scholarly journals Update on Monoterpenes from Red Macroalgae: Isolation, Analysis, and Bioactivity

Marine Drugs ◽  
2019 ◽  
Vol 17 (9) ◽  
pp. 537
Author(s):  
Ana-Marija Cikoš ◽  
Mladenka Jurin ◽  
Rozelindra Čož-Rakovac ◽  
Stela Jokić ◽  
Igor Jerković
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Anticancer Activity ◽  
Structure Elucidation ◽  
Present Review ◽  
Red Macroalgae ◽  
Methylerythritol Phosphate ◽  
Halogenated Monoterpenes ◽  
Wide Range ◽  
Halogen Content

Macroalgae produce a wide range of monoterpenes as secondary metabolites of mevalonate (MVA) and/or methylerythritol phosphate (MEP) pathway (often including haloperoxidase action). Great biodiversity of macroalgal monoterpenes was reported including acyclic, monocyclic, and bicyclic structures. Halogenated monoterpenes exhibited significant biological activity (e.g., anticancer, antiplasmodial, and insecticidal) that is influenced by the number of present halogens (higher halogen content is preferable, especially bromine) and their position within the monoterpene skeleton. In distinction from the existing reviews, the present review provides novelty with respect to: (a) exclusively monoterpenes from red macroalgae are targeted; (b) biosynthesis, isolation, and analysis, as well as bioactivity of monoterpenes are represented; (c) the methods of their isolation, analysis, and structure elucidation are summarized; (d) the bioactivity of macroalgal monoterpenes is systematically presented with emphasis on anticancer activity; (e) the literature references were updated.

Enzymes as a Reservoir of Host Defence Peptides

2020 ◽  
Vol 20 (14) ◽  
pp. 1310-1323
Author(s):  
Andrea Bosso ◽  
Antimo Di Maro ◽  
Valeria Cafaro ◽  
Alberto Di Donato ◽  
Eugenio Notomista ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Biological Activity ◽  
Internal Structure ◽  
Catalytic Properties ◽  
Cellular Responses ◽  
Host Defence ◽  
Present Review ◽  
Active Peptides ◽  
Wide Range

Host defence peptides (HDPs) are powerful modulators of cellular responses to various types of insults caused by pathogen agents. To date, a wide range of HDPs, from species of different kingdoms including bacteria, plant and animal with extreme diversity in structure and biological activity, have been described. Apart from a limited number of peptides ribosomally synthesized, a large number of promising and multifunctional HDPs have been identified within protein precursors, with properties not necessarily related to innate immunity, consolidating the fascinating hypothesis that proteins have a second or even multiple biological mission in the form of one or more bio-active peptides. Among these precursors, enzymes constitute certainly an interesting group, because most of them are mainly globular and characterized by a fine specific internal structure closely related to their catalytic properties and also because they are yet little considered as potential HDP releasing proteins. In this regard, the main aim of the present review is to describe a panel of HDPs, identified in all canonical classes of enzymes, and to provide a detailed description on hydrolases and their corresponding HDPs, as there seems to exist a striking link between these structurally sophisticated catalysts and their high content in cationic and amphipathic cryptic peptides.

Structure Elucidation and Biological Activity of Secondary Metabolites from Marine Red and Brown Algae

Planta Medica ◽  
1991 ◽  
Vol 57 (S 2) ◽  
pp. A5-A5 ◽  
Author(s):  
G. König ◽  
A. Wright ◽  
O. Sticher ◽  
K. Jurcic ◽  
F. Offermann ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Brown Algae ◽  
Structure Elucidation

Bioactive secondary metabolites from new terrestrial Streptomyces sp. TN82 strain: Isolation, structure elucidation and biological activity

2018 ◽  
Vol 27 (4) ◽  
pp. 1085-1092 ◽  
Author(s):  
Imene Zendah El Euch ◽  
Marcel Frese ◽  
Norbert Sewald ◽  
Slim Smaoui ◽  
Mohamed Shaaban ◽  
...  
Keyword(s):  
Biological Activity ◽  
Secondary Metabolites ◽  
Structure Elucidation ◽  
Streptomyces Sp ◽  
Strain Isolation ◽  
Bioactive Secondary Metabolites

scholarly journals The synthesis of angular heteroarenochromones based on 7-hydroxy-8-carbonylchromones

2017 ◽  
Vol 5 (2) ◽  
pp. 68-94 ◽  
Author(s):  
Tatyana Shokol ◽  
Oleg Lozinski ◽  
Natalia Gorbulenko ◽  
Volodymyr Khilya
Keyword(s):  
Biological Activity ◽  
Biological Activities ◽  
The Other ◽  
Present Review ◽  
Synthetic Analogues ◽  
Naturally Occurring ◽  
Other Hand ◽  
Wide Range

The present review highlights advanced strategies to the synthesis of the chromones annulated with O- and N-containing heterocycles at C(7)-C(8) bond. Due to the prevalence of such motives in different kinds of natural flavonoids and some alkaloids, fused chromones have attracted a great deal of attention so far. On the other hand a wide range of biological activities is displayed by the compounds of this type both among naturally occurring flavonoids and their synthetic analogues. 8-Carbonyl-7-hydroxychromones proved to be versatile synthones for the synthesis of angular hetarenochromones via approach of annulation of a heterocycle to the chromone core. It also addresses the question of the biological activity of naturally occurring and fused synthetic hetarenochromones.

scholarly journals Actinomycetes strain Streptomyces sp. Je 1-42: phylogenetic analysis, biological activity and secondary metabolite profile

2020 ◽  
Vol 27 ◽  
pp. 276-281
Author(s):  
S. I. Tistechok ◽  
Yu. R. Datsyuk ◽  
O. V. Fedorenko ◽  
O. M. Gromyko
Keyword(s):  
Phylogenetic Analysis ◽  
Antibacterial Activity ◽  
Biological Activity ◽  
Secondary Metabolites ◽  
Molecular Genetic ◽  
Bioactive Molecules ◽  
Microbial Culture ◽  
Genus Streptomyces ◽  
Streptomyces Sp ◽  
Wide Range

Aim. Screening of new natural bioactive molecules is one of the effective approach in combating multidrug-resistant pathogens and tumor cells. The aim of this work was to study the taxonomic characteristic, biological activity and secondary metabolites production of isolate Je 1-42 from the rhizosphere of Juniperus excelsa Bieb. Methods. Microbiological, molecular genetic, high performance liquid chromatography mass spectrometry and scanning electron microscopy methods were used in this work. Results. Based on a phylogenetic analysis of the 16S rRNA and gyrB gene sequences, microbiological and physiological characterization the isolate Je 1-42 has been affiliated to the genus Streptomyces. The isolate Je 1-42 showed a wide range of antibacterial activity. The antibiotics desertomycin A, kanchanamycin A, butylcycloheptylprodigiosine and spectinabilin were annotated in the Je 1-42 extract using dereplication analysis in the database DNP. Conclusions. Actinomycetes strain Streptomyces sp. Je 1-42 is an antagonist of gram-positive, gram-negative bacteria, fungi and produces antibiotics desertomycin A, canchanamycin A, butylcycloheptylprodigiozin, spectinabilin, which has a broad spectrum of antimicrobial activity. The production of these compounds obviously determines the ability of Je 1-42 to inhibit the growth of a wide range of bacteria and fungi. The strain of Streptomyces sp. Je 1-42 was deposited in the Microbial Culture Collection of Antibiotics Producers at Ivan Franko National University of Lviv (collection number Lv 1-042). Keywords: Streptomyces, secondary metabolites, antibacterial activity, phylogenetic analysis.

scholarly journals A Brief Review of Phenolic Compounds Identified from Plants: Their Extraction, Analysis, and Biological Activity

2022 ◽  
Vol 17 (1) ◽  
pp. 1934578X2110697
Author(s):  
Yuanyuan Zhang ◽  
Ping Cai ◽  
Guanghui Cheng ◽  
Yongqiang Zhang
Keyword(s):  
Biological Activity ◽  
Phenolic Compounds ◽  
Secondary Metabolites ◽  
Biological Activities ◽  
Research Direction ◽  
Analysis Methods ◽  
Wide Range ◽  
Different Types ◽  
The Future ◽  
Available Information

Phenolic compounds are the most abundant secondary metabolites in plants, showing a wide range of distinct biological activities, have received more and more attention in recent years. This review aims to gather and systematize available information on the phenolic compounds from plants by discussing different types of phenolic compounds, extraction, and analysis methods, with an emphasis on their potential biological activities. The research direction and problems that should be paid attention to in the future are also put forward to provide some references for the further study of phenolic compounds.

Researches on the Synthesis and Biological Activity of 1,2,4-tiadizoles-3,5-disubstituted using Ditiazolium Salts as Precursors

2008 ◽  
Vol 59 (1) ◽  
pp. 101-105
Author(s):  
Irina Zarafu ◽  
Lucia Veronica Ivan ◽  
Iuliana Harasim
Keyword(s):  
Biological Activity ◽  
Comparative Study ◽  
Anticancer Activity ◽  
Reaction Process ◽  
Physical Analysis ◽  
Ultrasound Exposure ◽  
Medium Activity ◽  
Antibacterial And Anticancer Activity

3,5-disubstituted-1,2,4-tiadiazoles with substituted-styril and heterocycle-vinyl were obtained by extending the method which implies the use of 3,5-disubstituted-1,2,4-ditiazolium salts as precursors [1-4]. A comparative study of the reaction process in the case of perchlorates, diacide phosphates, tribromides and 3,5-distyrile-dithiazolium triiodides, taken as etalon, was perfomed. Good yields were obtained when using perchlorates, phosphates and triiodides. The reaction was made by heating the reaction mixture and by ultrasound exposure. The structure of the compounds was confirmed by chemical and physical analysis and the data obtained were identical to those of 3,5-disubstituted-1,2,4-tiadiazoles obtained by another methods [5,6]. The biological (antibacterial and anticancer) activity of the synthesized compounds was tested and the results indicated a medium activity.

A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

2020 ◽  
Vol 24 (5) ◽  
pp. 473-486 ◽  
Author(s):  
Ligia S. da Silveira Pinto ◽  
Thatyana R. Alves Vasconcelos ◽  
Claudia Regina B. Gomes ◽  
Marcus Vinícius N. de Souza
Keyword(s):  
Side Effects ◽  
Anticancer Agents ◽  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Present Review ◽  
Pharmacological Properties ◽  
Important Group ◽  
Wide Range ◽  
Anti Inflammatory

Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

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