Potential of X. testudinaria sponge from the waters of the Spermonde Islands, Indonesia as a dengue viral inhibitor drug (dengue antiviral)

2021 ◽  
Author(s):  
Nur Awaliah ◽  
Nunuk Hariani Soekamto ◽  
Firdaus ◽  
Felycitae Ekalaya Appa ◽  
Septaria Yolan Kalalinggi
Keyword(s):  
Viral Inhibitor ◽  
Inhibitor Drug

New COX-2 Inhibitor Drug Called Nonapprovable by FDA

2007 ◽  
Vol 35 (5) ◽  
pp. 46
Author(s):  
ALICIA AULT
Keyword(s):  
Cox 2 ◽  
Inhibitor Drug

Encapsulation of Imatinib in Targeted KIT-5 Nanoparticles for Reducing its Cardiotoxicity and Hepatotoxicity

2020 ◽  
Vol 20 (16) ◽  
pp. 1966-1980
Author(s):  
Jaleh Varshosaz ◽  
Saeedeh Fardshouraki ◽  
Mina Mirian ◽  
Leila Safaeian ◽  
Setareh Jandaghian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Side Effects ◽  
Kinase Inhibitor ◽  
Lymphoblastic Leukemia ◽  
Drug Carrier ◽  
Free Drug ◽  
Jurkat Cells ◽  
Targeted Nanoparticles ◽  
Inhibitor Drug ◽  
Histopathological Results

Background: Using imatinib, a tyrosine kinase inhibitor drug used in lymphoblastic leukemia, has always had limitations due to its cardiotoxicity and hepatotoxicity side effects. The objective of this study is to develop a target-oriented drug carrier to minimize these adverse effects by the controlled release of the drug. Methods: KIT-5 nanoparticles were functionalized with 3-aminopropyltriethoxysilane and conjugated to rituximab as the targeting agent for the CD20 positive receptors of the B-cells. Then they were loaded with imatinib and their physical properties were characterized. The cell cytotoxicity of the nanoparticles was studied by MTT assay in Ramos (CD20 positive) and Jurkat cell lines (CD20 negative) and their cellular uptake was shown by fluorescence microscope. Wistar rats received an intraperitoneal injection of 50 mg/kg of the free drug or targeted nanoparticles for 21 days. Then the level of aspartate Aminotransferase (AST), alanine Aminotransferase (ALT), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH) were measured in serum of animals. The cardiotoxicity and hepatotoxicity of the drug were also studied by hematoxylin and eosin staining of the tissues. Results: The targeted nanoparticles of imatinib showed to be more cytotoxic to Ramos cells rather than Jurkat cells. The results of the biochemical analysis displayed a significant reduction in AST, ALT, ALP, and LDH levels in animals treated with targeted nanoparticles, compared to the free drug group. By comparison with the free imatinib, histopathological results represented less cardiotoxicity and hepatotoxicity in the animals, which received the drug through the current designed delivery system. Conclusion: The obtained results confirmed that the rituximab targeted KIT-5 nanoparticles are promising in the controlled release of imatinib and could decrease its cardiotoxicity and hepatotoxicity side effects.

scholarly journals Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4358
Author(s):  
Sherif A. Abdel-Gawad ◽  
Hany H. Arab ◽  
Alhumaidi B. Alabbas
Keyword(s):  
Proton Pump ◽  
Industrial Wastewater ◽  
Mobile Phase ◽  
Solid Phase ◽  
Potassium Dihydrogen Phosphate ◽  
Ultra Performance Liquid Chromatography ◽  
Dihydrogen Phosphate ◽  
Separation Pattern ◽  
Inhibitor Drug ◽  
Wastewater Samples

Monitoring and quantification of active pharmaceutical ingredients (APIs) in the environment constitute important and challenging tasks, as they are directly associated with human health. Three commonly used proton pump inhibitors (PPIs), namely, omeprazole sodium (OMP), pantoprazole sodium (PNT), and lansoprazole sodium (LNZ) are well separated and quantified using ultra-performance liquid chromatography (UPLC) in pharmaceutical industrial wastewater. The separation of the studied drugs was performed on a stationary phase with a WatersTM column (100 × 2.1 mm, 1.7 µm). The mobile phase was composed of methanol:0.05 M potassium dihydrogen phosphate buffer (adjusted to pH 7.5 using NaOH) (50:50, v/v). The elution process was done in gradient mode by changing the relative proportions of the mobile phase components with time to get an optimum separation pattern. The flow rate of the developing system was adjusted to 0.8 mL/minute. Detection of the separated drugs was performed at 230 nm. The studied drugs were quantified in the concentration range of 10–200 ng/mL for all drugs. The cited method was fully validated according to the international conference on harmonization (ICH-Q2B) guidelines, then it was applied successfully for quantification of the studied PPIs in real wastewater samples after their solid phase extraction (SPE).

scholarly journals Passive characteristics and Arrhenius responses of expired inhibitor drug on UNG1050 steel

2021 ◽  
Vol 1107 (1) ◽  
pp. 012223
Author(s):  
S.K.U Tijani ◽  
O.A. Odulanmi ◽  
O.S.I. Fayomi ◽  
A.B. Williams ◽  
M. Daramola
Keyword(s):  
Inhibitor Drug

Rapid and Sensitive Liquid Chromatographic Method for Determination of Anastrozole in Different Polymer–Lipid Hybrid Nanoparticles

2021 ◽  
pp. 247263032098230
Author(s):  
Dilshad Ahmad ◽  
Faisal A. Al Meshaiti ◽  
Yazeed K. Al Anazi ◽  
Osama Al Owassil ◽  
Alaa Eldeen B. Yassin
Keyword(s):  
High Performance ◽  
Limit Of Detection ◽  
Reversed Phase ◽  
Hplc Method ◽  
Hybrid Nanoparticles ◽  
Array Detector ◽  
Relative Standard ◽  
Validation Parameters ◽  
Limit Of Quantitation ◽  
Inhibitor Drug

Anastrozole, an aromatase inhibitor drug, is used for the treatment of breast cancer in pre- and postmenopausal women. Anastrozole’s incorporation into nanoparticulate carriers would enhance its therapeutic performance. To perceive the exact loaded amount of drug in nanocarriers, a valid analytical method is required. The reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated by using the C18 column, 150 × 4.6 mm, 5 µm particle size, in isocratic mobile phase composed of 50:50 V/V (volume/volume) acetonitrile–phosphate buffer (pH 3) flowing at a rate of 1.0 mL/min, and a diode array detector (DAD) set at λmax = 215 nm. The validation parameters such as linearity, accuracy, specificity, precision, and robustness have proven the accuracy of the method, with the relative standard deviation percentage (% RSD) values < 2. The limit of detection of the method was found equal to 0.0150 µg/mL, and the limit of quantitation was 0.0607 µg/mL. The percent recovery of sample was in the range of 98.04–99.25%. The method has the advantage of being rapid with a drug retention time of 2.767 min, specific in terms of resolution of peaks void of interference with any of the excipients, and high reproducibility. This makes it highly applicable for quality control purposes.

Exploiting the exploiter: a viral inhibitor stabilizes TAP for cryo-EM

2016 ◽  
Vol 23 (2) ◽  
pp. 95-97 ◽  
Author(s):  
Rutger D Luteijn ◽  
Emmanuel J H J Wiertz
Keyword(s):  
Viral Inhibitor

Towards kit-like 18F-labeling of marimastat, a noncovalent inhibitor drug for in vivo PET imaging cancer associated matrix metalloproteases

MedChemComm ◽  
2011 ◽  
Vol 2 (10) ◽  
pp. 942 ◽  
Author(s):  
Ying Li ◽  
Richard Ting ◽  
Curtis W. Harwig ◽  
Ulrich auf dem Keller ◽  
Caroline L. Bellac ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Matrix Metalloproteases ◽  
Associated Matrix ◽  
Inhibitor Drug

scholarly journals HIV-1 Phenotypic Reverse Transcriptase Inhibitor Drug Resistance Test Interpretation Is Not Dependent on the Subtype of the Virus Backbone

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34708 ◽  
Author(s):  
Michelle Bronze ◽  
Kim Steegen ◽  
Carole L. Wallis ◽  
Hans De Wolf ◽  
Maria A. Papathanasopoulos ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Reverse Transcriptase ◽  
Transcriptase Inhibitor ◽  
Resistance Test ◽  
Test Interpretation ◽  
Inhibitor Drug ◽  
Reverse Transcriptase Inhibitor ◽  
Hiv 1
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