Rapid Assembly of Oligosaccharides by Using a Hydrophobic Tag-Assisted Liquid-Phase Method
Keyword(s):
A 3,5-didocosyloxybenzyl alcohol tag that was introduced at the anomeric position of the carbohydrate acceptor was applied in the assembly of a pentasaccharide. The intrinsic high solubility in nonpolar solvent and precipitation properties in polar solvent are crucial features of this tag. Thus, rapid and simple precipitation-centrifugation can be conducted throughout the synthetic route at each step to ease work-up and purification processes, and reduce the amount of solvent required. This method provides an efficient, environmental-friendly, and economical approach to synthesize complex oligosaccharides.
1982 ◽
Vol 47
(7)
◽
pp. 1884-1892
2011 ◽
Vol 84-85
◽
pp. 514-518
Keyword(s):
Keyword(s):
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1996 ◽
Vol 35
(Part 1, No. 9A)
◽
pp. 4738-4742
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