scholarly journals Maternal Metabolic Biomarkers are Associated with Obesity and Excess Gestational Weight Gain

2020 ◽  
Author(s):  
Kathleen M. Antony ◽  
Mona Romezi ◽  
Kourtnee Lindgren ◽  
Kristen B. Mitchell ◽  
Susan F. Venable ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
Peptide Yy ◽  
Maternal Serum ◽  
C Peptide ◽  
Gestational Weight ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Metabolic Biomarkers

Abstract Objective The purpose of this study was to evaluate the independent contribution of maternal obesity and gestational weight gain (GWG) in excess of the Institute of Medicine's guidelines on levels of maternal serum inflammatory and metabolic measures. Study Design Banked maternal serum samples from 120 subjects with documented prepregnancy or first trimester body mass index (BMI) were utilized for analyte analyses. Validated, BMI-specific formulas were utilized to categorize GWG as either insufficient, at goal or excess based on the Institute of Medicine guidelines with gestational age adjustments. Serum was analyzed for known inflammatory or metabolic pathway intermediates using the Luminex xMap system with the MILLIPLEX Human Metabolic Hormone Magnetic Bead Panel. Measured analytes included interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-α and metabolic markers amylin, c-peptide, ghrelin, gastric inhibitory polypeptide, glucagon-like peptide-1, glucagon, insulin, leptin, pancreatic polypeptide, and peptide YY. Kruskal–Wallis ANOVA and Pearson's correlation coefficients were calculated for each marker. Results C-peptide, insulin, and leptin all varied significantly with both obesity and GWG while glucagon-like peptide-1 varied by BMI but not GWG. These analytes covaried with other metabolic analytes, but not with inflammatory analytes. Conclusion Maternal metabolic biomarkers at delivery vary significantly with both obesity and GWG. Taken together, these findings suggest that GWG (with and without comorbid obesity) is an important mediator of measurable metabolites in pregnancy but is not necessarily accompanied by inflammatory measures in serum. These findings are consistent with GWG being an independent risk factor for metabolic disturbances during pregnancy.

scholarly journals Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes

2018 ◽  
Vol 47 (2) ◽  
pp. 417-426 ◽  
Author(s):  
Maria C Magnus ◽  
Sjurdur F Olsen ◽  
Charlotta Granstrom ◽  
Nicolai A Lund-Blix ◽  
Jannet Svensson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
Gestational Weight

scholarly journals Impact of maternal obesity on pregnancy course and maternal and perinatal complications

2020 ◽  
Vol 71 (3) ◽  
pp. 54-58
Author(s):  
Milan Lacković
Keyword(s):  
Risk Factors ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Pregnancy Complications ◽  
Maternal Obesity ◽  
Overweight And Obesity ◽  
Perinatal Complications ◽  
Anthropometric Parameter ◽  
Gestational Weight ◽  
Excessive Gestational Weight Gain

 The prevalence of obesity and obesity-related health problems is increasing worldwide, especially among woman and man of reproductive age and obesity is designated as one of the most important global health threats in 21st century.  Pregnancy in obese woman is considered as a high-risk pregnancy. Pre-pregnancy obesity and excessive gestational weight gain (GWG) are distinct risk factors with differing associated adverse outcomes, but they could also carry a cumulative negative impact on pregnancy course. Pre-pregnancy obesity is the anthropometric parameter most strongly correlated with perinatal complications. Maternal complications following obesity include antepartum, intrapartum and postpartum complications, such as pregnancy related hypertension, preeclampsia, gestational diabetes mellitus, preterm birth, venous thromboembolism, labor dystocia, labor induction, instrumental and cesarean delivery. Fetal complications related to maternal obesity might include increased prevalence of congenital anomalies, growth abnormalities, prematurity and stillbirth. Pre- pregnancy overweight and obesity is a potentially modifiable risk factor compromising pregnancy outcome. Among all complications that might arise during pregnancy and that could not be predicted and therefore prevented, pre- pregnancy overweight and obesity management control can significantly reduce potential pregnancy complications. Pre-conceptual counseling should provide in a timely manner awareness of this arising medical condition and provide risk reduction of complications following pre- pregnancy obesity and excessive GWG  obesity, pre-pregnancy obesity, excessive gestational weight gain, pregnancy risk factors, pregnancy complications  

scholarly journals Maternal obesity and gestational weight gain: associations with maternal and infant outcomes

2018 ◽  
Vol 77 (OCE3) ◽  
Author(s):  
L. Cassidy ◽  
M.S. Mulhern ◽  
R.M. Alhomaid ◽  
M.B.E. Livingstone ◽  
J.C. Abayomi ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
Infant Outcomes ◽  
Gestational Weight ◽  
Maternal And Infant Outcomes

Maternal obesity, gestational weight gain and childhood cardiac outcomes: role of childhood body mass index

2016 ◽  
Vol 40 (7) ◽  
pp. 1070-1078 ◽  
Author(s):  
L Toemen ◽  
O Gishti ◽  
L van Osch-Gevers ◽  
E A P Steegers ◽  
W A Helbing ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Body Mass ◽  
Maternal Obesity ◽  
Gestational Weight ◽  
Cardiac Outcomes ◽  
Childhood Body Mass Index

Maternal Obesity and Gestational Weight Gain in Rural Versus Urban Dwelling Women in South Carolina

2012 ◽  
Vol 29 (1) ◽  
pp. 1-11 ◽  
Author(s):  
Alexa Gallagher ◽  
Jihong Liu ◽  
Janice C. Probst ◽  
Amy B. Martin ◽  
Jeffrey W. Hall
Keyword(s):  
South Carolina ◽  
Weight Gain ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
Gestational Weight

scholarly journals Gestational weight gain and long-term maternal obesity risk

Epidemiology ◽  
2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Franya Hutchins ◽  
Robert Krafty ◽  
Samar R El Khoudary ◽  
Janet Catov ◽  
Alicia Colvin ◽  
...  
Keyword(s):  
Weight Gain ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
Obesity Risk ◽  
Gestational Weight

scholarly journals Maternal Obesity and Its Adverse Effect on Maternal and Fetal Health

2021 ◽  
pp. 27-42
Author(s):  
Zahraa M. Lutfy ◽  
Ayman S. Dawood ◽  
Adel E. Al Gergawy ◽  
Mustafa Z. Mustafa
Keyword(s):  
Weight Gain ◽  
Early Detection ◽  
Gestational Weight Gain ◽  
Maternal Obesity ◽  
High Energy ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Fetal Health ◽  
Gestational Weight ◽  
Excessive Gestational Weight Gain

Background: The increasing prevalence of obesity worldwide has prompted the World Health Organization (WHO) to designate obesity as one of the most important global health threats. The epidemic is especially pronounced in women of reproductive age. Prepregnancy obesity is an independent risk factor for maternal and neonatal morbidity and mortality. The origin of this epidemic is unhealthy lifestyle – high energy and high-fat diet and physical inactivity. During periconceptual period and pregnancy, the composition of a woman’s diet is of particular importance, as it may influence the pregnancy, the delivery and the health of the mother and the infant later on, so an excessive gestational weight gain (GWG) is not recommended. The aim of our study is to clarify the complications related to excess prepregnancy body weight on maternal and fetal health. Methods: Hundred obese pregnant women with BMI (30-40 Kg/m2) measured at first trimester were prospectively enrolled into this study. Routine blood pressures, random blood sugar measuring and ultrasonographic follow up are required during pregnancy for early detection of any complications related to maternal obesity and excessive gestational weight gain (GWG). Results: cases statistically evaluated in these study were 100 pregnant females with mean age 27.34 years + 5 years SD and mean BMI 32.97 Kg/m2 + 2.92 Kg/m2 SD. Denoting in our study, the effect of maternal obesity om maternal and fetal health. Conclusion: A causal relationship between the prepregnancy BMI and obstetric complications is proven. Weight management is important for every women of reproductive age. Thus, medical Practice must consider these complications by providing early detection and management to improve both maternal and neonatal outcome.

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