A Controlled Study of Short-Term Prednisone Treatment in Adults with Membranous Nephropathy

Background The analgesic activity of morphine-6-glucuronide (M-6-G) is well recognized for its contribution to the effects of morphine and its possible use as an opioid analgesic with a wider therapeutic range than morphine. The present study attempted to quantify the relative contribution of M-6-G to analgesia observed after systemic administration of morphine. Methods In a placebo-controlled, sixfold crossover study in 20 healthy men, the effects of M-6-G were assessed at steady-state plasma concentrations of M-6-G identical to and two and three times higher than those measured after administration of morphine. Morphine and M-6-G were administered as an intravenous bolus followed by infusion over 4 h. Dosage A was M-6-G-bolus of 0.015 mg/kg plus infusion of 0.0072 mg x kg(-1) x h(-1). Dosage B was M-6-G-bolus of 0.029 mg/kg plus infusion of 0.014 mg x kg(-1) x h(-1). Dosage C was M-6-G-bolus of 0.044 mg/kg plus infusion of 0.022 mg x kg(-1) x h(-1). Dosage D was a morphine bolus of 0.14 mg/kg plus infusion of 0.05 mg x kg(-1) x h(-1) for 4 h. Dosage E was M-6-G combined with morphine (doses A + D). Dosage F was a placebo. The analgesic effects of M-6-G and morphine were measured before administration of the bolus and after 3.5 h using an experimental pain model based on pain-related cortical potentials and pain ratings after specific stimulation of the nasal nociceptor with short pulses of gaseous carbon dioxide. Results Morphine significantly reduced subjective and objective pain correlates compared with placebo. In contrast, M-6-G produced no statistically significant effects. The addition of M-6-G to morphine did not increase the effects of morphine. Morphine produced significantly more side effects than M-6-G. Conclusion After short-term intravenous administration at doses that produce plasma concentrations of M-6-G similar to those seen after administration of morphine, M-6-G had no analgesic effects in the present placebo-controlled study in healthy volunteers.

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Review for "Corticomotor reorganization during short‐term visuomotor training in the lower back: A randomized controlled study"

10.1002/brb3.1702/v1/review1 ◽

2020 ◽

Keyword(s):

Randomized Controlled Study ◽

Controlled Study ◽

Short Term ◽

Randomized Controlled ◽

Lower Back

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Analysis of acute naproxen administration on memory in young adults: A randomized, double-blind, placebo-controlled study

Journal of Psychopharmacology ◽

10.1177/0269881117724406 ◽

2017 ◽

Vol 31 (10) ◽

pp. 1374-1376

Author(s):

Jack H Wilson ◽

Amy H Criss ◽

Sean A Spangler ◽

Katherine Walukevich ◽

Sandra Hewett

Keyword(s):

Young Adults ◽

Healthy Adult ◽

Adult Population ◽

Critical Role ◽

Random Order ◽

Controlled Study ◽

High Dose ◽

Short Term ◽

Double Blind ◽

Inflammatory Drugs

Nonsteroidal anti-inflammatory drugs work by non-selectively inhibiting cyclooxygenase enzymes. Evidence indicates that metabolites of the cyclooxygenase pathway play a critical role in the process of learning and memory. We evaluated whether acute naproxen treatment impairs short-term working memory, episodic memory, or semantic memory in a young, healthy adult population. Participants received a single dose of placebo or naproxen (750 mg) in random order separated by 7–10 days. Two hours following administration, participants completed five memory tasks. The administration of acute high-dose naproxen had no effect on memory in healthy young adults.

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Impact of nerve stimulator-guided obturator nerve block on the short-term outcomes and complications of transurethral resection of bladder tumour: A prospective randomized controlled study

Canadian Urological Association Journal ◽

10.5489/cuaj.3149 ◽

2015 ◽

Vol 9 (11-12) ◽

pp. 780 ◽

Cited By ~ 10

Author(s):

Deniz Bolat ◽

Ozgu Aydogdu ◽

Zeki Tuncel Tekgul ◽

Salih Polat ◽

Tarik Yonguc ◽

...

Keyword(s):

Spinal Anesthesia ◽

Bladder Wall ◽

Lateral Wall ◽

Adductor Muscle ◽

Obturator Nerve ◽

Controlled Study ◽

Nerve Stimulator ◽

Short Term ◽

Randomized Controlled ◽

Obturator Nerve Block

Introduction: In this prospective randomized controlled study, we investigated the efficacy of obturator nerve block (ONB) on adductor muscle spasm and related short-term outcomes and complications in patients who underwent transurethral resection of lateral wall-located bladder tumours (TURBT).Methods: Between July 2014 and February 2015, 70 patients scheduled to undergo TUR of lateral bladder wall tumours were enrolled in the study. All patients were preoperatively evaluated by cystoscopy and imaging tools and selected according to localized tumours on the lateral bladder wall. Patients were randomly allocated to Group SA (35 patients who underwent only spinal anesthesia) and Group ONB (35 patients who underwent spinal anesthesia combined with ONB by the nerve stimulator). An independent observer, blinded to the approach, evaluated the obturator signs, including adductor muscle contraction, bladder perforation, and completeness of the resection during the TURBT procedure.Results: The differences between groups regarding mean operation time, tumour size, and number were not statistically significant (p > 0.05). Adductor muscle contraction was detected in 40% of patients in Group SA and 11.4% in Group ONB. This difference was statistically significant (p = 0.021). Complete bladder perforation was detected in 2 patients in Group SA, whereas no perforation was observed in Group ONB. There was no case of severe bleeding in both groups. Conclusions: We found that ONB performed after spinal anesthesia was effective in preventing intraoperative complications due to adductor muscle spasm while performing TURBT. Our study limitations include its small sample size, since we only enrolled patients with primary lateral wall-localized bladder tumo

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Short-term effects of estrogen, tamoxifen and raloxifene on hemostasis: a randomized-controlled study and review of the literature

Thrombosis Research ◽

10.1016/j.thromres.2004.09.014 ◽

2005 ◽

Vol 116 (1) ◽

pp. 1-13 ◽

Cited By ~ 51

Author(s):

F. Cosman ◽

M. Baz-Hecht ◽

M. Cushman ◽

M.D. Vardy ◽

J.D. Cruz ◽

...

Keyword(s):

Randomized Controlled Study ◽

Controlled Study ◽

Review Of The Literature ◽

Short Term ◽

Randomized Controlled ◽

Short Term Effects

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Vitamin D3 as adjunctive therapy in the treatment of depression in tuberculosis patients: a short-term pilot randomized double-blind controlled study

Neuropsychiatric Disease and Treatment ◽

10.2147/ndt.s183039 ◽

2018 ◽

Vol Volume 14 ◽

pp. 3103-3109 ◽

Cited By ~ 2

Author(s):

Li Zhang ◽

Shanshan Wang ◽

Yuyin Zhu ◽

Tianchi Yang

Keyword(s):

Vitamin D3 ◽

Adjunctive Therapy ◽

Controlled Study ◽

Short Term ◽

Double Blind ◽

Tuberculosis Patients ◽

Treatment Of Depression

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Exposure to odours improves olfactory function in healthy children

Rhinology Journal ◽

10.4193/rhino14.192 ◽

2015 ◽

Vol 53 (3) ◽

pp. 221-226

Author(s):

E. Mori ◽

W. Petters ◽

V.A. Schriever ◽

C. Valder ◽

T. Hummel

Keyword(s):

Training Group ◽

Olfactory Function ◽

Controlled Study ◽

Healthy Children ◽

Olfactory Sensitivity ◽

Short Term ◽

Short Term Exposure ◽

Olfactory Testing ◽

Test Kit ◽

Olfactory Training

Background: Short-term exposure to odours, also called "olfactory training" has been shown to improve olfactory function in healthy people but also in people with olfactory loss. Aim of this single center, prospective, controlled study was to investigate the change of olfactory function following twice-daily, short-term exposure to 4 odours over a period of approximately 12 weeks. Material and methods: We compared odour identification abilities and odour thresholds between an olfactory training group (TR group) and a group that did not perform such training (noTR group). Participants exposed themselves twice daily to 4 odours ("rose", "eucalyptus", "lemon", "clove"). Olfactory testing was performed before and after the training period using the "Sniffin' Sticks" test kit (odour identification plus odour thresholds). Results: At baseline the two groups were not significantly different in terms of age and measures of olfactory sensitivity. The TR group performed significantly better for odour thresholds for all 4 odours compared to the noTR group after 12 weeks of olfactory training. Also, with regard to odour identification the TR group outperformed the noTR group. No significant differences were found for diary-based intensity ratings. Conclusion: Repeated exposure to odours seems to improve general olfactory sensitivity in children.

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