Harnessing C–O Bonds in Stereoselective Cross-Coupling and Cross-Electrophile Coupling Reactions
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AbstractWe discuss our laboratory’s research in the activation of alcohol derivatives in cross-coupling and cross-electrophile coupling reactions. Our developed methods enable the use of secondary alcohols to afford tertiary stereogenic centers, which we applied to the synthesis of pharmaceutically relevant compounds and substructures. We first discuss the synthesis of bioactive compounds through stereospecific Kumada cross-coupling reactions and follow this with a discussion on the development of our stereoselective cross-electrophile coupling reaction to synthesize cyclopropanes.1 Introduction2 Cross-Coupling Reactions3 Cross-Electrophile Coupling Reactions4 Conclusion
2020 ◽
2018 ◽
Vol 16
(33)
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pp. 6017-6024
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2018 ◽
Vol 14
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pp. 1871-1884
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2017 ◽
Vol 15
(27)
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pp. 5805-5810
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2018 ◽
Vol 16
(43)
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pp. 8106-8114
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