Rheology and morphology of Pluronic F68 in water

2021 ◽  
Vol 33 (4) ◽  
pp. 043113
Author(s):  
Salvatore Costanzo ◽  
Alfonso Di Sarno ◽  
Marina D'Apuzzo ◽  
Pietro Renato Avallone ◽  
Ernesto Raccone ◽  
...  
Keyword(s):  
Pluronic F68

Influence of pluronic F68 on oxygen mass transfer

2013 ◽  
Vol 29 (5) ◽  
pp. 1278-1288 ◽  
Author(s):  
Christian Sieblist ◽  
Marco Jenzsch ◽  
Michael Pohlscheidt
Keyword(s):  
Mass Transfer ◽  
Oxygen Mass Transfer ◽  
Pluronic F68

NANOEMULSIONS BASED ON LIPOIC ACID DERIVATIVES WITH VARIOUS ALCOHOLS: PRODUCTION AND INFLUENCE ON FUNCTIONAL ACTIVITY OF PLATELETS

2020 ◽  
pp. 461-464
Author(s):  
A. Sinebryukhova ◽  
A. Shipelova ◽  
E. Darnotuk ◽  
A. Chekanov ◽  
O. Baranova ◽  
...  
Keyword(s):  
Particle Size ◽  
Arachidonic Acid ◽  
Lipoic Acid ◽  
Encapsulation Efficiency ◽  
Room Temperature ◽  
Optimal Conditions ◽  
Pluronic F68 ◽  
Long Term Storage ◽  
Term Storage

The optimal conditions were selected for obtaining homogeneous nanoemulsions (NE) of lipoic acid conjugates (LA-conjugates) based on Pluronic F68 (1,8%) with a particle size not exceeding 400 nm, characterized by 97±2% encapsulation efficiency of substances in nanoparticles (NP). A heterogeneous NE (polydispersity index, PDI>0,3) with the derivative of LA and myo-inositol based on phosphatidylcholine (PC, C = 3 mg/ml) was also obtained consisting of 2 particle fractions: 20–70 nm (27%) and 122–212 nm (73%). The obtained NEs with LA-conjugates based on Pluronic F68 and PC were stable during long-term storage (more than 12 months) at room temperature. The effect of the obtained NEs of LA-conjugates on platelet aggregation (Pt) caused by arachidonic acid (AA) was determined, and a mechanism of their action was proposed.

scholarly journals Effect of Hyaluronic Acid and Pluronic-F68 on the Surface Properties of Foam as a Delivery System for Polidocanol in Sclerotherapy

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1039
Author(s):  
Teresa del Castillo-Santaella ◽  
Yan Yang ◽  
Inmaculada Martínez-González ◽  
María José Gálvez-Ruiz ◽  
Miguel Ángel Cabrerizo-Vílchez ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Delivery System ◽  
Surface Characterization ◽  
Positive Impact ◽  
Foam Stability ◽  
Surface Elasticity ◽  
Foam Sclerotherapy ◽  
Pluronic F68 ◽  
Surface Active ◽  
Bioactive Agents

The use of foams to deliver bioactive agents and drugs is increasing in pharmaceutics. One example is the use of foam as a delivery system for polidocanol (POL) in sclerotherapy, with the addition of bioactive compounds to improve the delivery system being a current subject of study. This work shows the influence of two bioactive additives on the structure and stability of POL foam: hyaluronic acid (HA) and Pluronic-F68 (F68). HA is a natural non-surface-active biopolymer present in the extracellular matrix while F68 is a surface-active poloxamer that is biocompatible with plasma-derived fluids. Both additives increase the bulk viscosity of the sample, improving foam stability. However, HA doubled and F68 quadruplicated the foam half lifetime of POL. HA reduced the size and polydispersity of the bubble size distribution and increased the surface elasticity with respect to POL. Both facts have a positive impact in terms of foam stability. F68 also altered bubble structure and increased surface elasticity, again contributing to the enhancement of foam stability. The surface characterization of these systems is important, as in foam sclerotherapy it is crucial to assure the presence of POL at the surface of the bubbles in order to deliver the sclerosant agent in the target vein.

Harmine-loaded galactosylated pluronic F68-gelucire 44/14 mixed micelles for liver targeting

2019 ◽  
Vol 45 (8) ◽  
pp. 1361-1368 ◽  
Author(s):  
Jeetendra Prasad Kushwaha ◽  
Debjani Baidya ◽  
Sharvil Patil
Keyword(s):  
Mixed Micelles ◽  
Pluronic F68 ◽  
Liver Targeting

scholarly journals Control of the properties of porous chitosan–alginate membranes through the addition of different proportions of Pluronic F68

2014 ◽  
Vol 44 ◽  
pp. 117-125 ◽  
Author(s):  
Cecilia Zorzi Bueno ◽  
Ana Maria Antunes Dias ◽  
Hermínio José Cipriano de Sousa ◽  
Mara Elga Medeiros Braga ◽  
Ângela Maria Moraes
Keyword(s):  
Pluronic F68 ◽  
Porous Chitosan

Effect of pluronic F68 block copolymer on P-glycoprotein transport and CYP3A4 metabolism

2008 ◽  
Vol 356 (1-2) ◽  
pp. 351-353 ◽  
Author(s):  
Jiangeng Huang ◽  
Luqin Si ◽  
Lingli Jiang ◽  
Zhaoze Fan ◽  
Jun Qiu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Pluronic F68 ◽  
P Glycoprotein ◽  
Glycoprotein Transport

Colloidal stability of Pluronic F68-coated PLGA nanoparticles: A variety of stabilisation mechanisms

2006 ◽  
Vol 302 (2) ◽  
pp. 522-529 ◽  
Author(s):  
M.J. Santander-Ortega ◽  
A.B. Jódar-Reyes ◽  
N. Csaba ◽  
D. Bastos-González ◽  
J.L. Ortega-Vinuesa
Keyword(s):  
Colloidal Stability ◽  
Plga Nanoparticles ◽  
Pluronic F68
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