The role of plasmalogens, Forssman lipids, and sphingolipid hydroxylation in modulating the biophysical properties of the epithelial plasma membrane

2021 ◽  
Vol 154 (9) ◽  
pp. 095101
Author(s):  
Katie A. Wilson ◽  
Stephen J. Fairweather ◽  
Hugo I. MacDermott-Opeskin ◽  
Lily Wang ◽  
Richard A. Morris ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Biophysical Properties

Role of Exosomes in the Exchange of Spermatozoa after Leaving the Seminiferous Tubule: A Review

2020 ◽  
Vol 21 (5) ◽  
pp. 330-338
Author(s):  
Luming Wu ◽  
Yuan Ding ◽  
Shiqiang Han ◽  
Yiqing Wang
Keyword(s):  
Drug Delivery ◽  
Plasma Membrane ◽  
Seminiferous Tubule ◽  
Metabolic Diseases ◽  
Inflammatory Diseases ◽  
Multivesicular Bodies ◽  
Extensive Search ◽  
Neurological Research ◽  
The One

Background: Exosomes are extracellular vesicles (EVs) released from cells upon fusion of an intermediate endocytic compartment with the plasma membrane. They refer to the intraluminal vesicles released from the fusion of multivesicular bodies with the plasma membrane. The contents and number of exosomes are related to diseases such as metabolic diseases, cancer and inflammatory diseases. Exosomes have been used in neurological research as a drug delivery tool and also as biomarkers for diseases. Recently, exosomes were observed in the seminal plasma of the one who is asthenozoospermia, which can affect sperm motility and capacitation. Objective: The main objective of this review is to deeply discuss the role of exosomes in spermatozoa after leaving the seminiferous tubule. Methods: We conducted an extensive search of the literature available on relationships between exosomes and exosomes in spermatozoa on the bibliographic database. Conclusion: : This review thoroughly discussed the role that exosomes play in the exchange of spermatozoa after leaving the seminiferous tubule and its potential as a drug delivery tool and biomarkers for diseases as well.

scholarly journals Role of the plasma membrane in cholesterol esterification in rat hepatoma cells

1993 ◽  
Vol 268 (19) ◽  
pp. 13838-13843 ◽  
Author(s):  
Y. Lange ◽  
F. Strebel ◽  
T.L. Steck
Keyword(s):  
Plasma Membrane ◽  
Hepatoma Cells ◽  
Cholesterol Esterification ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

scholarly journals Role of G protein beta gamma subunits in the regulation of the plasma membrane Ca2+ pump.

1992 ◽  
Vol 267 (4) ◽  
pp. 2375-2379 ◽  
Author(s):  
S Lotersztajn ◽  
C Pavoine ◽  
P Deterre ◽  
J Capeau ◽  
A Mallat ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
G Protein ◽  
Gamma Subunits

Conformational Changes of Yeast Plasma Membrane H+-ATPase during Activation by Glucose:  Role of Threonine-912 in the Carboxy-Terminal Tail†

Biochemistry ◽  
2005 ◽  
Vol 44 (50) ◽  
pp. 16624-16632 ◽  
Author(s):  
Silvia Lecchi ◽  
Kenneth E. Allen ◽  
Juan Pablo Pardo ◽  
A. Brett Mason ◽  
Carolyn W. Slayman
Keyword(s):  
Plasma Membrane ◽  
Conformational Changes ◽  
Yeast Plasma Membrane ◽  
Carboxy Terminal

scholarly journals Functional Role of Charged Residues in the Transmembrane Segments of the Yeast Plasma Membrane H+-ATPase

2000 ◽  
Vol 275 (21) ◽  
pp. 15709-15716 ◽  
Author(s):  
Valery V. Petrov ◽  
Kristine P. Padmanabha ◽  
Robert K. Nakamoto ◽  
Kenneth E. Allen ◽  
Carolyn W. Slayman
Keyword(s):  
Plasma Membrane ◽  
Functional Role ◽  
Yeast Plasma Membrane ◽  
Transmembrane Segments ◽  
Charged Residues

Role of caveolae in the pathogenesis of cholesterol-induced gallbladder muscle hypomotility

2007 ◽  
Vol 292 (6) ◽  
pp. G1641-G1649 ◽  
Author(s):  
Zuoliang Xiao ◽  
Frank Schmitz ◽  
Victor E. Pricolo ◽  
Piero Biancani ◽  
Jose Behar
Keyword(s):  
Plasma Membrane ◽  
Muscle Contraction ◽  
Muscle Cells ◽  
Protein Fragment ◽  
Total Binding

Muscle cells from human gallbladders (GB) with cholesterol stones (ChS) exhibit a defective contraction, excess cholesterol (Ch) in the plasma membrane, and lower binding of CCK-1 receptors. These abnormalities improved after muscle cells were incubated with Ch-free liposomes that remove the excess Ch from the plasma membrane. The present studies were designed to investigate the role of caveolin-3 proteins (Cav-3) in the pathogenesis of these abnormalities. Muscle cells from GB with ChS exhibit higher Ch levels in the plasma membrane that were mostly localized in caveolae and associated with parallel increases in the expression of Cav-3 in the caveolae compared with that in GB with pigment stones (PS). The overall number of CCK-1 receptors in the plasma membrane was not different between muscle cells from GB with ChS and PS, but they were increased in the caveolae in muscle cells from GB with ChS. Treatment of muscle cells from GB with ChS with a Gαi3 protein fragment increased the total binding of CCK-1 receptors (from 8.3 to 11.2%) and muscle contraction induced by CCK-8 (from 11.2 to 17.3% shortening). However, Gαq/11 protein fragment had no such effect. Moreover, neither fragment had any effect on muscle cells from GB with PS. We conclude that the defective contraction of muscle cells with excessive Ch levels in the plasma membrane is due to an increased expression of Cav-3 that results in the sequestration of CCK-1 receptors in the caveolae, probably by inhibiting the functions of Gαi3 proteins.

Dual role of K+ and Na+ on the transport of [3H]-γ-aminobutyric acid by synaptic plasma membrane vesicles

1995 ◽  
Vol 32 (1) ◽  
pp. 161-165 ◽  
Author(s):  
Paula P. Gonçalves ◽  
Arselio P. Carvalho
Keyword(s):  
Plasma Membrane ◽  
Membrane Vesicles ◽  
Dual Role ◽  
Aminobutyric Acid ◽  
Synaptic Plasma Membrane ◽  
Plasma Membrane Vesicles

scholarly journals Role of Ca2+ in pyruvate dehydrogenase interconversion in brain mitochondria and synaptosomes

1985 ◽  
Vol 227 (1) ◽  
pp. 129-136 ◽  
Author(s):  
R G Hansford ◽  
F Castro
Keyword(s):  
Plasma Membrane ◽  
Steady State ◽  
Pyruvate Dehydrogenase ◽  
Maximal Activity ◽  
Brain Mitochondria ◽  
Ruthenium Red ◽  
Ion Concentration ◽  
Maximal Effect ◽  
State Content

The steady-state content of active (dephospho) pyruvate dehydrogenase (PDHA) of suspensions of coupled rat brain mitochondria oxidizing succinate was found to be markedly increased with increasing free Ca2+ ion concentration of the medium, with a half-maximal effect at 10(-6.43) M Ca2+. Other ions were present in these studies at concentrations appropriate for the cytosol. Depolarization of the plasma membrane of synaptosomes caused an increase in the steady-state content of PDHA, with veratridine giving a larger increase than depolarization by 33 mM-KCl. Values were 68 +/- 1% (n = 13) and 81 +/- 1% (n = 19) of maximal activity, for control incubations and incubations in the presence of 30 microM-veratridine, respectively. Measurements of cytosolic free Ca2+ concentrations ([Ca2+]cyt.) in these suspensions of synaptosomes, with the use of the fluorescent Ca2+-indicator Quin-2, indicated an increase on depolarization, with the change due to 30 microM-veratridine being larger in extent than that due to 33 mM-KCl. Values were 217 +/- 21 nM (n = 15), 544 +/- 48 nM (n = 15) and 783 +/- 75 nM (n = 14) for control, KCl-depolarized and veratridine-depolarized synaptosomes respectively. Experiments in which synaptosomes were treated with Ruthenium Red, an inhibitor of mitochondrial Ca2+ uptake, gave much lower resting contents of PDHA (42 +/- 2% of maximal), but failed to prevent totally an increase on depolarization. Addition of an excess of EGTA to the synaptosomal suspension just before the addition of veratridine resulted in a partial diminution in the response of PDHA content. Parallel studies with Quin-2 indicated no increase in [Ca2+]cyt. on addition of veratridine, under these conditions. Thus an increase in [Ca2+]cyt. forms only a part of the mechanism whereby pyruvate dehydrogenase interconversion responds to depolarization. A decrease in the ATP/ADP ratio may also be important, as inferred from the results of experiments with ouabain, which inhibits the Na+ + K+-dependent ATPase.

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