Structure Elucidation and Biological Activity of Secondary Metabolites from Marine Red and Brown Algae

Macroalgae produce a wide range of monoterpenes as secondary metabolites of mevalonate (MVA) and/or methylerythritol phosphate (MEP) pathway (often including haloperoxidase action). Great biodiversity of macroalgal monoterpenes was reported including acyclic, monocyclic, and bicyclic structures. Halogenated monoterpenes exhibited significant biological activity (e.g., anticancer, antiplasmodial, and insecticidal) that is influenced by the number of present halogens (higher halogen content is preferable, especially bromine) and their position within the monoterpene skeleton. In distinction from the existing reviews, the present review provides novelty with respect to: (a) exclusively monoterpenes from red macroalgae are targeted; (b) biosynthesis, isolation, and analysis, as well as bioactivity of monoterpenes are represented; (c) the methods of their isolation, analysis, and structure elucidation are summarized; (d) the bioactivity of macroalgal monoterpenes is systematically presented with emphasis on anticancer activity; (e) the literature references were updated.

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Bioactive secondary metabolites from new terrestrial Streptomyces sp. TN82 strain: Isolation, structure elucidation and biological activity

Medicinal Chemistry Research ◽

10.1007/s00044-017-2130-4 ◽

2018 ◽

Vol 27 (4) ◽

pp. 1085-1092 ◽

Cited By ~ 4

Author(s):

Imene Zendah El Euch ◽

Marcel Frese ◽

Norbert Sewald ◽

Slim Smaoui ◽

Mohamed Shaaban ◽

...

Keyword(s):

Biological Activity ◽

Secondary Metabolites ◽

Structure Elucidation ◽

Streptomyces Sp ◽

Strain Isolation ◽

Bioactive Secondary Metabolites

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Isolation and Structure Elucidation of Secondary Metabolites from Mangrove Endophytic Fungus Penicillium sp. (ZZF29#)

ACTA AGRONOMICA SINICA ◽

10.3724/sp.j.1095.2012.00438 ◽

2012 ◽

Vol 29 (6) ◽

pp. 727

Author(s):

Shangde LI ◽

Meiyan WEI ◽

Zhihua LI ◽

Zhigang SHE ◽

Yongcheng LIN

Keyword(s):

Secondary Metabolites ◽

Endophytic Fungus ◽

Structure Elucidation ◽

Penicillium Sp ◽

Mangrove Endophytic Fungus

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New Haloterpenes from the Marine Red Alga Laurencia papillosa: Structure Elucidation and Biological Activity

Marine Drugs ◽

10.3390/md19010035 ◽

2021 ◽

Vol 19 (1) ◽

pp. 35

Author(s):

Mohamed Shaaban ◽

Ghada S. E. Abou-El-Wafa ◽

Christopher Golz ◽

Hartmut Laatsch

Keyword(s):

Biological Activity ◽

Crude Extract ◽

Structure Elucidation ◽

Antimicrobial Activities ◽

Red Alga ◽

Spectroscopic Methods ◽

X Ray Diffraction ◽

X Ray ◽

Chemical Structures ◽

Terpene Derivatives

Analysis of the air-dried marine red alga Laurencia papillosa, collected near Ras-Bakr at the Suez gulf (Red Sea) in Egypt delivered five new halogenated terpene derivatives: aplysiolic acid (1), 7-acetyl-aplysiol (2), aplysiol-7-one (3), 11,14-dihydroaplysia-5,11,14,15-tetrol (5a), and a new maneonene derivative 6, named 5-epi-maneolactone. The chemical structures of these metabolites were characterized employing spectroscopic methods, and the relative and absolute configurations were determined by comparison of experimental and ab initio-calculated NMR, NOE, ECD, and ORD data, and by X-ray diffraction of 2 and 6. The antimicrobial activities of the crude extract and compounds 1–3, 5a and 6 were studied.

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Chemical Diversity and Biological Activity of Secondary Metabolites from Soft Coral Genus Sinularia since 2013

Marine Drugs ◽

10.3390/md19060335 ◽

2021 ◽

Vol 19 (6) ◽

pp. 335

Author(s):

Xia Yan ◽

Jing Liu ◽

Xue Leng ◽

Han Ouyang

Keyword(s):

Biological Activity ◽

Secondary Metabolites ◽

Coral Species ◽

Soft Coral ◽

Biological Activities ◽

Vital Role ◽

Chemical Diversity ◽

Pharmacological Activities ◽

Lead Compounds ◽

Coral Genus

Sinularia is one of the conspicuous soft coral species widely distributed in the world’s oceans at a depth of about 12 m. Secondary metabolites from the genus Sinularia show great chemical diversity. More than 700 secondary metabolites have been reported to date, including terpenoids, norterpenoids, steroids/steroidal glycosides, and other types. They showed a broad range of potent biological activities. There were detailed reviews on the terpenoids from Sinularia in 2013, and now, it still plays a vital role in the innovation of lead compounds for drug development. The structures, names, and pharmacological activities of compounds isolated from the genus Sinularia from 2013 to March 2021 are summarized in this review.

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Isolation, Structure Elucidation, and Biological Activity of a New Alkaloid from Zanthoxylum rhetsa

Natural Product Communications ◽

10.1177/1934578x1100601110 ◽

2011 ◽

Vol 6 (11) ◽

pp. 1934578X1100601

Author(s):

Karsten Krohn ◽

Stephan Cludius-Brandt ◽

Barbara Schulz ◽

Mambatta Sreelekha ◽

Pottachola Mohamed Shafi

Keyword(s):

Biological Activity ◽

Carboxylic Acid ◽

Medicinal Plant ◽

Plant Extract ◽

Structure Elucidation ◽

Biologically Active ◽

Reduction Product ◽

Pharmacological Properties ◽

Evergreen Tree

Several biologically active alkaloids (1-4, 6), including a new quinazoline-6-carboxylic acid (1), were isolated from the medicinal plant Zanthoxylum rhetsa, an evergreen tree, native to subtropical areas. Whereas the pharmacological properties of the plant extract and single constituents have been widely tested, we now show that all of the metabolites have antialgal activities, all but 6 are antibacterial, and 6 and the reduction product 5 (derived from 4) are also antifungal.

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