Diagnostic Value of Cytokines and C-reactive Protein in the First 24 Hours of Neonatal Sepsis

2003 ◽  
Vol 20 (8) ◽  
pp. 491-502 ◽  
Keyword(s):  
Neonatal Sepsis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

Evaluation of Microbiologic and Hematologic Parameters and E-Selectin as Early Predictors for Outcome of Neonatal Sepsis

2009 ◽  
Vol 133 (8) ◽  
pp. 1291-1296 ◽  
Author(s):  
Maysaa El Sayed Zaki ◽  
Hesham El Sayed
Keyword(s):  
Neonatal Sepsis ◽  
Neonatal Intensive Care ◽  
Newborn Infants ◽  
Prognostic Indicator ◽  
Diagnostic Value ◽  
Total Leukocyte Count ◽  
C Reactive Protein ◽  
Gram Negative ◽  
Reactive Protein ◽  
Early Predictors

Abstract Context.—Early diagnosis of neonatal sepsis is mandatory. Various markers are used to diagnose the condition. Objective.—To evaluate the diagnostic value of various clinical data and hematologic parameters, such as total leukocyte count, absolute neutrophil count, immature to total neutrophil ratio, and soluble E-selectin (sE-selectin) in identification and outcome of neonatal sepsis. Design.—Newborn infants with a clinical diagnosis of sepsis in the neonatal intensive care unit at Mansoura University Children's Hospital during the period between July 2007 and December 2007 were eligible for study. In addition, 30 healthy neonates were included in the study. Complete hematologic and microbiologic laboratory investigations were performed, and serum E-selectin was measured. Results.—Plasma sE-selectin levels were significantly higher (P < .001) in infected infants (mean [SD], 156.9 [77.0] ng/mL) than in noninfected (mean [SD], 88.8 [47.1] ng/mL) and healthy infants (mean [SD], 8.67 [3.74] ng/ mL). Infants with gram-negative sepsis had higher sE-selectin levels than did those with gram-positive sepsis (P = .04). C-reactive protein was the best laboratory test for diagnosis of neonatal sepsis, with an overall sensitivity and specificity of 86% and 97%, respectively. Performing sE-selectin with C-reactive protein or immature to total ratio tests increased the specificity, but reduced the sensitivity, of the tests for the determination of neonatal sepsis. Plasma sE-selectin levels were higher in nonsurvivors than in survivors (P = .01) and were higher in those with hemodynamic dysfunction than in those without hemodynamic dysfunction (P < .001). Conclusions.—We conclude that plasma sE-selectin levels are elevated in neonatal sepsis. Significant elevation was associated with gram-negative sepsis. Plasma sE-selectin had low diagnostic value when used alone or in combination with other tests; however, it can be used as a prognostic indicator for the outcome of neonatal sepsis.

Diagnostic Value of Urine sTREM-1 and Urine C-reactive Protein for Infants with Late Onset Neonatal Sepsis

2019 ◽  
Vol 15 (02) ◽  
pp. 072-078
Author(s):  
Senem Alkan Ozdemir ◽  
Ruya Colak ◽  
Ezgi Yangin Ergon ◽  
Sebnem Calkavur
Keyword(s):  
Neonatal Sepsis ◽  
Predictive Value ◽  
Late Onset ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Late Onset Sepsis ◽  
Noninvasive Markers ◽  
Serum Crp ◽  
Sepsis Detection

Abstract Objective Noninvasive markers have been increasingly used as a diagnostic marker for sepsis detection and monitoring of the disease. The aim of this observational, prospective pilot study was to investigate the diagnostic performance of urinary soluble triggering receptor expressed on myeloid cells (sTREM-1) and urine C-reactive protein (CRP) levels in the late onset neonatal sepsis and to compare them with serum CRP levels. Materials and Methods Sixty-six infants with clinical sepsis were included. Urine sTREM-1 and urine CRP were collected at the diagnosis of late-onset sepsis. All laboratory investigations were also noted from the infants. Results There were no significant differences between characteristics of the infants. Culture-positive neonates had significantly higher urine sTREM-1 than culture-negative neonates (p < 0.001). Using a cut-off point for urine sTREM-1 of 129 pg/mL, the sensitivity was 0.63, the specificity was 0.84, positive predictive value was 0.80, negative predictive value was 0.70. Urine sTREM-1 and urine CRP were recollected on the seventh day of sepsis treatment and it was found that the levels of sTREM-1 and CRP decreased. Conclusion This is the first study in the literature which evaluates the place of urine sTREM-1 and urine CRP in the diagnosis of neonatal sepsis. Urine sTREM-1 and urine CRP may be useful in the diagnosis of sepsis and in evaluating the effect of antibiotic treatment.

Diagnostic value of resistin and visfatin, in comparison with C-reactive protein, procalcitonin and interleukin-6 in neonatal sepsis

2011 ◽  
Vol 22 (2) ◽  
pp. 113-117 ◽  
Author(s):  
Ferhat Cekmez ◽  
Fuat Emre Canpolat ◽  
Merih Çetinkaya ◽  
Seçil Aydinöz ◽  
Gokhan Aydemir ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Early Onset Neonatal Sepsis; Diagnostic Value of Some Laboratory Tests

2018 ◽  
Vol 4 (1) ◽  
pp. 1109-1114
Author(s):  
Tania Licona ◽  
German Fajardo ◽  
Rubén Ferrera ◽  
Alejandra Mazariegos
Keyword(s):  
Blood Culture ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Laboratory Tests ◽  
Calculated Data ◽  
Clinical Situation ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Control Study

Early Onset Neonatal Sepsis (EONS) is a clinical situation resulting from the invasion and proliferation of bacteria, fungi or viruses in the newborn (NB) bloodstream, which occurs within the first 72 hours of life. To determine the diagnostic usefulness of laboratory tests performed on infants with suspicion of early neonatal sepsis at the Santa Barbara Integrated Hospital, Honduras. A case-control study was carried out during 2016; the cases were 20 infants with early onset neonatal sepsis, and the controls were 40 infants who were admitted as potentially septic, but the blood culture result was negative. Sensitivity, specificity, positive predictive value (PPV) and negative (NPV) of leukocytosis, platelets, initial C-reactive protein (CRP) and control were calculated. Data were analyzed with SPSS version 19. It was found that 17 (28.3 %) NB were women and 43 (71.7 %) were men. The VPP of the initial PCR was 5 %, increasing to 85 % in the control study. The isolated microorganism was enterobacter in 6 (30 %) of the RNs. Of the 23 (38.3 %) neonates who presented complications; 11 (48 %) had positive blood culture and 12 (52 %) had negative blood cultures. The discharge condition was medical discharge in 55 (92 %) and referred to a more complex hospital 5 (8 %) of the neonates. The VPP of the C-reactive protein increases considerably when doing a laboratory control,between 24-48 hours.

DIAGNOSTIC VALUE OF LABORATORY MARKERS OF NEONATAL SEPSIS IN PREMATURE INFANTS

2021 ◽  
Vol 100 (1) ◽  
pp. 95-100
Author(s):  
G.V. Kulizhnikov ◽  
◽  
E.G. Furman ◽  
A.V. Nikolenko ◽  
◽  
...  
Keyword(s):  
Premature Infants ◽  
Neonatal Sepsis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Diagnostic Significance ◽  
Reactive Protein ◽  
Advantages And Disadvantages ◽  
Negative Results ◽  
Laboratory Markers ◽  
Sensitivity Specificity

Neonatal sepsis (NS) is the leading cause of mortality in premature newborns. It is a difficult diagnostic task for clinicians. This article provides a review of the literature on laboratory markers of NS. The latest methods for the diagnosis of sepsis in premature infants in various studies are considered in the article. The results of studying the diagnostic value of a general blood test, cytokines, C-reactive protein, procalcitonin, prespepsin, microRNA polymorphism, bacterial blood culture, their advantages and disadvantages, as well as diagnostic significance – sensitivity, specificity, prognostic value of positive and negative results are presented.

scholarly journals Diagnostic value of C-reactive protein in neonatal sepsis: A meta-analysis

2016 ◽  
Vol 14 (2) ◽  
pp. 100-108 ◽  
Author(s):  
Liyun Xu ◽  
Qiubo Li ◽  
Zongju Mo ◽  
Pengfei You
Keyword(s):  
Neonatal Sepsis ◽  
Meta Analysis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals C-Reactive Protein, Interleukin-6, and Procalcitonin in the Immediate Postnatal Period: Influence of Illness Severity, Risk Status, Antenatal and Perinatal Complications, and Infection

2003 ◽  
Vol 49 (1) ◽  
pp. 60-68 ◽  
Author(s):  
Claudio Chiesa ◽  
Gabriella Pellegrini ◽  
Alessandra Panero ◽  
John F Osborn ◽  
Fabrizio Signore ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Neonatal Sepsis ◽  
Early Onset ◽  
Neonatal Infection ◽  
Diagnostic Value ◽  
Illness Severity ◽  
Perinatal Complications ◽  
C Reactive Protein ◽  
Risk Status ◽  
Reactive Protein

Abstract Background: Studies of the diagnostic accuracy of most laboratory tests for early-onset neonatal sepsis have yielded variable results. We investigated whether some of this variation might be attributable to differences in population baseline severity and risk status as well as to specific ante- and perinatal variables, independent of the presence of neonatal infection. Methods: The Score for Neonatal Acute Physiology (SNAP) was used to define illness severity, with SNAP Perinatal Extension (SNAP-PE) used to define the combined physiologic and perinatal mortality risk. A total of 134 ill newborns (19 with early-onset infection and 115 with no infection) were available for simultaneous analysis of the association of SNAP, SNAP-PE, and maternal and perinatal variables with C-reactive protein (CRP), interleukin-6 (IL-6), and procalcitonin (PCT) concentrations at birth and at 24 and 48 h of life. Results: Early-onset neonatal infection was associated with significant increases in CRP, IL-6, and PCT concentrations at all three time points, independent of illness severity. However, among babies without infection, higher SNAP and SNAP-PE scores were associated with higher IL-6 concentrations at birth. Certain maternal or perinatal variables altered IL-6 and PCT values in the infected as well as in the uninfected neonates. However, if different cutoff points were used at any of the three neonatal ages, PCT sensitivity and specificity were greater than those of CRP or IL-6. Conclusions: Illness severity and risk status are unlikely to interfere with the use of CRP and PCT for detection of early-onset neonatal sepsis. In contrast, the diagnostic value of IL-6 at birth may be altered by physiologic severity and risk indexes. The reliability of CRP, IL-6, and PCT for the diagnosis of early-onset neonatal infection requires specific cutoff values for each evaluation time point over the first 48 h of life.

Diagnostic value of soluble E-selectin and highly sensitive C-reactive protein as markers for neonatal sepsis

2014 ◽  
Vol 13 (2) ◽  
pp. 74-79
Author(s):  
Mohammad M. EL Bakry ◽  
Mohammad T. EL Sherbini ◽  
Mostafa M. EL Ahmady ◽  
Eman A. El Ghoroury ◽  
Azza M. Ahmad ◽  
...  
Keyword(s):  
Neonatal Sepsis ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Highly Sensitive ◽  
Soluble E Selectin

scholarly journals DIAGNOSTIC VALUE PARAMETERS OF ACUTE PHASE REACTANCES OF INFECTIOUS-INFLAMMATORY PROCESS IN DIAGNOSTICS OF EARLY NEONATAL SEPSIS

2018 ◽  
Vol 5 ◽  
pp. 20-27
Author(s):  
Leonid Bezrukov ◽  
Olena Koloskova ◽  
Olena Vlasova
Keyword(s):  
Neonatal Sepsis ◽  
Inflammatory Process ◽  
Clinical Signs ◽  
Early Period ◽  
Neonatal Infection ◽  
Diagnostic Value ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Low Concentrations ◽  
Susceptibility Factors

An advanced progress of clinical neonatology in recent years has enabled to achieve considerable success in newborn management with due respect to both medical treatment and general care, especially in the group of neonates with low body weight at birth. At the same time, neonatal sepsis in the early period still predetermine sickness and mortality of newborns. Material and methods. Clinical-paraclinical indices with detection of diagnostic value of C-reactive protein and interleukins-6 and 8 were evaluated in 100 neonates with available susceptibility factors to early neonatal infection from mother’s side and clinical signs of organ dysfunction in neonates with precautions of generalized infectious-inflammatory process at the end of their first day of life. Results. The data obtained substantiate that low concentrations of IL-6 and IL-8 prevail, and therefore the mentioned mediators hardly can be used to verify early neonatal infection. In the majority of children C-reactive protein elevated the concentration of 10.0 mg/L which is traditionally considered to be a discriminant as to the verification of an infectious process in newborns. Conclusions. None of the clinical signs associated with infectious-inflammatory process in newborns in the first two days of their life enabled to verify reliably availability of systemic bacterial infection.

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