Tumor necrosis factor-α and interleukin-1 β levels in recurrent and persistent otitis media with effusion

2002 ◽  
Vol 126 (4) ◽  
pp. 417-422 ◽  
Author(s):  
Sertac Yetiser ◽  
Bulent Satar ◽  
Atilla Gumusgun ◽  
Faruk Unal ◽  
Yalcin Ozkaptan
Keyword(s):  
Tumor Necrosis Factor ◽  
Otitis Media ◽  
Tumor Necrosis ◽  
Otitis Media With Effusion ◽  
Interleukin 1 ◽  
Tertiary Referral Center ◽  
Adenoid Tissue ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

OBJECTIVE: Based on interleukin (IL)-1β and tumor necrosis factor (TNF)-α levels in effusions, our goals were to specify either recurrent or persistent otitis media with effusion (OME) is a mid stage in the development of chronic disease and to identify the factors that have an influence on cytokine levels. STUDY DESIGN: Samples from groups with recurrent (n = 15) and persistent (n = 39) OME were essayed for IL-1 β and TNF-α. Children were also grouped with respect to age, sex, quality of effusion, and the presence of pharyngeal adenoid tissue. SETTING: Tertiary referral center. RESULTS: In recurrent and persistent OME groups, IL-1β was higher than TNF-α ( P < 0.01). IL-β was higher in recurrent OME than in persistent OME ( P < 0.05). CONCLUSION: Recurrent OME seems to be closer to the chronic stage of the disease relative to persistent OME in terms of higher IL-1 β levels. Each exacerbation of acute disease in recurrent otitis media is likely to be mediated by IL-1 β. SIGNIFICANCE: We were able to clarify that recurrent OME is a stage that occurs before chronic OME. Therefore, the prevention of acute attacks in recurrent disease would also impede long-term damage to the middle ear.

Differential Effects of Interleukin 1-α (IL-1α) or Tumor Necrosis Factor-α (TNF-α) on Motility of Human Melanoma Cell Lines on Fibronectin

1994 ◽  
Vol 102 (6) ◽  
pp. 898-905 ◽  
Author(s):  
Sybren K Dekker ◽  
Jacqueline Vink ◽  
Bert Jan Vermeer ◽  
Jan A Bruijn ◽  
Martin C Mihm ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Cell Lines ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1 ◽  
Human Melanoma ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor ◽  
Melanoma Cell Lines

scholarly journals Interleukin-1 stimulates tumor necrosis factor-α (TNF-α) release from cytotrophoblastic BeWo cells independently of induction of the TNF-α mRNA

FEBS Letters ◽  
1997 ◽  
Vol 405 (2) ◽  
pp. 213-218 ◽  
Author(s):  
Martin Knöfler ◽  
Herbert Kiss ◽  
Barbara Mösl ◽  
Christian Egarter ◽  
Peter Husslein
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1 ◽  
Bewo Cells ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion

2001 ◽  
Vol 110 (10) ◽  
pp. 917-921 ◽  
Author(s):  
Eun-Ju Jeun ◽  
Yong-Soo Park ◽  
Sang W. Yeo ◽  
Young-Chul Choi ◽  
Timothy T. K. Jung
Keyword(s):  
Tumor Necrosis Factor ◽  
Vascular Permeability ◽  
Otitis Media ◽  
Middle Ear ◽  
Tumor Necrosis ◽  
Otitis Media With Effusion ◽  
Combination Group ◽  
Tnf Α ◽  
Temporal Bones ◽  
Necrosis Factor

Tumor necrosis factor (TNF)-α is important in the pathogenesis of otitis media with effusion (OME). The purpose of this study was to determine the effect of TNF-α antagonist on the outcome of lipopolysaccharide (LPS)-induced OME in rats. Otitis media was induced by injecting Pseudomonas aeruginosa LPS transtympanically. Another (combination) group was pretreated with TNF-α antagonist, soluble TNF receptor type I (sTNF RI), before transtympanic injection of LPS. Saline and phosphate-buffered saline solutions were used as controls. Twelve hours after the transtympanic injection, otoscopic examination and aspiration of middle ear effusion (MEE) were done. The temporal bones in each group were examined histopathologically, and the vascular permeability of the middle ear mucosa was measured by the Evans blue vital dye technique. In the LPS and combination groups, MEE developed in 90% and 0% of ears, respectively. The combination group showed less inflammation, less mucosal thickening, and significantly decreased vascular permeability as compared to the LPS group. Transtympanic administration of sTNF RI appears to suppress the development of LPS-induced OME. This study suggests that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE.

Relationship of Endotoxin to Tumor Necrosis Factor–α and Interleukin-1β in Children with Otitis Media with Effusion

1998 ◽  
Vol 107 (1) ◽  
pp. 28-33 ◽  
Author(s):  
Darryl N. Willett ◽  
Rod P. Rezaee ◽  
John M. Billy ◽  
Mary B. Tighe ◽  
Thomas F. DeMaria
Keyword(s):  
Otitis Media ◽  
Total Protein ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Otitis Media With Effusion ◽  
Chronic Otitis Media ◽  
Tnf Α ◽  
Factor Α ◽  
Mean Concentration ◽  
Necrosis Factor

Sixty-five middle ear effusions and paired sera from 41 children with chronic otitis media with effusion were assayed for endotoxin and for tumor necrosis factor–α (TNF-α) and interleukin-1β (IL-1β) in order to establish whether a correlation exists between the concentrations of endotoxin and of these cytokines. Endotoxin concentration was determined by means of a chromogenic limulus amebocyte lysate assay, and the cytokine concentration by means of a quantitative enzyme-linked immunosorbent assay. Forty percent of the effusions had detectable levels of endotoxin, with a mean concentration of 2.9 ± 7.8 endotoxin units per milligram of total protein. The mean concentration of TNF-α was 1.24 ± 3.1 pg/mg total protein, and that of IL-1β was 18.79 pg/mg total protein. A strong, statistically significant correlation exists between the concentrations of endotoxin and TNF-α (r =.89) and IL-1β (r =.72). The data indicate that endotoxin may contribute to the pathogenesis of chronic otitis media with effusion by stimulating the sustained production of TNF-α and IL-1β in the middle ear.

Determining Serum Haptoglobin and Proinflammatory Cytokines Concentration in the Calves Clinically Diagnosed with Pneumonitis, Pneumoenteritis and Enteritis

2021 ◽  
Author(s):  
M. Kabu ◽  
C. Uyarlar
Keyword(s):  
Tumor Necrosis Factor ◽  
Total Protein ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Interleukin 1 ◽  
Control Group ◽  
Serum Haptoglobin ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Background: This study aims to determine the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α) in cases of Pneumonia, Pneumoenteritis and Enteritis. Methods: 60 calves were subjected to the study and they were divided into four groups. The study group consisted of the claves diagnosed with clinical pneumonia (Group P; n=15), pneumoenteritis (Group PE; n=15) and enteritis (Group E; n=15) while the control group included the healthy calves (Group C; n=15). The measurements of the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1β), interleukin 6 (IL-6) and tumor necrosis factor-α (TNF-α), Total protein (TP) and Albumin (ALB) were made by using commercial kits. Conclusion: In all infection groups (P, PE ve E), Haptoglobin concentration, serum cytokine (IL-1β, IL-6 and TNF-α) and Albumin values were found to have been higher than the control group (p≤0,005). However, there was no difference in total protein. In the light of these findings, it is suggested that routine controls for Haptoglobin and cytokine (IL-1β, IL-6 and TNF-α) concentrations would be rewarding to determine the severity of the infection, to choose the suitable treatment and to detect subclinical infections in veterinary medicine.

#50 Gestational exposure of tumor necrosis factor-α (TNF-α) inhibitor drugs

2019 ◽  
Vol 88 ◽  
pp. 149-150 ◽  
Author(s):  
Erkoseoglu Ilknur ◽  
Kadioglu Mine ◽  
Cavusoglu Irem ◽  
Sisman Mulkiye ◽  
Aran Turhan ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Gestational Exposure ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Tumor Necrosis Factor-α Production-Enhancing Properties of Novel Adamantylalkylthio Derivatives of Some Heterocyclic Compounds

2005 ◽  
Vol 60 (4) ◽  
pp. 471-475 ◽  
Author(s):  
Barbara Orzeszko ◽  
Tomasz Świtaj ◽  
Anna B. Jakubowska-Mućka ◽  
Witold Lasek ◽  
Andrzej Orzeszko ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Heterocyclic Compounds ◽  
Tumor Necrosis ◽  
The Novel ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Factor Α ◽  
Derivatives Of ◽  
Necrosis Factor

Certain adamantylated heterocycles were previously shown to enhance the secretion of tumor necrosis factor alpha (TNF-α) by murine melanoma cells that have been transduced with the gene for human TNF-α and constitutively expressed this cytokine. The stimulatory potency of those compounds depended, among other factors, on the structure of the linker between the adamantyl residue and the heterocyclic core. In the present study, a series of (1-adamantyl)alkylsulfanyl derivatives of heterocyclic compounds was prepared by alkylation of the corresponding thioheterocyles. Of the novel adamantylalkylthio compounds tested in the aforementioned cell line, 2-(2-adamantan-1-ylethylsulfanyl)- 4-methyl-pyrimidine was found to be the most active

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