Effect of Degree of Arterial Inflow on a Functioning Free Muscle Transplantation in a Rat Gracilis Model

2020 ◽  
Vol 36 (06) ◽  
pp. 458-465
Author(s):  
Ahmet Hamdi Sakarya ◽  
Nicholas Thu Khoa Do ◽  
Yen-Lin Huang ◽  
Johnny Chuieng-Yi Lu ◽  
Tommy Nai-Jen Chang ◽  
...  
Keyword(s):  
Blood Flow ◽  
Functional Outcome ◽  
Low Flow ◽  
Control Group ◽  
Muscle Transplantation ◽  
Functional Failure ◽  
Failure Group ◽  
Significant Difference ◽  
Arterial Inflow ◽  
Free Muscle Transplantation

Abstract Background Various surgical effects have previously been studied in an attempt to improve the functional outcome of the functioning free muscle transplantation (FFMT). However, the effect of the recipient arterial inflow on the FFMT has remained uninvestigated. This study was to investigate whether or not high flow versus low flow will affect the functional outcome of FFMT. Methods Rat's left gracilis FFMT model was devised and the nutrient arterial inflow was modified. Twenty-four Lewis rats were divided evenly into relatively high (0.071 mL/min) and relatively low (0.031 mL/min) blood flow groups (p < 0.001). The unoperated right sides served as the controls. Cases resulting in poor function were additionally grouped as functional failure group for comparison. Regular swimming exercise was implemented at 1 month postoperatively for 3 months. Gracilis muscle functions were then evaluated. Results Compared groups were: control (n = 13), low blood flow (n = 10), high blood flow (n = 8), and functional failure (n = 5). The control group showed superior functional results over the experimental groups (p < 0.0001). In the experimental group, successful group showed superior over the poor function group (p < 0.01). However, there was no significant difference between the high- and low-flow groups. Conclusion This is the first study to evaluate the effect of arterial inflow on the FFMT. The rate of blood flow (relatively high vs. low) has little effect on the functional outcome of transferred muscle. Survival of FFMT is the major concern while performing FFMT surgery. Arterial inflow while choosing the recipient artery is not the factor for consideration.

scholarly journals Pancreatic capillary blood flow during caerulein-induced pancreatitis evaluated by a laser-doppler flowmeter in rats

2003 ◽  
Vol 18 (suppl 5) ◽  
pp. 18-22 ◽  
Author(s):  
Roberto Ferreira Meirelles Jr. ◽  
Reginaldo Ceneviva ◽  
José Liberato Ferreira Caboclo ◽  
Michael M. Eisenberg
Keyword(s):  
Blood Flow ◽  
Serum Amylase ◽  
Tissue Injury ◽  
Capillary Blood ◽  
Laser Doppler ◽  
Capillary Blood Flow ◽  
Control Group ◽  
Laser Doppler Flowmeter ◽  
Significant Difference ◽  
Doppler Flowmeter

PURPOSE: The pancreatic capillary blood flow (PCBF) was studied to determine its alterations during caerulein-induced pancreatitis in rats. METHODS: Twenty rats were divided in groups: control and caerulein. A laser-Doppler flowmeter to measure PCBF continuously was used. Blood pressure (BP) and heart rate (HR) were monitored. Serum biochemistry analyses were determined. Histopathological study was performed. RESULTS: The PCBF measured a mean of 109.08 ± 14.54% and 68.24 ± 10.47% in control group and caerulein group, respectively. Caerulein group had a mean decrease of 31.75 ± 16.79%. The serum amylase was 1323.70 ± 239.10U.I-1 and 2184.60 ± 700.46U.I-1 in control and caerulein groups, respectively. There was a significant difference in the PCBF (p<0.05) and serum amylase (p<0.05) when compared to control and caerulein groups. Although micro and microvacuolization were seen in 30% in caerulein group, no significant difference was seen between the groups. CONCLUSION: A decrease in the PCBF may be one of the leading events and it is present before histopathological tissue injury had been established in this model of acute pancreatitis.

Erratum: Effect of Degree of Arterial Inflow on a Functioning Free Muscle Transplantation in a Rat Gracilis Model

2020 ◽  
Vol 36 (06) ◽  
pp. e1-e1
Author(s):  
Ahmet Hamdi Sakarya ◽  
Nicholas Thu Khoa Do ◽  
Yen-Lin Huang ◽  
Johnny Chuieng-Yi Lu ◽  
Tommy Nai-Jen Chang ◽  
...  
Keyword(s):  
Muscle Transplantation ◽  
Arterial Inflow ◽  
Free Muscle Transplantation

scholarly journals Effect of inguinal hernia on the thickness and blood flow of spermatic cord in boys

2019 ◽  
Vol 2 (2) ◽  
pp. e000030
Author(s):  
Shoujiang Huang ◽  
Canping Li ◽  
Xiuzhen Yang ◽  
Jianfeng Liang ◽  
Dongpi Wang
Keyword(s):  
Blood Flow ◽  
Inguinal Hernia ◽  
Spermatic Cord ◽  
Peak Systolic Velocity ◽  
Control Group ◽  
Pampiniform Plexus ◽  
Significant Difference ◽  
Highly Correlated ◽  
And Control ◽  
The Relationship

ObjectiveTo evaluate the effect of inguinal hernia (IH) on the spermatic cord using spermatic cord ultrasonography (SCU).MethodsFrom January 2016 to January 2017, boys with IH who received SCU at the start of open herniorrhaphy (OH) were enrolled in this study. The age and weight at SCU, width of the spermatic cord (SC-W), peak systolic velocity (PSV) in the spermatic artery (SA-PSV) and velocity in the pampiniform plexus (PP-V), and the interval between the initial and the second OH in boys with metachronous inguinal hernia (MIH) were recorded, and the relationship among them was studied. Boys with unilateral IH comprised the IH group, and boys with MIH comprised the MIH group. Boys with polydactylism served as the control. One-way analysis of variance tested the differences among groups. Spearman’s r tested the relationship between SC-W in the MIH group and the interval.ResultsA total of 80 boys were enrolled in this study (IH group 29, MIH group 26, and control group 25). SA-PSV and PP-V in the hernia side were faster and slower than the control, respectively. There was no significant difference in PP-V and SA-PSV of the treated side in the MIH group and in the control group. After herniorrhaphy, SC-W was tapered down to normal size. SC-W, SA-PSV, and PP-V in the treated side were all highly correlated to the interval in a curvilinear manner.ConclusionPSV was positively correlated with SC-W in boys with IH, and PP-V was negatively correlated; herniorrhaphy could reverse the impairment.

scholarly journals Endovascular thrombectomy for the treatment of ischemic stroke: An updated meta-analysis for a randomized controlled trial

2021 ◽  
Vol 9 (3) ◽  
pp. 166-176
Author(s):  
Jia Feng ◽  
Zhihan Zhu ◽  
Ahmed Waqas ◽  
Lukui Chen
Keyword(s):  
Ischemic Stroke ◽  
Subarachnoid Hemorrhage ◽  
Functional Outcome ◽  
Meta Analysis ◽  
Intervention Group ◽  
Intravenous Thrombolysis ◽  
Control Group ◽  
Endovascular Thrombectomy ◽  
Symptomatic Intracerebral Hemorrhage ◽  
Significant Difference

Objective:To evaluate whether endovascular thrombectomy combined with intravenous thrombolysis is superior to the standard treatment of intravenous thrombolysis for the treatment of ischemic stroke.Methods:A meta-analysis of 12 studies obtained by searching PubMed and Web of Science database was performed to determine whether the difference in mortality (within 7 days or 90 days), functional outcome (modified Rankin Scale, 0-2), hemorrhage (symptomatic intracerebral hemorrhage, and subarachnoid hemorrhage), and recurrent ischemic stroke rate at 90 days between patients who underwent mechanical intravenous thrombolysis with (intervention) and without (control) endovascular thrombectomy.Results:As compared with the control group, patients in the intervention group had lower 90-day mortality [summary risk ratio (RR) = 0.83, 95% confidence interval (CI): 0.69-0.99; n = 1309/1070], higher recanalization rate (RR = 2.24, 95% CI: 1.97-2.56; n = 504/497), better functional outcome (modified Rankin score: 0-2; RR = 1.41, 95% CI: 1.29-1.54; n = 1702/1502), and higher rate of subarachnoid hemorrhage (RR = 2.40, 95% CI: 1.45-3.99; n = 1046/875) without significant difference in the 7-day mortality (RR = 1.12, 95% CI: 0.84-1.50; n = 951/773), symptomatic intracranial hemorrhage (RR = 1.12, 95% CI: 0.82-1.54; n = 1707/1507), or recurrent ischemic stroke (RR = 0.90, 95% CI: 0.52-1.54; n = 718/506).Conclusion:Our results demonstrated that patients in the intervention group had lower mortality and better functional outcomes than the control group. Although patients in the intervention group had a higher rate of subarachnoid hemorrhage; hence, endovascular thrombectomy combined with intravenous thrombolysis is still a beneficial intervention for a defined population of stroke patients.

scholarly journals Effects of Arterial Needle Placement in Arteriovenous Fistula on Dialysis Adequacy of End-Stage Renal Disease Patients Undergoing Maintenance Hemodialysis

2016 ◽  
Vol 1 (2) ◽  
Keyword(s):  
Blood Flow ◽  
Arteriovenous Fistula ◽  
Intervention Group ◽  
Maintenance Hemodialysis ◽  
Control Group ◽  
Needle Placement ◽  
Dialysis Adequacy ◽  
Significant Difference ◽  
Stage Renal Disease ◽  
End Stage

Objective: The arterial needle placement in arteriovenous fistula (AVF) can either be antegrade (in the direction of blood flow or pointing towards the heart) or retrograde (against the direction of blood flow) while venous needle placement should always be in the same direction as the blood flow. This study determined the effects of arterial needle placement in the arteriovenous fistula on dialysis adequacy of End-Stage Renal Disease (ESRD) patients undergoing maintenance hemodialysis in United Candelaria Doctors Hospital - Nephro Synergies Inc. (UCDHNSI) Hemodialysis Center. Methods: A randomized controlled trial design was used in the study. A total of 20 non-diabetic, non-cardiac patients on maintenance hemodialysis for more than 6 months were randomized either to the intervention group (patients’ AVF were cannulated in a retrograde manner) or the control group (patients’ AVF were cannulated in an antegrade manner). Urea reduction ratio (URR) and Kt/V as well as access recirculation percentage were used to determine dialysis adequacy. Pre-dialysis, in the first 30 minutes of dialysis initiation and post-dialysis blood samples were obtained in each patient in 6 succeeding hemodialysis considering dialyzer reuse up to fifth reuse. Means were compared by independent t-test. Results: The findings of the study revealed that the mean URR and Kt/V of the subjects cannulated in retrograde manner and antegrade manner were 69.35% and 1.45, and 74.65% and 1.70, respectively. The mean access recirculation percentage of the subjects was 4.65% in the intervention group and 3.02% in the control group. There was a significant difference on URR and Kt/V of the subjects using retrograde and antegrade arterial needle placement in 6 succeeding hemodialysis sessions. There was no significant difference on access recirculation percentage of the subjects using retrograde and antegrade arterial needle placement in 6 succeeding hemodialysis sessions. Conclusions: Antegrade arterial needle placement provides more adequate hemodialysis than retrograde arterial needle placement in terms of URR and Kt/V values among non-diabetic, non-cardiac patients undergoing maintenance hemodialysis in 6 succeeding hemodialysis sessions. The directions of the arterial needle either retrograde and antegrade did not have significant effects on access recirculation.

Influence of electroacupuncture stimulation on skin temperature, skin blood flow, muscle blood volume and pupil diameter

2019 ◽  
Vol 38 (2) ◽  
pp. 86-92
Author(s):  
Tomoko Kubota ◽  
Hidetoshi Mori ◽  
Tateyuki Morisawa ◽  
Kazuyo Hanyu ◽  
Hiroshi Kuge ◽  
...  
Keyword(s):  
Blood Flow ◽  
Skin Temperature ◽  
Blood Volume ◽  
Skin Blood Flow ◽  
Pupil Diameter ◽  
Spinal Reflexes ◽  
Control Group ◽  
Acupuncture Points ◽  
Tibialis Muscle ◽  
Significant Difference

Objective: To examine the effect of electroacupuncture (EA) stimulation on multiple physiological indices and to evaluate both local and systemic physiological responses induced by the stimulation. Methods: 15 healthy male college students participated in an experimental crossover study. They received two kinds of interventions: one with EA stimulation and one without EA stimulation on different days. Two disposable acupuncture needles were inserted at two traditional acupuncture points (ST36 and ST38), located along the anterior tibialis muscle. EA stimulation was administered for 10 min. Skin temperature (ST), skin blood flow (SBF) and muscle blood volume (MBV) were recorded near the stimulation sites, while the pupil diameter (PD) was measured before, during and after the interventions. Results: ST, SBF and MBV increased significantly following EA stimulation. PD of the right and left eyes decreased significantly following EA stimulation. There was a significant difference in ST responses between the groups (P=0.001). For SBF, MBV and PD, no significant differences were demonstrated between the groups. Conclusions: Our study showed that 10 min of EA stimulation increased ST, SBF and MBV, and decreased PD, compared to baseline, while no significant change was observed in the control group. This suggests that EA stimulation alters local blood flow and ST, and these responses are likely mediated via segmental spinal reflexes, supraspinal reflexes involving parasympathetic activation, and other mechanisms.

scholarly journals Impact of Goal-Directed Therapy on Delayed Ischemia After Aneurysmal Subarachnoid Hemorrhage

Stroke ◽  
2020 ◽  
Vol 51 (8) ◽  
pp. 2287-2296 ◽  
Author(s):  
Aida Anetsberger ◽  
Jens Gempt ◽  
Manfred Blobner ◽  
Florian Ringel ◽  
Ralf Bogdanski ◽  
...  
Keyword(s):  
Subarachnoid Hemorrhage ◽  
Functional Outcome ◽  
Standard Therapy ◽  
Aneurysmal Subarachnoid Hemorrhage ◽  
Controlled Trial ◽  
Clinical Care ◽  
Delayed Cerebral Ischemia ◽  
Control Group ◽  
Unique Identifier ◽  
Significant Difference

Background and Purpose: Delayed cerebral ischemia (DCI) is the most important cause for a poor clinical outcome after a subarachnoid hemorrhage. The aim of this study was to assess whether goal-directed hemodynamic therapy (GDHT), as compared to standard clinical care, reduces the rate of DCI after subarachnoid hemorrhage. Methods: We conducted a prospective randomized controlled trial. Patients >18 years of age with an aneurysmal subarachnoid hemorrhage were enrolled and randomly assigned to standard therapy or GDHT. Advanced hemodynamic monitoring and predefined GDHT algorithms were applied in the GDHT group. The primary end point was the occurrence of DCI. Functional outcome was assessed using the Glasgow Outcome Scale (GOS) 3 months after discharge. Results: In total, 108 patients were randomized to the control (n=54) or GDHT group (n=54). The primary outcome (DCI) occurred in 13% of the GDHT group and in 32% of the control group patients (odds ratio, 0.324 [95% CI, 0.11–0.86]; P =0.021). Even after adjustment for confounding parameters, GDHT was found to be superior to standard therapy (hazard ratio, 2.84 [95% CI, 1.18–6.86]; P =0.02). The GOS was assessed 3 months after discharge in 107 patients; it showed more patients with a low disability (GOS 5, minor or no deficits) than patients with higher deficits (GOS 1–4) in the GDHT group compared with the control group (GOS 5, 66% versus 44%; GOS 1–4, 34% versus 56%; P =0.025). There was no significant difference in mortality between the groups. Conclusions: GDHT reduced the rate of DCI after subarachnoid hemorrhage with a better functional outcome (GOS=5) 3 months after discharge. Registration: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01832389.

THE ROLE OF LASER AND ULTRASONIC DOPPLER FLOWMETRY IN THE CORRECTION OF COSMETIC DEFECTS OF THE ANTERIOR ABDOMINAL WALL AND PREVENTION OF COMPLICATIONS

2021 ◽  
Vol 74 (7) ◽  
pp. 1605-1611
Author(s):  
Orest V. Panchuk ◽  
Yaroslav M. Susak ◽  
Ievgen G. Donets ◽  
Pavlo l. Byck ◽  
Olena F. Panchuk ◽  
...  
Keyword(s):  
Blood Flow ◽  
Abdominal Wall ◽  
Anterior Abdominal Wall ◽  
Main Group ◽  
Control Group ◽  
Entire Study ◽  
Doppler Flowmetry ◽  
Significant Difference ◽  
Simultaneous Operations ◽  
Ultrasonic Doppler Flowmetry

The aim: Of work is to determine changes in blood flow in the vessels of the anterior abdominal wall that occur after plastic surgeries in order to improve the results of operations and to develop new methods for the prevention of complications. Materials and methods: The study was conducted in 132 patients. Patients were divided into 2 groups: main group 64 and control group 68 patients. Main group has patients who underwent abdominoplasty in combination with liposuction; control group has patients who underwent abdominoplasty without liposuction. In both groups we make different simultaneous operations. Laser Doppler Flowmetry and Ultrasonic Doppler Flowmetry were performed to determine the blood flow indices in the flaps. Results: Liposuction volumes averaged 3.57 ± 0.74 liters of lipoaspirate. In the main group there were totaly 4 complications, in the control group complications developed in 9 patients. Comparing daily indicators between the two groups, no statistically significant difference in the dynamics of MI changes was found during the entire study period (p = 0.767). Increase in caliber of vessels, on average, from 1.55 ± 0.8 mm in the preoperative period to 1.68 ± 0.75 mm on the 14th day of the postoperative period was statistically significant (p < 0.05). Conclusions: The combination of abdominoplasty with liposuction and simultaneous operations does not lead to greater development of complications and allows to achieve good aesthetic results.

State of uterine blood flow in women of reproductive age with endometrial hyperplasia

2016 ◽  
pp. 141-143
Author(s):  
V.G. Dubinina ◽  
◽  
K.M. Vizir ◽  
Keyword(s):  
Blood Flow ◽  
Pulsatility Index ◽  
Uterine Artery ◽  
Endometrial Hyperplasia ◽  
Color Doppler ◽  
Reproductive Period ◽  
Control Group ◽  
Uterine Blood Flow ◽  
Resistivity Index ◽  
Significant Difference

The objective: to assess the state of uterine blood flow in endometrial hyperplasia in women of reproductive period. Patients and methods. 130 patients (n=100 – the main group; n=30 – control group) aged 18-49 years with endometrial hyperplasia were examined. All the women underwent 2D transvaginal echography and color Doppler mapping. The angle-independent indices (pulsatility index, resistivity index, diastolic/systolic ratio) of blood flow were determined in the uterine, arcuate, radial, basal and spiral arteries. Results. There was no significant difference in the indices of blood flow of the right uterine artery, arcuate, radial, basal arteries among patients and control group. Among women with endometrial hyperplasia pulsatility index of the left uterine artery amounted to – 2.11, resistivity index – 0.88, and the diastolic/systolic ratio – 5.45, in women of the control group – 2.34, 1.01 and 7.50, respectively. Only among patients with endometrial hyperplastic process was registered blood flow in the spiral arteries. Conclusion. The use of color Doppler mapping is appropriate, because registration of intraendometrial blood flow allows an endometrial hyperplastic process to be diagnosed with a high degree of confidence. Key words: endometrial hyperplasia, reproductive period, color Doppler mapping, intraendometrial blood flow, pulsatility index, resistivity index, diastolic/systolic ratio.

Renal Blood Flow in Twins

1998 ◽  
Vol 47 (3-4) ◽  
pp. 161-169
Author(s):  
M. K. Kornacka ◽  
E. Burzyńska ◽  
J. Gadzinowski
Keyword(s):  
Blood Flow ◽  
Renal Blood Flow ◽  
Gestational Age ◽  
Clinical Symptoms ◽  
Mean Value ◽  
Control Group ◽  
Left Renal Artery ◽  
Mean Velocity ◽  
Significant Difference ◽  
And Control

AbstractThe aim of this preliminary study was the estimation of renal blood flow in 16 premature newborns from twin pregnancies with mean body weight 1270 g and mean gestational age 29 weeks.In control group we have 16 singleton newborns with mean gestational age 29 weeks and mean birth weight 1240 g. In both intervention and control group we have the similar clinical symptoms. The renal blood flow was carried out in the first day of life with the Acuson 128 XP Colour Doppler using the 6 and 7 MHz linear transducer. The renal blood flow parameters-PI, RI, Vmax, Vmin Vmean were measured in right and left renal arteries in theirs courses from the aorta to the renal hilus, by color sinal. In the investigation group the mean value of RI in right and left renal artery was 0,88. Mean PI in right vessel was 1,67 and in left 1,56. Mean V min in right and in left artery was 0,03 and mean V max in right artery was 0,34 and in left 0,33. Mean value of mean velocity in right vessels was 0,18 and in left 0,19.In control group we observed in right artery mean value of PI 1,74 and in left 1,6. Mean RI was 0,86 and 0,86 in right vessel in left vessel. Mean V min was 0,05 in right and 0,04 in left artery. Mean V max was 0,37 in right and 0,34 in left artery. Mean value of V mean was 0,19 in right artery and 0,18 in left artery.Using the student, Mann-Whitney and Shapiro-Wilk tests we have not observed statistically significant difference of Doppler parameters between control and investigation group and between the left and right artery. Although in newborns with broad PDA we noted significant higher value of RI (0,97, 0,98) than in newborns without PDA (0,78, 0,81).

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