7.09%), soft tissue area (-0.15%, 95% CI, -0.54% to 0.24%), and residual bone substitute material (-5.10%, 95% CI, -10.56% to 0.36%) in the APC group lacked statistical significance. Besides, there was the same effect on the implant stability quotient (ISQ) values of APC group who underwent implant placement 4 months after sinus augmentation and control group who received implant placement 8 months after sinus augmentation (-0.48, 95% CI, -1.68 to 0.72). No significant effect of APCs on the bone density was found (1.05%, 95% CI, -1.69% to 3.82%). Conclusions. The use of APCs in sinus augmentation may be further shorten the time required for bone graft maturation and allow earlier implant placement, but cannot enhance the bone formation in the long term. It is not currently recommended for routine use APCs as an osteoinductive material to bone grafting in sinus augmentation.

scholarly journals Relation Between Insertion Torque and Implant Stability Quotient: A Clinical Study

2021 ◽  
Author(s):  
João Paulo do Vale Souza ◽  
Clóvis Lamartine de Moraes Melo Neto ◽  
Lucas Tavares Piacenza ◽  
Emily Vivianne Freitas da Silva ◽  
André Luiz de Melo Moreno ◽  
...  
Keyword(s):  
Tooth Extraction ◽  
Primary Stability ◽  
Insertion Torque ◽  
Resonance Frequency Analysis ◽  
Implant Stability ◽  
Significance Level ◽  
Positive Correlation ◽  
Implant Stability Quotient ◽  
Implant Placement ◽  
Secondary Stability

Abstract Objectives This study aimed to assess the relation between the insertion torque and implant stability quotient (ISQ recorded immediately and 6 months after implant placement). Materials and Methods Twenty-five patients over the age of 18 years were selected for this study. One implant was placed per patient after tooth extraction. The implant site needed 15 mm in height and 8 mm in width. All implants had the same size (11.5 × 3.75 mm) and brand (Hexagonal Morse cone, DSP Biomedical). The insertion torque (Ncm) and resonance frequency analysis (ISQ value) (Osstell Mentor) were used to assess the primary stability (on the day of surgery). After 6 months, ISQ value was used to assess the secondary stability of each implant. Statistical Analysis The insertion torque data were correlated with ISQ measurements by using Pearson’s correlation. The significance level was 5%. Results There was a positive correlation between insertion torque and initial ISQ (correlation: 0.457; p = 0.022); however, no correlation was found between insertion torque and final ISQ (p = 0.308). Conclusion The present study demonstrated that there is a positive correlation between the insertion torque and the initial ISQ. Therefore, the higher the insertion torque, the higher the initial ISQ (or vice versa).

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