Increased carotid intima-media thickness in patients with ischaemic stroke is associated with systemic endothelial dysfunction and preclinical occlusive vascular disease

2007 ◽  
Vol 34 (S 2) ◽  
Author(s):  
M Rosenkranz ◽  
S Havemeister ◽  
AC Krützelmann ◽  
G Thomalla ◽  
C Gerloff
Keyword(s):  
Endothelial Dysfunction ◽  
Ischaemic Stroke ◽  
Vascular Disease ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
Occlusive Vascular Disease

Endothelial Dysfunction and Inflammatory Markers of Vascular Disease

2020 ◽  
Vol 19 (3) ◽  
pp. 243-249 ◽  
Author(s):  
Sevket Balta
Keyword(s):  
Endothelial Dysfunction ◽  
Vascular Disease ◽  
Inflammatory Markers ◽  
Vascular Diseases ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Non Invasive ◽  
Von Willebrand ◽  
The Relationship ◽  
Willebrand Factor

: Vascular diseases are the main reason for morbidity and mortality worldwide. As we know, the earlier phase of vascular diseases is endothelial dysfunction in humans, the endothelial tissues play an important role in inflammation, coagulation, and angiogenesis, via organizing ligand-receptor associations and the various mediators’ secretion. We can use many inflammatory non-invasive tests (flowmediated dilatation, epicedial fat thickness, carotid-intima media thickness, arterial stiffness and anklebrachial index) for assessing the endothelial function. In addition, many biomarkers (ischemia modified albumin, pentraxin-3, E-selectin, angiopoietin, endothelial cell specific molecule 1, asymmetrical dimethylarginine, von Willebrand factor, endothelial microparticles and endothelial progenitor cells) can be used to evaluate endothelial dysfunction. We have focused on the relationship between endothelial dysfunction and inflammatory markers of vascular disease in this review.

scholarly journals Endothelial dysfunction but not increased carotid intima-media thickness in young European women with endometriosis

2012 ◽  
Vol 27 (5) ◽  
pp. 1320-1326 ◽  
Author(s):  
L. Santoro ◽  
F. D'Onofrio ◽  
S. Campo ◽  
P. M. Ferraro ◽  
P. Tondi ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness ◽  
European Women

Endothelial Dysfunction, Carotid Intima-Media Thickness, and Accelerated Atherosclerosis in Rheumatoid Arthritis

2008 ◽  
Vol 38 (2) ◽  
pp. 67-70 ◽  
Author(s):  
Miguel A. Gonzalez-Gay ◽  
Carlos Gonzalez-Juanatey ◽  
Tomas R. Vazquez-Rodriguez ◽  
Javier Martin ◽  
Javier Llorca
Keyword(s):  
Rheumatoid Arthritis ◽  
Endothelial Dysfunction ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Accelerated Atherosclerosis ◽  
Media Thickness

Lipoprotein associations with endothelial dysfunction and carotid intima-media thickness in young people with Type 1 diabetes

2010 ◽  
Vol 213 (1) ◽  
pp. e2-e3
Author(s):  
Latika Sibal ◽  
Dermot Neely ◽  
Anne Jones ◽  
George Mitchell ◽  
Crispian Oates ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Endothelial Dysfunction ◽  
Young People ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals FLOW MEDIATED DILATION AND CAROTID INTIMA MEDIA THICKNESS IN PATIENTS WITH CHRONIC GASTRITIS ASSOCIATED WITH HELICOBACTER PYLORI INFECTION

2017 ◽  
Vol 54 (4) ◽  
pp. 300-304 ◽  
Author(s):  
Arezo JUDAKI ◽  
Siros NOROZI ◽  
Mohammad Reza Hafezi AHMADI ◽  
Samira Mis GHAVAM ◽  
Khairollah ASADOLLAHI ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Endothelial Dysfunction ◽  
Chronic Gastritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Control Group ◽  
Flow Mediated Dilation ◽  
Infection Group ◽  
Media Thickness ◽  
H Pylori

ABSTRACT BACKGROUND: Endothelial dysfunction is one of the early stages of vascular diseases. OBJECTIVE: The aim of this study was to investigate the endothelial dysfunction markers in patients with chronic gastritis associated with Helicobacter pylori (H. pylori) infection. METHODS: By a cross sectional study, basic and clinical information of 120 participants (40 patients with positive H. pylori infection, 40 patients with negative H. pylori infection and 40 healthy people) were analyzed. Carotid intima media thickness and flow-mediated dilation levels were measured in all patients and controls. Soluble vascular cell adhesion molecule-1 (sVCAM-1) and intercellular adhesion molecule-1 (ICAM-1) were measured with Elisa for all subjects. IgG level was assessed in chronic gastritis patients. RESULTS: The flow-mediated dilation level in patients with positive H. pylori infection (0.17%±0.09) was significantly lower than those with negative H. pylori infection (0.21% ±0.10, P<0.05) and compared to the control group (0.27% ±0.11, P<0.05). Carotid intima media thickness level in patients with positive H. pylori infection (0.58±0.13 mm) was significantly higher than those with negative H. pylori infection (0.48±0.32 mm, P<0.05) and compared to the control group (0.36±0.44mm, P<0.05). The mean level of sICAM-1 in positive H. pylori infection group (352.16±7.54 pg/mL) was higher than negative H. pylori infection group (332.64±8.75 pg/mL =0.75) and compared to the control group (236.32±12.43 pg/mL, P<0.05). A direct relationship was revealed between flow-mediated dilation and carotid intima media thickness changes and between sICAM-1 and sVCAM-1 associated with the level of H. pylori IgG in chronic gastritis. CONCLUSION: The levels of flow-mediated dilation, carotid intima media thickness and sICAM-1 were higher among patients with positive H. pylori infection. Patients with chronic gastritis associated with H. pylori infection are at risk of endothelial dysfunction due to flow-mediated dilation and carotid intima media thickness abnormalities and increased level of sICAM-1 and sVCAM-1.

scholarly journals Vascular function long term after Kawasaki disease: another piece of the puzzle?

2016 ◽  
Vol 27 (3) ◽  
pp. 488-497 ◽  
Author(s):  
Fátima F. Pinto ◽  
Inês Gomes ◽  
Petra Loureiro ◽  
Sérgio Laranjo ◽  
Ana T. Timóteo ◽  
...  
Keyword(s):  
Risk Factors ◽  
Endothelial Dysfunction ◽  
Kawasaki Disease ◽  
Vascular Function ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Cardiac Complications ◽  
Media Thickness ◽  
Coronary Lesions

AbstractBackgroundKawasaki disease is an acute systemic vasculitis. Cardiac complications are frequent and include endothelial dysfunction in patients with coronary anomalies. Thus far, endothelial dysfunction in patients with no coronary lesions is poorly understood. Our aim was to access the vascular function in adolescents and young adults long term after Kawasaki disease, but without coronary aneurysms or any other cardiac risk factors.MethodsWe carried out a single-centre prospective study in a Portuguese population. We evaluated two groups of subjects: (1) Kawasaki disease patients over 11 years of age, diagnosed >5 years ago, with no coronary lesions or any other risk factors for cardiovascular disease; (2) control group of individuals without cardiovascular risk factors. Patients and controls were clinically assessed. Endo-PAT and carotid intima-media thickness assessment were performed to determine vascular function.ResultsIn total, 43 Kawasaki disease patients were assessed and compared with 43 controls. Kawasaki disease patients presented a decreased reactive hyperaemia index compared with controls (1.59±0.45 versus 1.98±0.41; p<0.001). Augmentation index was similar in both groups (−4.5±7 versus −5±9%; p 0.6). The mean carotid intima-media thickness was not significantly increased in the Kawasaki disease group. There were no statistically significant changes with regard to laboratory data.ConclusionsChildren with Kawasaki disease may have long-term sequelae, even when there is no discernible coronary artery involvement in the acute stage of the disease. Further research is needed to assess whether known strategies to improve endothelial function would bring potential benefits to Kawasaki disease patients.

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