Surgical Margins in Lumpectomy for Breast Cancer

2012 ◽  
Vol 367 (13) ◽  
pp. 1269-1270 ◽  
Keyword(s):  
Breast Cancer ◽  
Surgical Margins

scholarly journals Advantages of Transoperative Cytology of Surgical Margins in Breast Cancer Conservative Surgery

2020 ◽  
Vol 2 (3) ◽  
pp. 01-02
Author(s):  
Juana Pérez
Keyword(s):  
Breast Cancer ◽  
Conservative Surgery ◽  
Surgical Margins ◽  
Aesthetic Result ◽  
Selection Of Patients ◽  
Freeze Biopsy ◽  
Selection Of ◽  
Multiple Causes

Today, the success of conservative surgery in breast cancer depends not only on an appropriate selection of patients, but also on the combination of adequate surgical margins with an acceptable aesthetic result. Multiple causes, can influence the probability that these borders are affected by tumor, so in this work cytology of the section margins was performed at the time of the freeze biopsy, achieving as a fundamental purpose of the study, to guarantee the advantages of cytology Transoperative, as a safe tool in breast cancer conservative surgery, among other possibilities, which in the last decade have enabled, the decrease in reinterventions caused by this cause and improve the survival of patients.

scholarly journals Can a subgroup at high risk for LRR be identified from T1-2 breast cancer with negative lymph nodes after mastectomy? A meta-analysis

2019 ◽  
Vol 39 (9) ◽  
Author(s):  
Gongling Peng ◽  
Zhuohui Zhou ◽  
Ming Jiang ◽  
Fan Yang
Keyword(s):  
Breast Cancer ◽  
High Risk ◽  
Lymph Nodes ◽  
Patient Population ◽  
Meta Analysis ◽  
Histologic Grade ◽  
Surgical Margins ◽  
Cochrane Library ◽  
Increased Risk ◽  
Negative Lymph Nodes

Abstract Purpose: To identify a subgroup at high risk for loco-regional recurrence (LRR) from T1-2 breast cancer with negative lymph nodes (N0) after mastectomy by using a meta-analysis. Methods and materials: Published studies on the relationship between clinical features and LRR of breast cancer were identified from public databases, including PubMed, EMBASE, and the Cochrane Library. High-risk features for LRR in this patient population were defined based on the pooled results of meta-analysis. Results: For the meta-analysis, a total of 11244 breast cancers with pT1-2N0 after mastectomy from 20 publications were included for analysis. The pooled results indicated that age (hazard ratio (HR) 1.77, P=0.001), lymphovascular invasion (LVI) (HR 2.23, P<0.001), histologic grade (HR 1.66, P<0.001), HER2 status (HR 1.65, P=0.027), menopausal status (HR 1.36, P=0.015), and surgical margins (HR 2.56, P=0.014) were associated with a significantly increased risk of developing LRR in this patient population group, but not for tumor size (HR 1.32, P=0.23), systematic therapy (HR 1.67, P=0.20), and hormonal receptor status (HR 1.04, P=0.73). Conclusion: In the current study, patients with young age, positive LVI, high histologic grade, HER-2 positive, premenopausal, and positive surgical margins have an increased risk of developing LRR. Further prospective trials are needed to clearly define the role of adjuvant postmastectomy radiotherapy in T1-2N0 breast cancer at high risk of developing LRR.

Intraoperative ICG-fluorescence imaging for surgical margins evaluation in breast cancer

The Breast ◽  
2019 ◽  
Vol 44 ◽  
pp. S119
Author(s):  
C.F. Pop ◽  
D. Noterman ◽  
F. De Neubourg ◽  
R. Barbieux ◽  
M. Chintinne ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fluorescence Imaging ◽  
Surgical Margins

Complete Excision of Primary Breast Tumor Improves Survival of Patients With Metastatic Breast Cancer at Diagnosis

2006 ◽  
Vol 24 (18) ◽  
pp. 2743-2749 ◽  
Author(s):  
Elisabetta Rapiti ◽  
Helena M. Verkooijen ◽  
Georges Vlastos ◽  
Gerald Fioretta ◽  
Isabelle Neyroud-Caspar ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Primary Tumor ◽  
Breast Tumor ◽  
Metastatic Breast ◽  
Surgical Margins ◽  
Primary Breast Tumor ◽  
Complete Excision ◽  
Risk Of Death ◽  
The Impact

Purpose Surgery of the primary tumor usually is not advised for patients with metastatic breast cancer at diagnosis because the disease is considered incurable. In this population-based study, we evaluate the impact of local surgery on survival of patients with metastatic breast cancer at diagnosis. Methods We included all 300 metastatic breast cancer patients recorded at the Geneva Cancer Registry between 1977 and 1996. We compared mortality risks from breast cancer between patients who had surgery of the primary breast tumor to those who had not and adjusted these risks for other prognostic factors. Results Women who had complete excision of the primary breast tumor with negative surgical margins had a 40% reduced risk of death as a result of breast cancer (multiadjusted hazard ratio [HR], 0.6; 95% CI, 0.4 to 1.0) compared with women who did not have surgery (P = .049). This mortality reduction was not significantly different among patients with different sites of metastasis, but in the stratified analysis the effect was particularly evident for women with bone metastasis only (HR, 0.2; 95% CI, 0.1 to 0.4; P = .001). Survival of women who had surgery with positive surgical margins was not different from that of women who did not have surgery. Conclusion Complete surgical excision of the primary tumor improves survival of patients with metastatic breast cancer at diagnosis, particularly among women with only bone metastases.

Optimizing Clinical Management of Surgical Margins in Breast-Conserving Therapy for Breast Cancer

2013 ◽  
pp. 66-71
Author(s):  
Stephen R. Grobmyer ◽  
Michael S. Cowher ◽  
Joseph P. Crowe
Keyword(s):  
Breast Cancer ◽  
Retrospective Studies ◽  
Tumor Biology ◽  
Surgical Margin ◽  
Breast Conserving Therapy ◽  
Surgical Margins ◽  
Margin Assessment ◽  
Margin Width ◽  
Definition Of ◽  
Made In

There has been, and continues to be, significant controversy over the definition of an “optimal” surgical margin in breast-conserving therapy (BCT). The historic basis of this controversy stems from the original trials documenting the safety of BCT and many conflicting retrospective studies that have sought to define the association between surgical margin width and outcomes over the last 20 years. It is important to understand that margin assessment is an inexact science, and current laboratory approaches to surgical-margin assessment represent only a sampling of the surgical margin. Currently available evidence suggests that decisions regarding surgical margins in BCT should be made in the context of what is known about the biology of breast cancer, as well the interactions of tumor biology, adjuvant treatment for breast cancer, and outcomes. Achieving consensus on management of surgical margins in BCT should be a clinical priority as it offers the opportunity to reduce the burden of breast cancer treatment on patients without compromising cancer-related outcomes.

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