Emulsion formulation of curcumin in soybean oil with a combination surfactant of Tween-80 and lecithin using wet ball milling method

2021 ◽  
Author(s):  
Miftakhul Jannah ◽  
Maria Lucia Ardhani Dwi Lestari ◽  
Ellya Indah Yanti ◽  
Zubaidah Ningsih
Author(s):  
Shobbu Ibabas Sholihat ◽  
Ellya Indahyanti ◽  
Maria Lucia A.D Lestari ◽  
Zubaidah Ningsih

Ionics ◽  
2019 ◽  
Vol 25 (11) ◽  
pp. 5565-5573
Author(s):  
Qing Zhao ◽  
Xuetian Li ◽  
Zhongbao Shao ◽  
Chengjun Liu ◽  
Ron Zevenhoven

2021 ◽  
Vol 1 (1) ◽  
pp. 16
Author(s):  
Zubaidah Ningsih ◽  
Maria Lucia A.D Lestari ◽  
Salza Aprilia Rahma Maharin

Nanoemulsion has been developed as a drug delivery system which increases bioavailability and effectiveness of curcumin. Many methods and formulations have been applied in order to fabricate the most efficient nanoemulsion system to deliver curcumin. Wet ball milling is a simple technique to grind solids like powder to produce nano emulsion. On the other hand, a combination of olive oil and curcumin in Mediterranian Diet shows a promising anticancer activity. This research aims to elaborate the preparation and characterization of curcumin nanoemulsion in olive oil-Tween 80 system with wet ball milling method. It is expected that the procedure yields a combination of curcumin and olive oil in nanoemulsion system with simple preparation. This research uses curcumin as active compound, olive oil as solvent for curcumin, Tween 80 as stabilizer, and water as dispersing agent. Particle size and polydispersity index are determined using Dynamic Light Scattering technique. The results show that the best milling time is 8 hours to produce nanoemulsion that has diameter of 303 nm and polidispersity index of 0.29. Nanoemulsion system is stable for 60 days storage at 4 oC and 25 oC. The maximum curcumin mass that can be loaded in the system while maintaining particle size in nanoemulsion range is 300 mg.


2021 ◽  
Author(s):  
Huijuan Shao ◽  
Peng Yao ◽  
Yi Chen ◽  
Yue Yao ◽  
Guangbi Li ◽  
...  

α-Fe2O3/g-C3N4, is attributed to a Z-scheme structure, and with excellent photocatalytic ability. But this composites were prepared by conventional, the calcination/hydrothermal method. Above two methods are time-consuming and high cost...


2017 ◽  
Vol 5 (6) ◽  
pp. 5599-5607 ◽  
Author(s):  
Carla A. Orge ◽  
O. Salomé G.P. Soares ◽  
Joaquim L. Faria ◽  
M. Fernando R. Pereira

2017 ◽  
Vol 4 (2) ◽  
pp. 68 ◽  
Author(s):  
Anita Ratna Faoziyah ◽  
Wahyu Kurniawan

This research was done to study mangrove leaves (Rhizophora mucronata sp.) utilization in the Cilacap regency brackish waters. The research goal is to make nano emulsion from mangrove plants as an alternative to increase the economic value of mangrove. This research method has 2 phases. In the first phase, mangrove leaves was extracted using various solvent. In the second phase mangrove leaves extract was formulated as nano emulsion as anti-cancer treatment along as an alternative to increase mangrove leaves economic value. Extraction results of mangrove leaves using various solvent such as hexane, ethyl acetate and ethanol show that using ethanol p.a solvent with the young leaves of mangrove giving the highest amount extract as much as 18.24%. Mangrove leaves extract nano emulsion can be prepared using Self-Nano Emulsifying Drug Delivery System (SNEDDS) technique. The SNEDDS technique nano emulsion formulation started with 14 formulas. The best formula from this study was using Tween 80 : PEG 400 : Fish Oil as much as 6 ml: 1 ml: 1 ml dosage ratio. Using the best formula, it was added with 5 mg of mangrove leaves extract. The result test of Drug Loading, calculation of Emulsification Time and Dissolution test show that mangrove leaves extract has the potential to be used as an active substance anti-cancer on nano emulsion manufacturing.


2011 ◽  
Vol 311-313 ◽  
pp. 1281-1285 ◽  
Author(s):  
Pei Hao Lin ◽  
Lei Wang ◽  
Shun Kang Pan ◽  
Hua Mei Wan

The NdFe magnetic absorbing materials were prepared by rapid solidification and high-energy ball milling method. The effect of high-energy ball milling on particle morphology, organizational structure and microwave absorbing properties of NdFe magnetic absorbing materials were analyzed with the aid of X-ray diffractometer, scanning electron microscope and vector network analysis. The results show that the Nd2Fe17 and α-Fe phase are refined, the particles become smaller and thinner; the span-ratio of the particles increases along with time during the process of high-energy ball milling; and meanwhile, the frequency of absorbing peak reduces. The absorbing bandwidth broadens as the increase of the time of ball milling, except that of 48h.The minimum reflectance of the powder decreases from -22dB to - 44dB under the circumstances that the time of high energy ball milling reaches 48h and the thickness of the microwave absorbing coating is 1.5mm. But it rebounds to about - 6dB when the time of ball milling reaches 72h.


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